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General Information
Symbol
Dmel\TER9426-8
Species
D. melanogaster
Name
FlyBase ID
FBal0104711
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A9991849C

Amino acid change:

E437A | TER94-PA; E462A | TER94-PC; E395A | TER94-PD; E462A | TER94-PE

Reported amino acid change:

E450A

Comment:

TER9426-8 is reported as a missense mutation that converts amino acid 450, glutamic acid, to alanine (IDAEV to IDAAV in the first ATPase motif. However this sequence of amino acids maps to 434 to 438 in the sequence (GB:AF202034) placing the mutation at amino acid 437.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E437A. This substitution is in the first ATPase motif.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Contrary to expection, TER9426-8 does not suppress polyQ-induced neurodegeneration by inhibiting polyQ aggregation.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

TER9426-8/+ mutant adults do not exhibit significant defects in phototaxis at 20 days of light exposure (dle), nor any defects in geotaxis at 20 or 30 dle, and display normal photoreceptor depolarization following light stimulation, as compared to controls.

Germline clones arrest early in oogenesis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

TER94[+]/TER9426-8 is a non-suppressor of visible phenotype of Hsap\TP53UAS.cYa

TER94[+]/TER9426-8 is a non-suppressor of visible phenotype of rprGMR.PW

TER94[+]/TER9426-8 is a non-suppressor of visible phenotype of hidGMR.PG/WGMR.PG

TER94[+]/TER9426-8 is a non-suppressor of visible phenotype of grimGMR.PC

TER94[+]/TER9426-8 is a non-suppressor of visible phenotype of Cele\ced-4GMR.PK

Phenotype Manifest In
Suppressor of
Statement
Reference

TER94[+]/TER9426-8 is a suppressor | partially of eye phenotype of Scer\GAL4ey.PH, atlUAS.Tag:MYC

TER94[+]/TER9426-8 is a suppressor | partially of retina | adult stage | progressive phenotype of ninaEP37H

TER94[+]/TER9426-8 is a suppressor | partially of retina | adult stage phenotype of ninaED1

TER94[+]/TER9426-8 is a suppressor | partially of eye phenotype of Zzzz\CAGQ92.GMR.Tag:FLAG

NOT Suppressor of
Statement
Reference

TER94[+]/TER9426-8 is a non-suppressor of eye phenotype of Hsap\TP53UAS.cYa

TER94[+]/TER9426-8 is a non-suppressor of eye phenotype of rprGMR.PW

TER94[+]/TER9426-8 is a non-suppressor of eye phenotype of hidGMR.PG/WGMR.PG

TER94[+]/TER9426-8 is a non-suppressor of eye phenotype of grimGMR.PC

TER94[+]/TER9426-8 is a non-suppressor of eye phenotype of Cele\ced-4GMR.PK

Additional Comments
Genetic Interactions
Statement
Reference

The small eye phenotype characteristic for adult flies expressing atlScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF is significantly ameliorated by combination with a single copy of TER9426-8.

TER9426-8/+ partially suppresses the retinal degeneration and photoreceptor neuron loss after 30 days, but not after 20 days, of light exposure; rescues the visual processing defects after 20 days of light exposure; and rescues the photoreceptor depolarization defect seen in flies expressing ninaEP37H.

TER9426-8/+ partially suppresses the retinal degeneration, loss of photoreceptor neurons and fully suppresses the defective phototaxis seen in ninaED1/+ mutant flies.

Expression of ninaE+t2.747 in a TER9426-8/+ background does not result in defects in phototaxis or geotaxis after 20 or 30 days of light exposure, and does not result in a defect in photoreceptor depolarization after 30 or 45 days of light exposure, as compared to controls.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Phenotypic analysis suggests an allelic series, starting from the strongest: TER94k15502, TER9426-8, TER9403775, TER9422-30, TER9414-23, TER9422-26, TER947-12 and TER9443-8.

"ethyl methanesulfonate" was stated as tentative. "diepoxybutane" was stated as tentative. "γ ray" was stated as tentative.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)