FlyBase Allele Report: Dmel\Hem[G1-37]

General Information

Symbol

Dmel\Hem^G1-37

Species

D. melanogaster

Name

FlyBase ID

FBal0105157

Feature type

allele

Associated gene

Dmel\Hem

Associated Insertion(s)

Carried in Construct

Also Known As

Kette^G1-37

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Schenck et al., 2004, Schroter et al., 2004)

Mutagen

ethyl methanesulfonate

(Hummel et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: H334L.

(Hummel et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:22,286,987..22,286,987 [-]

Nucleotide change:

A22286987T

Amino acid change:

H334L | Hem-PA

Reported amino acid change:

H334L

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Hummel et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Schenck et al., 2004)

Phenotype Manifest In

larval somatic muscle cell

(Schroter et al., 2004)

longitudinal trunk visceral muscle primordium (with Hem^J4-48)

(Rudolf et al., 2014)

muscle attachment site

(Schroter et al., 2004)

somatic muscle primordium

(Schroter et al., 2004)

Detailed Description

Statement

Reference

Hem^J4-48/Hem^G1-37 transheterozygote embryos display defects in the number, migration and morphology of visceral longitudinal muscle founder cells.

(Rudolf et al., 2014)

Unfused myoblasts are apparent in Hem^G1-37 mutant embryos until stage 15. By stage 16 hardly any unfused myoblasts are present, but there are large gaps in the muscle pattern and epidermal-muscle attachments are frequently missing or incorrect. Dorsal closure is normal in these embryos, as is formation of the dorsal vessel and cardioblasts.

(Schroter et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Hem^G1-37 has larval somatic muscle cell phenotype, enhanceable by blow[+]/blow²

(Schroter et al., 2004)

Hem^G1-37 has somatic muscle primordium phenotype, enhanceable by blow[+]/blow²

(Schroter et al., 2004)

NOT Enhancer of

Statement

Reference

Hem^G1-37 is a non-enhancer of larval somatic muscle cell phenotype of blow²

(Schroter et al., 2004)

Hem^G1-37 is a non-enhancer of somatic muscle primordium phenotype of blow²

(Schroter et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction of myoblast fusion seen in stage 15 Hem^G1-37/Hem^G1-37 embryos is enhanced by blow²/+. The muscle fusion phenotype of double homozygous blow²; Hem^G1-37 embryos resembles that of blow² homozygotes rather than Hem^G1-37 homozygotes.

(Schroter et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hem⁰³³³⁵

(Hummel et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series based on mutant phenotype; Hem^C3-20 = Hem^J4-48 > Hem^P168 > Hem^G1-37 > Hem^J1-70.

(Hummel et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hem^G1-37

Kette^G1-37

(Schroter et al., 2004)

Kette^GI-37

(Schenck et al., 2004)

kette^G1-037

(Hummel et al., 2000)

kette^G1-37

(Hamp et al., 2016, Rudolf et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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