Open Close
General Information
Symbol
Dmel\HemJ1-70
Species
D. melanogaster
Name
FlyBase ID
FBal0105156
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ketteJ1-70
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T22285143C

Amino acid change:

V927A | Hem-PA

Reported amino acid change:

V927A

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: V927A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larval escapers have undergrown synapses at the neuromuscular junction compared to wild-type; overall synapse length is reduced to 85.8 μm in the mutant larvae compared to 111.1 μm in the wild type. HemJ1-70/HemΔ2-6 larvae have significantly shorter synapses at the neuromuscular junction (86.2 μm) compared to wild type (111.1 μm). The synaptic terminals have an abnormally high number of synaptic buds (5.1 compared to 1.6 buds per synapse in wild-type larvae).

Mutant embryos show a subtle commissural and connective phenotype in the central nervous system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Allelic series based on mutant phenotype; HemC3-20 = HemJ4-48 > HemP168 > HemG1-37 > HemJ1-70.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)