FB2025_02 , released April 17, 2025
Allele: Dmel\HemJ1-70
Open Close
General Information
Symbol
Dmel\HemJ1-70
Species
D. melanogaster
Name
FlyBase ID
FBal0105156
Feature type
allele
Associated gene
Dmel\Hem
Associated Insertion(s)
Carried in Construct
Also Known As
ketteJ1-70
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Schenck et al., 2004, Hummel et al., 2000)
Mutagen
ethyl methanesulfonate
(Hummel et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: V927A.

(Hummel et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:22,285,143..22,285,143 [-]
Nucleotide change:

T22285143C

Amino acid change:

V927A | Hem-PA

Reported amino acid change:

V927A

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Hummel et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larval escapers have undergrown synapses at the neuromuscular junction compared to wild-type; overall synapse length is reduced to 85.8 μm in the mutant larvae compared to 111.1 μm in the wild type. HemJ1-70/HemΔ2-6 larvae have significantly shorter synapses at the neuromuscular junction (86.2 μm) compared to wild type (111.1 μm). The synaptic terminals have an abnormally high number of synaptic buds (5.1 compared to 1.6 buds per synapse in wild-type larvae).

      (Schenck et al., 2004)

      Mutant embryos show a subtle commissural and connective phenotype in the central nervous system.

      (Hummel et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series based on mutant phenotype; HemC3-20 = HemJ4-48 > HemP168 > HemG1-37 > HemJ1-70.

      (Hummel et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HemJ1-70
      KetteJI-70
      (Schenck et al., 2004)
      ketteJ1-070
      (Hummel et al., 2000)
      ketteJ1-70
      (Hamp et al., 2016, Schroter et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)