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General Information
Symbol
Dmel\Ptp69DH24
Species
D. melanogaster
Name
FlyBase ID
FBal0104729
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G12739550A

Reported nucleotide change:

G?A

Amino acid change:

G1105R | Ptp69D-PA; G1104R | Ptp69D-PB

Reported amino acid change:

G1105R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G to A. Amino acid replacement: G1105R. Mutation replaces an invariant Gly residue flanking the active site of the first phosphatase domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

photoreceptor cell & axon | somatic clone

photoreceptor cell R1 & axon | somatic clone

photoreceptor cell R2 & axon | somatic clone

photoreceptor cell R3 & axon | somatic clone

photoreceptor cell R4 & axon | somatic clone

photoreceptor cell R5 & axon | somatic clone

photoreceptor cell R6 & axon | somatic clone

photoreceptor cell R7 & axon | somatic clone

Detailed Description
Statement
Reference

Photoreceptor fates are correctly specified, but their axons project abnormally into the optic lobes in homozygous clones in the eye. Some of the axons of R1-R6, which normally terminate in the lamina, instead continue through the lamina to terminate in the medulla, terminating at the same level as either the R8 or R7 axons. Frequent gaps in the array of R7 axon termini in the medulla are seen. 47% of R7 axons fail to reach their normal target layer in the medulla (although the R7 cell is missing in only 1% of ommatidia). Approximately 70% of R7 axons terminate prematurely within the medulla at the same level as the R8 axons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)