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General Information
Symbol
Dmel\mus304unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0104985
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The average number of apoptotic cells per larval wing disc is increased fourfold in mutant flies compared to wild type.

    The wing discs of mus304unspecified mutant third instar larvae exhibit similar levels of apoptosis to controls in response to X-ray induced irradiation. As in controls, very little apoptosis is seen in the absence of irradiation.

    24% of mutant embryos show uniform nuclear morphology and spacing as seen in interphase 14 in wild-type embryos, 16% are arrested at an early stage of embryogenesis, apparently between cycles 3 and 5 and have highly fragmented nuclei, and 60% show a complete or partial arrest at about cycle 14 with severe disruptions in nuclear morphology and spacing. Defects in nuclear divisions are visible during anaphase 12 and become more severe during cycles 13 and 14. Defects include asynchronous and incomplete chromosome segregation as well as fused and irregularly spaced nuclei during interphase. In 3 out of 6 embryos examined, interphase fails to lengthen until cycle 14 and interphase 14 is interrupted by a premature mitosis 14.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    mus304unspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (3)