FlyBase Allele Report: Scer\GAL4[Ddc.PL]

Scer\GAL4^Ddc.PL drives expression in a subset of the dopaminergic PPL2ab neurons and in the majority of the PAM neurons (includes MB-M3 and MB-MP1 neurons).

(Aso et al., 2012)

Expression observed in neurons that innervate the mushroom body horizontal lobes and the subsesophageal ganglion.

(Yarali and Gerber, 2010)

Expression in the midgut is found in a distinct group of Dh31-expressing enteroendocrine cells located at the junction region of the anterior midgut and the acid-secreting portion of the larval midgut. This junction region occurs at a conspicuous and characteristic U-shaped bend in the gut. These are referred to as the "midgut junction Dh31-expressing cells".

(Lajeunesse et al., 2010)

Expression is seen in dopaminergic and serotonergic neurons and their precursors, totalling 9-11 neurons per abdominal half-neuromere by larval stage L1. A precise pattern can be found in FBrf0160715.

(Landgraf et al., 2003)

Expression is observed in Ddc-expressing neurons.

(Li et al., 2000)

Marker for

dopaminergic neuron

(Joshi et al., 2004, Sykes et al., 2004, Monastirioti, 2003, Yang et al., 2003, Auluck et al., 2002, Feany and Bender, 2000, Li et al., 2000)

serotonergic neuron

(Joshi et al., 2004, Sykes et al., 2004, Monastirioti, 2003, Li et al., 2000)

Reflects expression of

Ddc

(Riemensperger et al., 2013, Aso et al., 2012, Chen et al., 2012, Agrawal et al., 2010, Alekseyenko et al., 2010, Haywood and Staveley, 2004, Joshi et al., 2004, Sykes et al., 2004, Landgraf et al., 2003, Monastirioti, 2003, Yang et al., 2003, Auluck et al., 2002, Haywood et al., 2002, Feany and Bender, 2000, Li et al., 2000)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

behavior defective, with Trh^UAS.cYa

(Yuan et al., 2006)

behavior defective | heat sensitive, with shi^1.UAS

(Alekseyenko et al., 2010, Zhang et al., 2007)

behavior defective | male, with Trh^UAS.cDa

(Dierick and Greenspan, 2007)

body size defective, with Itpr^UAS.cVa, Itpr^sv35/Itpr^ug3

(Agrawal et al., 2009)

chemical resistant, with Hsap\PRKN^WT.UAS

(Wang et al., 2007)

chemical resistant, with Usp30^NIG.3016R

(Bingol et al., 2014)

chemical resistant | female, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

chemical sensitive | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

chemical sensitive | adult stage, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

chemical sensitive | adult stage, with Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

chemical sensitive | male, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

courtship behavior defective | :chemical conditional | heat sensitive, with shi^1.UAS

(Lee et al., 2008)

courtship behavior defective | female, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Kadener et al., 2006)

decreased cell death, with BacA\p35^UAS.cHa

(Sykes et al., 2004)

decreased cell number | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2017)

decreased cell number | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

decreased cell number | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

decreased cell number | adult stage, with srl^KK100201

(Ng et al., 2017)

decreased cell number | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

decreased cell number | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

developmental rate defective, with Ns3^GD8441

(Kaplan et al., 2008)

developmental rate defective, with Ns3^{K350N.UAS.Venus}

(Hartl et al., 2013)

flight defective, with Ctet\tetX^{TNT-LC.UAS.cKa}

(Banerjee et al., 2004)

flight defective, with elgi^UAS.Tag:HA

(Tan et al., 2011)

flightless | partially, with Gαq^{dsRNA.UAS.1f1}

(Banerjee et al., 2006)

grooming behavior defective, with Vmat^{UAS.Ex.Tag:HA}

(Chang et al., 2006)

hypoactive, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

increased cell number | adult stage, with Hsap\SNCA^A53T.UAS.cKa

(Butler et al., 2012)

increased cell size | third instar larval stage, with Hsap\SNCAIP^UAS.cLa

(Liu et al., 2012)

lethal, with EndoB^GD14693

(Zhu et al., 2013)

lethal, with sgg^UAS.cBa

(Trostnikov et al., 2019)

lethal - all die during pupal stage, with spg^{dsRNA.1447-1632.UAS}

(Eguchi et al., 2013)

locomotor behavior defective, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Liu et al., 2008)

locomotor behavior defective, with Hsap\LRRK2^UAS.Tag:FLAG

(Liu et al., 2008)

locomotor behavior defective, with Uch^GD11265

(Tran et al., 2018)

locomotor behavior defective | adult stage, with Buffy^dsRNA.UAS

(M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage, with Buffy^UAS.cQa

(M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage, with DJ-1α^dsRNA.UAS

(Faust et al., 2009)

locomotor behavior defective | adult stage, with Hsap\GBA^{84GG.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

locomotor behavior defective | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Liu et al., 2011)

locomotor behavior defective | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2017, Ng et al., 2012)

locomotor behavior defective | adult stage, with Hsap\SNCA^A30P.UAS

(Riemensperger et al., 2013)

locomotor behavior defective | adult stage, with Hsap\SNCA^A53T.UAS.cKa

(Karpinar et al., 2009)

locomotor behavior defective | adult stage, with Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016, M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage, with Lfg^HMS00225

(M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage, with Lfg^KK104535

(M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage, with MICU1^GD4927

(M'Angale and Staveley, 2017)

locomotor behavior defective | adult stage, with park^dsRNA.UAS

(M'Angale and Staveley, 2017)

locomotor behavior defective | adult stage, with Pink1^dsRNA.UAS

(M'Angale and Staveley, 2017)

locomotor behavior defective | adult stage, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

locomotor behavior defective | adult stage, with Vmat^{UAS.Ex.Tag:HA}

(Chang et al., 2006)

locomotor behavior defective | adult stage | conditional, with Hsap\SNCA^A53T.UAS.cKa

(Butler et al., 2012)

locomotor behavior defective | adult stage | progressive, with Atg6^GD11647

(M'Angale and Staveley, 2016)

locomotor behavior defective | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2013)

locomotor behavior defective | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2013)

locomotor behavior defective | adult stage | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

locomotor behavior defective | adult stage | progressive, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

locomotor behavior defective | adult stage | progressive, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

locomotor behavior defective | adult stage | progressive, with Hsap\LRRK2^{Y1699C.UAS.Tag:MYC}

(Ng et al., 2009)

locomotor behavior defective | adult stage | progressive, with Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

locomotor behavior defective | adult stage | progressive, with Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016, Todd and Staveley, 2008)

locomotor behavior defective | adult stage | progressive, with Pi3K59F^KK107602

(M'Angale and Staveley, 2016)

locomotor behavior defective | chemical conditional, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Yang et al., 2012)

locomotor behavior defective | chemical conditional, with Hsap\LRRK2^UAS.Tag:FLAG

(Yang et al., 2012)

locomotor behavior defective | heat sensitive, with Hsap\TOR1A^ΔE.UAS

(Koh et al., 2004)

locomotor behavior defective | progressive, with Debcl^UAS.Tag:HA

(M'Angale and Staveley, 2016)

locomotor behavior defective | progressive, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

locomotor behavior defective | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Martin et al., 2014)

locomotor behavior defective | third instar larval stage, with Ctet\tetX^TNT-LC.UAS

(Suster et al., 2003)

locomotor rhythm defective, with Hsap\SNCA^A53T.UAS.cKa

(Gajula Balija et al., 2011)

locomotor rhythm defective, with Hsap\SNCA^TP.UAS.cKa

(Gajula Balija et al., 2011)

locomotor rhythm defective, with Hsap\SNCA^UAS.cKa

(Gajula Balija et al., 2011)

locomotor rhythm defective, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

long lived, with Buffy^UAS.cQa

(M'Angale and Staveley, 2016)

long lived, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

long lived | chemical conditional, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

majority die during pupal stage, with Hsc70-5^KK100233

(Zhu et al., 2013)

memory defective, with Ctet\tetX^TNT-LC.UAS

(Sitaraman et al., 2008)

memory defective, with Ctet\tetX^TNT-LC.UAS, Scer\GAL4^ple.PF

(Sitaraman et al., 2008)

memory defective, with per^{dsRNA.PAS.UAS}

(Chen et al., 2012)

memory defective, with Rcom\RT^A-cs2.UAS

(Chen et al., 2012)

memory defective, with w^{dsRNA.UAS.cKa}

(Sitaraman et al., 2008)

memory defective | adult stage | :heat sensitive | conditional, with shi^1.UAS

(Vogt et al., 2014)

memory defective | adult stage | :heat sensitive | nutrition conditional, with TrpA1^UAS.(B).cKa

(Liu et al., 2012)

memory defective | adult stage | conditional, with Ctet\tetX^TNT-LC.UAS

(Sitaraman et al., 2017)

memory defective | adult stage | heat sensitive, with Scer\GAL80^ple.PK, TrpA1^UAS.(B).cKa

(Liu et al., 2012)

memory defective | adult stage | heat sensitive, with shi^1.UAS

(Liu et al., 2012)

memory defective | adult stage | heat sensitive, with shi^{ts1.IVS.p10.20xUAS}

(Shyu et al., 2017)

memory defective | adult stage | heat sensitive, with TrpA1^UAS.(B).cKa

(Shyu et al., 2017)

memory defective | heat sensitive, with TrpA1^UAS.(B).cKa

(Aso et al., 2012)

neuroanatomy defective, with Hsap\GPR37^UAS.cYa

(Yang et al., 2003)

neuroanatomy defective, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

neuroanatomy defective, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Liu et al., 2011)

neuroanatomy defective, with Hsap\SNCA^A30P.UAS

(Yang et al., 2003, Auluck et al., 2002)

neuroanatomy defective, with Hsap\SNCA^A53T.UAS

(Yang et al., 2003, Auluck et al., 2002)

neuroanatomy defective, with Hsap\SNCA^UAS.cFa

(Yang et al., 2003, Auluck et al., 2002)

neuroanatomy defective, with Hsc70-4^K71S.UAS

(Auluck et al., 2002)

neuroanatomy defective, with Pink1^{dsRNA.UAS.cWa}

(Wang et al., 2006)

neuroanatomy defective | adult stage, with elgi^UAS.Tag:HA

(Tan et al., 2011)

neuroanatomy defective | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

neuroanatomy defective | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

neuroanatomy defective | adult stage, with Hsap\SNCA^A53T.UAS.cKa

(Butler et al., 2012)

neuroanatomy defective | adult stage, with Septin4^UAS.cMa

(Muñoz-Soriano and Paricio, 2007)

neuroanatomy defective | adult stage | progressive, with DJ-1α^dsRNA.UAS

(Faust et al., 2009)

neuroanatomy defective | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

neuroanatomy defective | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

neuroanatomy defective | adult stage | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

neuroanatomy defective | adult stage | progressive, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

neuroanatomy defective | adult stage | progressive, with Hsap\LRRK2^{Y1699C.UAS.Tag:MYC}

(Ng et al., 2009)

neuroanatomy defective | adult stage | progressive, with Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

neuroanatomy defective | chemical conditional, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Yang et al., 2012)

neuroanatomy defective | chemical conditional, with Hsap\LRRK2^UAS.Tag:FLAG

(Yang et al., 2012)

neuroanatomy defective | progressive, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Martin et al., 2014)

neuroanatomy defective | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Martin et al., 2014)

neurophysiology defective, with Ctet\tetX^{TNT-LC.UAS.cKa}

(Banerjee et al., 2004)

neurophysiology defective, with Itpr^NIG.1063R

(Agrawal et al., 2010)

oxidative stress response defective | chemical conditional, with Usp30^NIG.3016R

(Bingol et al., 2014)

partially lethal - majority live, with Mmus\Prnp^P101L.UAS

(Gavin et al., 2006)

phototaxis defective, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

phototaxis defective, with Scer\GAL4^ple.PF, ple², ple^UAS.cFa

(Riemensperger et al., 2011)

short lived

(Haywood et al., 2002)

short lived, with Atg6^GD11647

(M'Angale and Staveley, 2016)

short lived, with Buffy^dsRNA.UAS

(M'Angale and Staveley, 2016)

short lived, with Debcl^UAS.Tag:HA

(M'Angale and Staveley, 2016)

short lived, with Hsap\GBA^{84GG.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

short lived, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

short lived, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

short lived, with Hsap\LRRK2^{G2019S.UAS.cMa}

(Macleod et al., 2013)

short lived, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Liu et al., 2011, Liu et al., 2008)

short lived, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

short lived, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

short lived, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

short lived, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

short lived, with Hsap\LRRK2^UAS.Tag:FLAG

(Liu et al., 2008)

short lived, with Hsap\LRRK2^{Y1699C.UAS.Tag:MYC}

(Ng et al., 2009)

short lived, with Hsap\SNCA^A53T.UAS.cKa

(Butler et al., 2012, Karpinar et al., 2009)

short lived, with Hsap\SNCA^A56P.UAS.cKa

(Karpinar et al., 2009)

short lived, with Hsap\SNCA^TP.UAS.cKa

(Karpinar et al., 2009)

short lived, with Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016, M'Angale and Staveley, 2016, M'Angale and Staveley, 2016)

short lived, with Lfg^HMS00225

(M'Angale and Staveley, 2016)

short lived, with Lfg^KK104535

(M'Angale and Staveley, 2016)

short lived, with MICU1^GD4927

(M'Angale and Staveley, 2017)

short lived, with Mmus\Prnp^P101L.UAS

(Gavin et al., 2006)

short lived, with park^dsRNA.UAS

(M'Angale and Staveley, 2017)

short lived, with Pi3K59F^KK107602

(M'Angale and Staveley, 2016)

short lived, with Pink1^dsRNA.UAS

(M'Angale and Staveley, 2017)

short lived | chemical conditional, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Yang et al., 2012)

short lived | chemical conditional, with Hsap\LRRK2^UAS.Tag:FLAG

(Yang et al., 2012)

short lived | progressive, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

sleep defective, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

small body, with Ns3^GD8441

(Kaplan et al., 2008)

smell perception defective, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

smell perception defective | heat sensitive, with shi^1.UAS

(Kaun et al., 2011)

some die during larval stage, with Mmus\Prnp^P101L.UAS

(Gavin et al., 2006)

song defective, with Vmat^{UAS.Ex.Tag:HA}

(Chang et al., 2006)

starvation stress response defective | adult stage, with Hsap\SNCAIP^UAS.cLa

(Liu et al., 2012)

starvation stress response defective | female limited, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

stress response defective, with Mrp4^EP3177

(Huang and Haddad, 2007)

stress response defective, with Same\Laz^UAS.cRa

(Ruiz et al., 2012)

thermotaxis defective | adult stage | conditional, with Ctet\tetX^TNT-LC.UAS

(Sitaraman et al., 2017)

uncoordinated | adult stage, with Mmus\Prnp^P101L.UAS

(Gavin et al., 2006)

viable, with COX5B^GD6659

(Kemppainen et al., 2014)

viable, with COX6B^GD13061

(Kemppainen et al., 2014)

viable, with fh^{dsRNA.UAS.cLa}

(Llorens et al., 2007)

viable, with fh^UAS.cLa

(Llorens et al., 2007)

visual behavior defective, with Scer\GAL4^ple.PF, ple², ple^FS.UAS

(Riemensperger et al., 2011)

visual behavior defective, with Scer\GAL4^ple.PF, ple², ple^UAS.cFa

(Riemensperger et al., 2011)

visual behavior defective | heat sensitive, with shi^1.UAS

(Andretic et al., 2005)

Phenotype Manifest In

axon | progressive, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

dendrite, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

dopamine neuron & adult brain, with Pink1^{dsRNA.UAS.cWa}

(Wang et al., 2006)

dopaminergic neuron, with DJ-1α^dsRNA.UAS

(Yang et al., 2005)

dopaminergic neuron, with Hsap\GPR37^UAS.cYa

(Yang et al., 2003)

dopaminergic neuron, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

dopaminergic neuron, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Liu et al., 2011, Liu et al., 2008)

dopaminergic neuron, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2012)

dopaminergic neuron, with Hsap\LRRK2^UAS.Tag:FLAG

(Liu et al., 2008)

dopaminergic neuron, with Hsap\SNCA^A30P.UAS

(Yang et al., 2003, Auluck et al., 2002)

dopaminergic neuron, with Hsap\SNCA^A53T.UAS

(Yang et al., 2003, Auluck et al., 2002)

dopaminergic neuron, with Hsap\SNCA^UAS.cFa

(Lee et al., 2009, Yang et al., 2003, Auluck et al., 2002)

dopaminergic neuron, with Hsc70-4^K71S.UAS

(Auluck et al., 2002)

dopaminergic neuron & adult brain, with Septin4^UAS.cMa

(Muñoz-Soriano and Paricio, 2007)

dopaminergic neuron | adult stage, with elgi^UAS.Tag:HA

(Tan et al., 2011)

dopaminergic neuron | adult stage, with Hsap\SNCA^A53T.UAS.cKa

(Butler et al., 2012)

dopaminergic neuron | adult stage | progressive, with DJ-1α^dsRNA.UAS

(Faust et al., 2009)

dopaminergic neuron | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic neuron | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic neuron | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Martin et al., 2014)

dopaminergic neuron | supernumerary, with BacA\p35^UAS.cHa

(Sykes et al., 2004)

dopaminergic PAL neuron | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PAL neuron | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PAL neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PAM neuron | adult stage, with Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

dopaminergic PPL1 neuron, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2012)

dopaminergic PPL1 neuron | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2017)

dopaminergic PPL1 neuron | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPL1 neuron | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPL1 neuron | adult stage, with srl^KK100201

(Ng et al., 2017)

dopaminergic PPL1 neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPL1 neuron | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPL1 neuron | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPL1 neuron | adult stage | progressive, with Hsap\PRKN^R275W.UAS

(Wang et al., 2007)

dopaminergic PPL2ab neuron | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPL2ab neuron | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPM1 neuron | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPM1 neuron | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPM1 neuron | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM1 neuron | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM1 neuron | adult stage | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM1 neuron | adult stage | progressive, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM1 neuron | adult stage | progressive, with Hsap\LRRK2^{Y1699C.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM2 neuron | adult stage, with Hsap\LRRK2^{R1441C.UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPM2 neuron | adult stage, with Hsap\LRRK2^{UAS.cIa.Tag:FLAG}

(Islam et al., 2016)

dopaminergic PPM2 neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM2 neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM2 neuron | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM2 neuron | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM3 neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM3 neuron | adult stage | chemical conditional, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM3 neuron | adult stage | progressive, with Hsap\GBA^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM3 neuron | adult stage | progressive, with Hsap\GBA^{N370S.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2016)

dopaminergic PPM3 neuron | adult stage | progressive, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM3 neuron | adult stage | progressive, with Hsap\LRRK2^{G2385R.UAS.Tag:MYC}

(Ng et al., 2009)

dopaminergic PPM3 neuron | adult stage | progressive, with Hsap\LRRK2^{Y1699C.UAS.Tag:MYC}

(Ng et al., 2009)

dorso-lateral dopaminergic neuron, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

dorso-lateral dopaminergic neuron, with Hsap\SNCA^A30P.UAS

(Auluck et al., 2002)

dorso-lateral dopaminergic neuron, with Hsap\SNCA^A53T.UAS

(Auluck et al., 2002)

dorso-lateral dopaminergic neuron, with Hsap\SNCA^UAS.cFa

(Auluck et al., 2002)

embryonic/larval fat body | third instar larval stage, with Hsap\SNCAIP^UAS.cLa

(Liu et al., 2012)

flight muscle | adult stage, with srl^KK100201

(Ng et al., 2017)

indirect flight muscle, with Ctet\tetX^{TNT-LC.UAS.cKa}

(Banerjee et al., 2004)

lipid droplet, with Hsap\SNCAIP^UAS.cLa

(Liu et al., 2012)

mitochondrion, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2012)

mitochondrion | adult stage, with Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2017)

mitochondrion | adult stage, with srl^KK100201

(Ng et al., 2017)

neuron | progressive, with Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}

(Lin et al., 2010)

wing, with Gαq^UAS.cRa

(Banerjee et al., 2006)

Detailed Description

Statement

Reference

Inhibition (using shi^{ts1.IVS.p10.20xUAS} at 32[o]C) of Scer\GAL4^Ddc.PL cells in adults significantly reduces 3-min associative olfactory water-reward memory, compared to controls; inhibition during acquisition alone also significantly reduces 3-hour and 24-hour memory.

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 31[o]C) of Scer\GAL4^Ddc.PL cells in thirsty or water-sated adults, in combination with a paired odor, results in a significant increase in 3-min, 3-hour and 24-hour associative attractive olfactory memory, compared to controls.

(Shyu et al., 2017)

Inhibition (using Ctet\tetX^TNT.UAS) of a subset of Scer\GAL4^Ddc.PL cells (expression restricted using Scer\GAL80^ple.PK) does not affect latency of escape from heat or associative aversive (heat) place memory, compared to controls; the increases in escape latency and aversive memory due to unexpected high (41[o]C) temperature pre-exposure are significantly lower than those of controls.

(Sitaraman et al., 2017)

Inhibition (using Hsap\KCNJ2^UAS.EGFP) of Scer\GAL4^Ddc.PL cells, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, does not affect aversive temperature or shock olfactory memory, compared to controls, and there is no effect on temperature avoidance.

(Galili et al., 2014)

Inhibition (using shi^1.UAS at 33[o]C) of Scer\GAL4^Ddc.PL cells in adults significantly reduces appetitive, but not aversive, 1-min visual memory, compared to controls; inhibition during training alone, but not testing, significantly reduces appetitive, but not aversive, 30-min visual memory, compared to controls; inhibition does not significantly affect sugar preference, compared to controls.

(Vogt et al., 2014)

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 30[o]C) of Scer\GAL4^Ddc.PL cells in starved, but not fed, adults, in combination with a paired odor, results in a significant increase in 2-min associative attractive olfactory memory, compared to controls; this memory increase is still seen when activation is restricted to a smaller number of Scer\GAL4^Ddc.PL cells using Scer\GAL80^ple.PK, but not Scer\GAL80^R58E02; a significant increase in 12-hour memory also occurs when flies are starved or fed prior to training, but not if they are fed immediately before testing.

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^Ddc.PL cells in adults fed immediately before training does not significantly affect 3-hour associative appetitive olfactory memory, compared to controls; inhibition before and during training, but not after training and during testing, significantly reduces 30-min associative appetitive olfactory memory, compared to controls; inhibition also significantly reduces short-term associative appetitive olfactory memory, compared to controls, but not when restricted to a smaller subset of Scer\GAL4^Ddc.PL cells using Scer\GAL80^R58E02; inhibition has no effect on naive sugar preference, compared to controls.

(Liu et al., 2012)

Animals expressing two copies of Scer\GAL4^Ddc.PL exhibit a greatly reduced lifespan, compared to wild-type. their locomotion remains normal.

(Haywood et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Ddc.PL, park^dsRNA.UAS has short lived phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Scer\GAL4^Ddc.PL, park^dsRNA.UAS has locomotor behavior defective | adult stage phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, enhanceable by Buffy^dsRNA.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Buffy^dsRNA.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Atg6^GD11647, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Atg6^GD11647, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage | progressive phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, enhanceable by AMPKα^GD736, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Scer\GAL4^Ddc.PL, Septin4^UAS.cMa has neuroanatomy defective | adult stage phenotype, enhanceable by park^Δ21/park[+]

(Muñoz-Soriano and Paricio, 2007)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has increased cell death phenotype, enhanceable by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, enhanceable by park^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage | progressive phenotype, non-enhanceable by Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage | progressive phenotype, non-enhanceable by Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, non-enhanceable by sgg^UAS.cBa, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Suppressed by

Statement

Reference

MICU1^GD4927, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

MICU1^GD4927, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Pink1^dsRNA.UAS, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Pink1^dsRNA.UAS, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has decreased cell number | adult stage phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible | partially by srl^UAS.cTa, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has decreased cell number | adult stage phenotype, suppressible by srl^UAS.cTa, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Lfg^KK104535, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Lfg^KK104535, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Lfg^HMS00225, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Lfg^HMS00225, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Pi3K59F^KK107602, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Pi3K59F^KK107602, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage | progressive phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL has locomotor behavior defective | progressive phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Debcl^JF02429, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Debcl^JF02429, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Scer\GAL4^Ddc.PL, Usp30^NIG.3016R has oxidative stress response defective | chemical conditional phenotype, suppressible by Hsap\USP30^UAS.cBa, Scer\GAL4^Ddc.PL

(Bingol et al., 2014)

Scer\GAL4^Ddc.PL, Usp30^NIG.3016R has chemical resistant phenotype, suppressible by Hsap\USP30^UAS.cBa, Scer\GAL4^Ddc.PL

(Bingol et al., 2014)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective | progressive phenotype, suppressible by Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has locomotor behavior defective | progressive phenotype, suppressible by Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective | progressive phenotype, suppressible by Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL has neuroanatomy defective | adult stage phenotype, suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL has gravitaxis defective | adult stage | conditional phenotype, suppressible | partially by Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL has increased cell number | adult stage phenotype, suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL has neuroanatomy defective | adult stage phenotype, suppressible | partially by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL has flight defective phenotype, suppressible | partially by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by sgg^A81T.UAS, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has locomotor behavior defective | progressive phenotype, suppressible by sgg^A81T.UAS, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has short lived | progressive phenotype, suppressible by sgg^A81T.UAS, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has neuroanatomy defective | adult stage | progressive phenotype, suppressible by Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, suppressible by Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage | progressive phenotype, suppressible by Pink1^UAS.cTa, Scer\GAL4^Ddc.PL

(Todd and Staveley, 2008)

Scer\GAL4^Ddc.PL, Septin4^UAS.cMa has neuroanatomy defective | adult stage phenotype, suppressible | partially by park^UAS.cMa/Scer\GAL4^Ddc.PL

(Muñoz-Soriano and Paricio, 2007)

Pink1^{dsRNA.UAS.cWa}, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\PINK1^UAS.Tag:FLAG, Scer\GAL4^Ddc.PL

(Wang et al., 2006)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has increased cell death phenotype, suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^Ddc.PL, srl^KK100201 has decreased cell number | adult stage phenotype, non-suppressible by AMPKα^TD.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has locomotor behavior defective | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has decreased cell number | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective | progressive phenotype, non-suppressible by Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has locomotor behavior defective | progressive phenotype, non-suppressible by Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL has short lived phenotype, non-suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has neuroanatomy defective phenotype, non-suppressible by sgg^UAS.cBa, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Enhancer of

Statement

Reference

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Scer\GAL4^Ddc.PL, park^dsRNA.UAS

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage phenotype of Scer\GAL4^Ddc.PL, park^dsRNA.UAS

(M'Angale and Staveley, 2017)

Buffy^dsRNA.UAS/Scer\GAL4^Ddc.PL is an enhancer of visible phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^dsRNA.UAS, Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^dsRNA.UAS, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage | progressive phenotype of Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Pi3K59F^KK107602, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Atg6^GD11647, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL is an enhancer of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

AMPKα^GD736, Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL is an enhancer of locomotor behavior defective | adult stage phenotype of park¹

(Wang et al., 2007)

Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL is an enhancer of increased cell death phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

park^dsRNA.UAS, Scer\GAL4^Ddc.PL is an enhancer of neuroanatomy defective phenotype of Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL is an enhancer of neuroanatomy defective phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhancer of

Statement

Reference

Pi3K59F^KK107602, Scer\GAL4^Ddc.PL is a non-enhancer of locomotor behavior defective | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Atg6^GD11647, Scer\GAL4^Ddc.PL is a non-enhancer of locomotor behavior defective | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

sgg^UAS.cBa, Scer\GAL4^Ddc.PL is a non-enhancer of neuroanatomy defective phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Suppressor of

Statement

Reference

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor | partially of visible | adult stage phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor | partially of visible | adult stage phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+], NUCB1^NIG.32190R, Orai^k11505, Scer\GAL4^Ddc.PL is a suppressor | partially of flight defective phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+], NUCB1^NIG.32190R, Orai^k11505, Scer\GAL4^Ddc.PL is a suppressor | partially of flight defective phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of MICU1^GD4927, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of locomotor behavior defective | adult stage phenotype of MICU1^GD4927, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of Pink1^dsRNA.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Pink1^dsRNA.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

AMPKα^TD.UAS, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

AMPKα^TD.UAS, Scer\GAL4^Ddc.PL is a suppressor of decreased cell number | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

srl^UAS.cTa, Scer\GAL4^Ddc.PL is a suppressor | partially of locomotor behavior defective | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

srl^UAS.cTa, Scer\GAL4^Ddc.PL is a suppressor of decreased cell number | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Lfg^KK104535, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Lfg^KK104535, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Lfg^KK104535, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Lfg^HMS00225, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Lfg^HMS00225, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Lfg^HMS00225, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage | progressive phenotype of Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of short lived phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa, Scer\GAL4^Ddc.PL is a suppressor | partially of locomotor behavior defective | progressive phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^JF02429, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^JF02429, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\USP30^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor of oxidative stress response defective | chemical conditional phenotype of Scer\GAL4^Ddc.PL, Usp30^NIG.3016R

(Bingol et al., 2014)

Hsap\USP30^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor of chemical resistant phenotype of Scer\GAL4^Ddc.PL, Usp30^NIG.3016R

(Bingol et al., 2014)

Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective | adult stage phenotype of Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor | partially of gravitaxis defective | adult stage | conditional phenotype of Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor of increased cell number | adult stage phenotype of Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor | partially of neuroanatomy defective | adult stage phenotype of elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor | partially of flight defective phenotype of elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

Stim^UAS.cAa/Scer\GAL4^Ddc.PL is a suppressor of visible phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ddc.PL is a suppressor of neurophysiology defective phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ddc.PL is a suppressor of flight defective phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

sgg^A81T.UAS, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

sgg^A81T.UAS, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

sgg^A81T.UAS, Scer\GAL4^Ddc.PL is a suppressor of short lived | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective | adult stage | progressive phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Pink1^UAS.cTa, Scer\GAL4^Ddc.PL is a suppressor of locomotor behavior defective | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Todd and Staveley, 2008)

park^UAS.cMa/Scer\GAL4^Ddc.PL is a suppressor | partially of neuroanatomy defective | adult stage phenotype of Scer\GAL4^Ddc.PL, Septin4^UAS.cMa

(Muñoz-Soriano and Paricio, 2007)

Gαq^UAS.cRa/Scer\GAL4^Ddc.PL is a suppressor | partially of flightless | partially phenotype of Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361

(Banerjee et al., 2006)

Gαq^UAS.cRa/Scer\GAL4^Ddc.PL is a suppressor | partially of neurophysiology defective phenotype of Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361

(Banerjee et al., 2006)

Hsap\PINK1^UAS.Tag:FLAG, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Pink1^{dsRNA.UAS.cWa}, Scer\GAL4^Ddc.PL

(Wang et al., 2006)

bsk^K53R.UAS/Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of hep¹

(Cha et al., 2005)

Pi3K92E^UAS.Tag:MYC, Scer\GAL4^Ddc.PL is a suppressor of increased cell death phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Suppressor of

Statement

Reference

SERCA[+], NUCB1^NIG.32190R, Scer\GAL4^Ddc.PL, SERCA^Kum170 is a non-suppressor of flight defective phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^NIG.32190R, Scer\GAL4^Ddc.PL, SERCA^Kum170 is a non-suppressor of flight defective phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

AMPKα^TD.UAS, Scer\GAL4^Ddc.PL is a non-suppressor of decreased cell number | adult stage phenotype of Scer\GAL4^Ddc.PL, srl^KK100201

(Ng et al., 2017)

AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL is a non-suppressor of locomotor behavior defective | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL is a non-suppressor of neuroanatomy defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL is a non-suppressor of locomotor behavior defective | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Scer\LSG1^UAS.cHa/Scer\GAL4^Ddc.PL is a non-suppressor of developmental rate defective | male phenotype of Ns3^G0431

(Hartl et al., 2013)

Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL is a non-suppressor of short lived phenotype of Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

sgg^UAS.cBa, Scer\GAL4^Ddc.PL is a non-suppressor of neuroanatomy defective phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Ddc.PL, Septin4^UAS.cMa has dopaminergic neuron & adult brain phenotype, enhanceable by park^Δ21/park[+]

(Muñoz-Soriano and Paricio, 2007)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, enhanceable by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, enhanceable by park^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPL1 neuron phenotype, non-enhanceable by AMPKα^GD736, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has dendrite phenotype, non-enhanceable by sgg^UAS.cBa, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Suppressed by

Statement

Reference

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPL1 neuron | adult stage phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has mitochondrion | adult stage phenotype, suppressible by srl^UAS.cTa, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPL1 neuron | adult stage phenotype, suppressible by srl^UAS.cTa, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has dopaminergic neuron | progressive phenotype, suppressible by Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL has dopaminergic neuron | adult stage phenotype, suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has mitochondrion phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL has dopaminergic neuron | adult stage phenotype, suppressible | partially by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has dendrite phenotype, suppressible by sgg^A81T.UAS, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron | adult stage | progressive phenotype, suppressible by Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\UBC^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(Lee et al., 2009)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPM2 neuron | adult stage | chemical conditional phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPM3 neuron | adult stage | chemical conditional phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPM1 neuron | adult stage | progressive phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPM3 neuron | adult stage | progressive phenotype, suppressible by Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Scer\GAL4^Ddc.PL, Septin4^UAS.cMa has dopaminergic neuron & adult brain phenotype, suppressible | partially by park^UAS.cMa/Scer\GAL4^Ddc.PL

(Muñoz-Soriano and Paricio, 2007)

Pink1^{dsRNA.UAS.cWa}, Scer\GAL4^Ddc.PL has dopamine neuron & adult brain phenotype, suppressible by Hsap\PINK1^UAS.Tag:FLAG, Scer\GAL4^Ddc.PL

(Wang et al., 2006)

DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^Ddc.PL, srl^KK100201 has dopaminergic PPL1 neuron | adult stage phenotype, non-suppressible by AMPKα^TD.UAS, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL has dopaminergic PPL1 neuron | adult stage phenotype, non-suppressible by AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL has dopaminergic neuron | progressive phenotype, non-suppressible by Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL has dendrite phenotype, non-suppressible by sgg^UAS.cBa, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Enhancer of

Statement

Reference

Buffy^dsRNA.UAS/Scer\GAL4^Ddc.PL is an enhancer of eye phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL is an enhancer of dopaminergic neuron phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

park^dsRNA.UAS, Scer\GAL4^Ddc.PL is an enhancer of dopaminergic neuron phenotype of Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL is an enhancer of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhancer of

Statement

Reference

AMPKα^GD736, Scer\GAL4^Ddc.PL is a non-enhancer of dopaminergic PPL1 neuron phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

sgg^UAS.cBa, Scer\GAL4^Ddc.PL is a non-enhancer of dendrite phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL is a non-enhancer of dopaminergic PPL1 neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL is a non-enhancer of dopaminergic PAM neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Suppressor of

Statement

Reference

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor | partially of wing phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor | partially of wing phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

AMPKα^TD.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

srl^UAS.cTa, Scer\GAL4^Ddc.PL is a suppressor of mitochondrion | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

srl^UAS.cTa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Lfg^KK104535, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Buffy^UAS.cQa/Scer\GAL4^Ddc.PL is a suppressor of eye phenotype of Lfg^HMS00225, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\RPS15^T136A.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

Hsap\TRAP1^UAS.cBa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron | adult stage phenotype of Hsap\SNCA^A53T.UAS.cKa, Scer\GAL4^Ddc.PL

(Butler et al., 2012)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of mitochondrion phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2012)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor | partially of dopaminergic neuron | adult stage phenotype of elgi^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(Tan et al., 2011)

Stim^UAS.cAa/Scer\GAL4^Ddc.PL is a suppressor of wing phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

sgg^A81T.UAS, Scer\GAL4^Ddc.PL is a suppressor of dendrite phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron | adult stage | progressive phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\UBC^UAS.Tag:HA, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Lee et al., 2009)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPM2 neuron | adult stage | chemical conditional phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPM3 neuron | adult stage | chemical conditional phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPM1 neuron | adult stage | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

Hsap\PRKN^WT.UAS, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPM3 neuron | adult stage | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2009)

park^UAS.cMa/Scer\GAL4^Ddc.PL is a suppressor | partially of dopaminergic neuron & adult brain phenotype of Scer\GAL4^Ddc.PL, Septin4^UAS.cMa

(Muñoz-Soriano and Paricio, 2007)

Hsap\PRKN^WT.UAS/Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Hsap\PRKN^WT.UAS/Scer\GAL4^Ddc.PL is a suppressor of dopaminergic PAM neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Gαq^UAS.cRa/Scer\GAL4^Ddc.PL is a suppressor | partially of wing phenotype of Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361

(Banerjee et al., 2006)

Hsap\PINK1^UAS.Tag:FLAG, Scer\GAL4^Ddc.PL is a suppressor of dopamine neuron & adult brain phenotype of Pink1^{dsRNA.UAS.cWa}, Scer\GAL4^Ddc.PL

(Wang et al., 2006)

bsk^K53R.UAS/Scer\GAL4^Ddc.PL is a suppressor of insulin secreting cell of pars intercerebralis phenotype of hep¹

(Cha et al., 2005)

Pi3K92E^UAS.Tag:MYC, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of DJ-1α^dsRNA.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2005)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^A53T.UAS, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\GPR37^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Suppressor of

Statement

Reference

AMPKα^TD.UAS, Scer\GAL4^Ddc.PL is a non-suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Scer\GAL4^Ddc.PL, srl^KK100201

(Ng et al., 2017)

AMPKα^TD.UAS/srl^KK100201, Scer\GAL4^Ddc.PL is a non-suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PL

(Ng et al., 2017)

Hsap\RPS15^UAS.cMa, Scer\GAL4^Ddc.PL is a non-suppressor of dopaminergic neuron | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Martin et al., 2014)

sgg^UAS.cBa, Scer\GAL4^Ddc.PL is a non-suppressor of dendrite phenotype of Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^Ddc.PL

(Lin et al., 2010)

Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL is a non-suppressor of dopaminergic PPL1 neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Hsap\PRKN^R275W.UAS/Scer\GAL4^Ddc.PL is a non-suppressor of dopaminergic PAM neuron | adult stage phenotype of park¹

(Wang et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

hig^UAS.GFP/Scer\GAL4^Ddc.PL rescues hig^dd37

(Nakayama et al., 2014)

Scer\GAL4^ple.PF, Scer\GAL4^ple.PF, ple^UAS.cFa, Scer\GAL4^Ddc.PL rescues ple²

(Riemensperger et al., 2011)

Scer\GAL4^ple.PF, Scer\GAL4^ple.PF, ple^FS.UAS, Scer\GAL4^Ddc.PL rescues ple²

(Riemensperger et al., 2011)

park^UAS.Tag:MYC/Scer\GAL4^Ddc.PL rescues park¹

(Cha et al., 2005)

Scer\GAL4^Ddc.PL/Itpr^UAS.cVa rescues Itpr^wc703/Itpr^ug3

(Banerjee et al., 2004)

Scer\GAL4^Ddc.PL/Itpr^UAS.cVa rescues Itpr^ug3/Itpr^ka1091

(Banerjee et al., 2004)

Partially rescues

Scer\GAL4^Ddc.PL/Ns3^UAS.Venus partially rescues Ns3^G0431

(Hartl et al., 2013)

Scer\GAL4^Ddc.PL/Ns3^UAS.Venus partially rescues Ns3^{K350N.UAS.Venus}

(Hartl et al., 2013)

Itpr^ug3, Scer\GAL4^Ddc.PL, Itpr^UAS.cVa partially rescues Itpr^sv35

(Agrawal et al., 2009)

Scer\GAL4^Ilp2.PR, Itpr^ug3, Scer\GAL4^Ddc.PL, Itpr^UAS.cVa partially rescues Itpr^sv35

(Agrawal et al., 2009)

fbl^L.UAS/Scer\GAL4^Ddc.PL partially rescues fbl¹

(Wu et al., 2009)

Ns3^UAS.Venus/Scer\GAL4^Ddc.PL partially rescues Ns3^G0431

(Kaplan et al., 2008)

atl^UAS.cLa/Scer\GAL4^Ddc.PL partially rescues atl¹

(Lee et al., 2008)

Scer\GAL4^Ddc.PL/Itpr^UAS.cVa partially rescues Itpr^ka901/Itpr^ug3

(Joshi et al., 2004)

Fails to rescue

Nf1^UAS.cdNa/Scer\GAL4^Ddc.PL fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Ns3^{K350N.UAS.Venus}/Scer\GAL4^Ddc.PL fails to rescue Ns3^G0431

(Hartl et al., 2013)

tutl^RE40452.UAS/Scer\GAL4^Ddc.PL fails to rescue tutl²³

(Zhou et al., 2012)

Adar^3.4.S.UAS/Scer\GAL4^Ddc.PL fails to rescue Adar^5G1

(Keegan et al., 2011)

Scer\GAL4^ple.PF, ple^FStrunc.UAS, Scer\GAL4^ple.PF, Scer\GAL4^Ddc.PL fails to rescue ple²

(Riemensperger et al., 2011)

Nf1^UAS.cWa/Scer\GAL4^Ddc.PL fails to rescue Nf1^unspecified

(Walker et al., 2006)

sbb^UAS.cYa/Scer\GAL4^Ddc.PL fails to rescue sbb⁰³⁴³²

(Suster et al., 2004)

Tbh^UAS.cMa/Scer\GAL4^Ddc.PL fails to rescue Tbh^nM18

(Monastirioti, 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

7010

w¹¹¹⁸; P{Ddc-GAL4.L}4.3D

7009

w¹¹¹⁸; P{Ddc-GAL4.L}Lmpt^4.36

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^Ddc.PL

ddc-GAL4

(Sykes et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (158)

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