FB2025_01 , released February 20, 2025
Allele: Dmel\BicDH3
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General Information
Symbol
Dmel\BicDH3
Species
D. melanogaster
Name
FlyBase ID
FBal0104887
Feature type
allele
Associated gene
Dmel\BicD
Associated Insertion(s)
Carried in Construct
P{BicD.H3}
Key Links
Transgenic product class
inframe_deletion
(Oh et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Oh et al., 2000)
Mutagen
in vitro construct
(Oh et al., 2000)
Progenitor genotype
BicD+m4
(Oh et al., 2000)
Carried in construct
P{BicD.H3}
Cytology
Description

Deletion of 70 amino acids (381-450), removing the H3 heptad repeat.

(Oh et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
BicD
Encoded product / tool
BicD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant ovaries consist of mostly wild-type egg chambers. Abnormal numbers of germ cells can be seen. In BicDH mutants the differentiation of the follicle cells is not affected, but the migration of the cells can be abnormal. During stage 2b Fas3 expressing follicle cells migrate between the interconnected cystocytes of the germline cysts, rather than migrating only on the surface of the cysts. Second, gaps in the follicle cell layer are occasionally detected in region 3 of the germarium. In BicDH mutants bipolar egg chambers are sometimes seen. Defects in the nuclear morphology of oocyte nuclei are seen, Occasionally polyploidy and intermediate polyploidy is seen in the oocyte nucleus of these egg chambers. The formation of the microtubule organising centre (MTOC) seen in germarial region 2a is normal.

      (Oh and Steward, 2001)

      ~1% of eggs laid by BicDH3, BicDr5/Df(2L)TW119 females display a mildly ventralised dorsal appendage phenotype.

      (Oh et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      BicDH3 partially rescues BicDr5

      (Oh et al., 2000)
      Comments

      Rescues zygotic viability of BicDr5/Df(2L)TW119 at rates ranging from 85% to 95%. Almost completely rescues the female sterility defect of BicDr5/Df(2L)TW119.

      (Oh et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bic-DH3
      (Oh and Steward, 2001)
      BicDH3
      (Delanoue and Davis, 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)