Allele Dmel\alc^Ad2

General Information
Symbol	Dmel\alc^Ad2	Species	D. melanogaster
Name		FlyBase ID	FBal0104541
Feature type	allele	Associated gene	Dmel\alc

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Dockendorff et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nonsense point mutation introduces a stop codon at R233 of the RA (long) transcript. This is equivalent to R112 of the RB (short) transcript) (Spasić et al., 2008) Amino acid replacement: R233@. (Spasić et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage (Dockendorff et al., 2000) lethal \| P-stage (with alc^Δ12.125) (Spasić et al., 2008) lethal \| P-stage (with Df(2R)Np5) (Spasić et al., 2008) lethal \| P-stage \| recessive (Spasić et al., 2008) partially lethal - majority die \| larval stage (with alc^Δ12.125) (Spasić et al., 2008) partially lethal - majority die \| larval stage (with Df(2R)Np5) (Spasić et al., 2008) partially lethal - majority die \| larval stage \| recessive (Spasić et al., 2008)
Phenotype Manifest In
	antenna \| adult stage \| somatic clone (Spasić et al., 2008) eye photoreceptor cell \| adult stage \| somatic clone (Spasić et al., 2008) oocyte associated follicular epithelium \| somatic clone (Spasić et al., 2008) optic lobe \| adult stage \| somatic clone (Spasić et al., 2008)
Detailed Description
	Statement Reference The range of stages during which lethality of alc[Ad2] homozygotes, alc[Ad2]/alc[Δ12.125] or alc[Δ12.125]/Df(2R)Np5 occurs is similar, ranging from first instar larvae to pupal stages. Adults with alc[Ad2] homozygous eyes and antennae (inducing homozygous somatic clones in the eye and antenna with Scer\GAL4[ey.PH]; Scer\FLP1[Scer\UAS.cDa] and killing non-mutant cells in the eye with W[GMR.PG]) show progressive neuro-degeneration in the antenna, retina and optic lobes, characterized by the death of neurons and the formation of vacuoles. Retinal development in alc[Ad2] homozygous clones during pupal stages appears to be normal - photoreceptors are specified and patterned correctly and apical-basal polarity of cells in the developing retina is normal. Normal development in these clones is unaffected by starvation of larvae prior to pupation. However, when these clones are made in the follicle epithelia of starved adults, they do cause defects in apical-basal of the epithelium. (Spasić et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	alc^Ad2 is rescued by alc^Scer\UAS.cSa/Scer\GAL4^da.G32 (Spasić et al., 2008) alc^Ad2 is rescued by alc^Scer\UAS.cSa/Scer\GAL4^tub.PU (Spasić et al., 2008)
Comments
Stocks ( 2 )
Bloomington	5510 alc^Ad2/CyO
Kyoto	108268 alc^Ad2/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	alc^Ad2 (Spasić et al., 2008) l(2)45Ad² (Spasić et al., 2008, )
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Spasić et al., 2008, J. Neurosci. 28(25): 6419--6429 Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration. [FBrf0205113] Dockendorff et al., 2000, Mol. Gen. Genet. 263(1): 137--143 Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F₂ lethal screen. [FBrf0126727]

Allele Dmel\alcAd2

Allele Dmel\alc^Ad2