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General Information
Symbol
Dmel\DnaJ-1UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kazemi-Esfarjani
FlyBase ID
FBal0104861
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dhdJ1, UAS-DnaJ-1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of DnaJ-1 coding sequences.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The expression of DnaJ-1Scer\UAS.cKa under the control of Scer\GAL4lz-gal4 does not significantly affect the number or size of third instar larval circulating crystal cells.
Expression of DnaJ-1Scer\UAS.cKa in larval body wall sensory neurons under the control of Scer\GAL4RluA1 does not affect larval locomotion.
Flies expressing DnaJ-1Scer\UAS.cKa under the control of Scer\GAL4Mhc.PW show normal wing positions.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Suppressor of
Statement
Reference
DnaJ-1UAS.cKa, Scer\GAL4GMR.PU is a suppressor of retina | temperature conditional phenotype of Gug75QN.UAS, Scer\GAL4GMR.PU
Other
Additional Comments
Genetic Interactions
Statement
Reference
Expression of Gug75QN.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is suppressed by co-expression of DnaJ-1Scer\UAS.cKa.
Co-expression of DnaJ-1Scer\UAS.cKa suppresses of the eye degeneration phenotype caused by expression of Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.
Xenogenetic Interactions
Statement
Reference
Co-expression of DnaJ-1Scer\UAS.cKa suppresses lethality (adults survive 2-3 weeks) in flies with Hsap\CACNA1AScer\UAS.αACT.Q70 driven by Scer\GAL4sqh.PW. Co-expression of DnaJ-1Scer\UAS.cKa suppresses the progressive retinal degeneration seen in fly eyes with Hsap\CACNA1AScer\UAS.αACT.Q70 driven by Scer\GAL4GMR.PU.
Co-expression of DnaJ-1Scer\UAS.cKa suppresses eye degeneration (external and internal) in flies (both 1 day and 2 weeks old) with expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.long. Co-expression of Rad23KK107826, Hsap\ATXN3Scer\UAS.WT.T:Zzzz\His6, Hsap\ATXN3C14A.Scer\UAS.T:Zzzz\His6 or Hsap\ATXN3W87A.Scer\UAS.T:Zzzz\His6, Rpn8KK101319, Rpn11GD8888, simultaneous co-expression of Prosβ61.B.Scer\UAS and Prosβ21.Scer\UAS, or presence of Prosβ61 does not suppress the protective role of expression of DnaJ-1Scer\UAS.cKa in suppressing eye degeneration in flies with Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.long. Co-expression of HsfJF02415 suppresses the protective role of expression of DnaJ-1Scer\UAS.cKa in suppressing eye degeneration in flies with Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.long. Simultaneous co-expression of Prosβ61.B.Scer\UAS and Prosβ21.Scer\UAS leads to lethality in Scer\GAL4GMR.long>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies; extra co-expression of DnaJ-1Scer\UAS.cKa suppresses this lethality.
Co-expression of DnaJ-1Scer\UAS.cKa suppresses the rough eye and loss of eye pigmentation phenotypes seen in adults expressing Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.
Co-expression of DnaJ-1Scer\UAS.cKa with Hsap\HTT152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1 in larval body wall sensory neurons (under the control of Scer\GAL4RluA1) restores the speed of locomotion to wild-type levels.
Expression of DnaJ-1Scer\UAS.cKa in the developing eye under the control of Scer\GAL4GMR.PF suppresses the eye phenotype found in flies mutant for both Hsap\HTT152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP and Hsap\HTT48Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1.
Expression of DnaJ-1Scer\UAS.cKa partially suppresses the reduction in life expectancy seen when Hsap\HTTQ93.ex1p.Scer\UAS is expressed under the control of Scer\GAL4Eaat1.PR.
Coexpression of DnaJ-1Scer\UAS.cKa transgene results in a weak suppression of the wing posture phenotype of Scer\GAL4Mhc.PW>Hsap\PABPN117ala.Scer\UAS flies.
Co-expression of DnaJ-1Scer\UAS.cKa suppresses the short-lived phenotype of females expressing Zzzz\CAG63Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Appl.G1a.
The rough eye phenotype seen Hsap\ATX182.Scer\UAS, Scer\GAL4GMR.PF animals is suppressed by DnaJ-1Scer\UAS.cKa.
DnaJ-1Scer\UAS.cKa partially suppresses the rough eye phenotype of Hsap\ARQ52.Scer\UAS; Scer\GAL4GMR.PY animals treated with the androgen receptor ligand dihydroxytestosterone (DHT).
Complementation and Rescue Data
Comments
The expression of DnaJ-1Scer\UAS.cKa under the control of Scer\GAL4lz-gal4 rescues the increased number and size of circulating crystal cells present in DnaJ-1A/DnaJ-1C transheterozygous third instar larvae.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
DnaJ-1Scer\UAS.cKa
DnaJ-1UAS.cKa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Kazemi-Esfarjani
Secondary FlyBase IDs
    References (17)