FlyBase Allele Report: Dmel\Hem[Δ2-6]

General Information

Symbol

Dmel\Hem^Δ2-6

Species

D. melanogaster

Name

FlyBase ID

FBal0105159

Feature type

allele

Associated gene

Dmel\Hem

Associated Insertion(s)

Carried in Construct

Also Known As

kette^Δ2-6

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Schenck et al., 2004)

Mutagen

P-element activity

(Hummel et al., 2000)

Progenitor genotype

Hem⁰³³³⁵

(Hummel et al., 2000)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Schenck et al., 2004)

abnormal neuroanatomy (with Hem^J1-70)

(Schenck et al., 2004)

partially lethal

(Hummel et al., 2000)

Phenotype Manifest In

adult head & macrochaeta (with Hem^J4-48)

(Bogdan et al., 2004)

embryonic/larval neuromuscular junction (with Hem^J4-48)

(Bogdan et al., 2004)

lamina plexus

(Hummel et al., 2000)

larval neuromuscular junction & bouton (with Hem^J4-48)

(Bogdan et al., 2004)

medulla

(Hummel et al., 2000)

neuromuscular junction & synapse (with Hem^J1-70)

(Schenck et al., 2004)

photoreceptor cell & axon

(Hummel et al., 2000)

Detailed Description

Statement

Reference

Hem^J4-48/Hem^Δ2-6 larvae have reduced neuromuscular junctions with bulging, irregular boutons. About 15% of the heads of Hem^J4-48/Hem^Δ2-6 flies have one or more bent macrochaetae.

(Bogdan et al., 2004)

Hem^J1-70/Hem^Δ2-6 larvae have significantly shorter synapses at the neuromuscular junction (86.2 μm) compared to wild type (111.1 μm). The synaptic terminals have an abnormally high number of synaptic buds (5.1 compared to 1.6 buds per synapse in wild-type larvae).

(Schenck et al., 2004)

Homozygotes show reduced eclosion rates. Hem^Δ2-6/Hem^C3-20 animals almost never eclose. A weak disorganisation of the lamina plexus and an abnormal bundling of R-cell axons in the medulla is seen in approximately 70% of homozygous third instar larvae. 20% of the remaining larvae show a stronger disorganisation of the R-cell axons and 10% are indistinguishable from wild type. This axonal phenotype is more pronounced in Hem^Δ2-6/Hem^C3-20 larvae.

(Hummel et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Hem^Δ2-6 has photoreceptor cell & axon phenotype, enhanceable by dock[+]/dock¹³⁴²¹

(Hummel et al., 2000)

Enhancer of

Statement

Reference

Hem[+]/Hem^Δ2-6 is an enhancer of photoreceptor cell & axon phenotype of dock¹³⁴²¹

(Hummel et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of dock¹³⁴²¹ enhances the axonal projection phenotype of Hem^Δ2-6 homozygous larvae. One copy of Hem^Δ2-6 enhances the axonal projection phenotype of dock¹³⁴²¹ homozygous larvae.

(Hummel et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Hem^J1-70/Hem^Δ2-6 is rescued by Scer\GAL4^elav-C155/Hem^UAS.cHa

(Schenck et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hem^Δ2-6

Kette^Δ2-6

(Schenck et al., 2004)

kette^Δ2-6

(Bogdan et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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