The frequency of insertions at repair junctions during alternative end-joining after Scer\SCEI-induced double-strand breaks is significantly decreased relative to wild-type in mus308unspecified mutants.
The spontaneous recessive lethal frequency is lower than for wild-type, but the recessive lethal frequency induced by ethyl nitrosourea is significantly higher than for wild-type in a mus308unspecified background. In these conditions, the frequencies of GC->AT, AT->GC and GC->TA changes are increased, and AT->CG changes are decreased.