Allele Dmel\Dcp-1^ΔN.GMR

General Information
Symbol	Dmel\Dcp-1^ΔN.GMR	Species	D. melanogaster
Name		FlyBase ID	FBal0105227
Feature type	allele	Associated gene	Dmel\Dcp-1

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Song et al., 2000) in vitro construct - regulatory fusion (Song et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A truncated Dcp-1, missing the N-terminal prodomain, is driven by GMR sequences. (Song et al., 2000)
Carried in construct	P{GMR-ΔN-Dcp-1} (Song et al., 2000, Mallik and Lakhotia, 2009, Leulier et al., 2006, Xu et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Mallik and Lakhotia, 2009) lethal \| pupal stage (Mallik and Lakhotia, 2009) visible (Song et al., 2000, Leulier et al., 2006, Xu et al., 2006)
Phenotype Manifest In
	eye (Song et al., 2000, Leulier et al., 2006, Xu et al., 2006, Mallik and Lakhotia, 2009) pigment cell (Song et al., 2000)
Detailed Description
	Statement Reference Dcp-1[DeltaN.GMR] eyes show complete loss of ommatidial integrity. 52% of Dcp-1[DeltaN.GMR] differentiated pupae die. (Mallik and Lakhotia, 2009) Dcp-1[ΔN.GMR] flies have a "spotted" eye phenotype. (Xu et al., 2006) Dcp-1^ΔN.GMR flies show a small and rough eye phenotype with pigment cell death. When two copies of P{GMR-ΔN-Dcp-1} are present the phenotype becomes stronger. The combination of Dcp-1^ΔN.GMR and Dcp-1^fl.GMR show an additive effect on the eye phenotype. (Song et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference Dcp-1^ΔN.GMR has visible phenotype, non-enhanceable by Scer\GAL4^GMR.PF/dream^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006) Dcp-1^ΔN.GMR has visible phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Nc^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006)
Suppressed by
Statement Reference Dcp-1^ΔN.GMR has eye color defective phenotype, suppressible by Scer\GAL4^GMR.PF/Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Dcp-1^ΔN.GMR has lethal \| pupal stage phenotype, suppressible by Scer\GAL4^GMR.PF/Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009)
NOT suppressed by
Statement Reference Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Ice¹⁷/Ice¹⁷ (Xu et al., 2006) Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Scer\GAL4^GMR.PF/dream^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006) Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Scer\GAL4^GMR.PF/Nc^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006)
Phenotype Manifest In
NOT Enhanced by
Statement Reference Dcp-1^ΔN.GMR has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/dream^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006) Dcp-1^ΔN.GMR has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Nc^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006) Dcp-1^ΔN.GMR has phenotype, non-enhanceable by Ice^fl.GMR (Song et al., 2000) Dcp-1^ΔN.GMR has phenotype, non-enhanceable by Ice^ΔN.GMR (Song et al., 2000)
Suppressed by
Statement Reference Dcp-1^ΔN.GMR has eye phenotype, suppressible by BacA\p35^GMR.PH (Song et al., 2000) Dcp-1^ΔN.GMR has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009)
NOT suppressed by
Statement Reference Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Ice¹⁷/Ice¹⁷ (Xu et al., 2006) Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF/dream^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006) Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF/Nc^{dsRNA.Scer\UAS.cLa} (Leulier et al., 2006)
NOT Enhancer of
Statement Reference Dcp-1^ΔN.GMR is a non-enhancer of phenotype of Ice^fl.GMR (Song et al., 2000) Dcp-1^ΔN.GMR is a non-enhancer of phenotype of Ice^ΔN.GMR (Song et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Scer\GAL4[GMR.PF]-mediated expression of P{Sym-UAS-Hsrω} nearly completely restores ommatidial integrity and eye pigmentation of Dcp-1[DeltaN.GMR] eyes. Pupal lethality is also suppressed. (Mallik and Lakhotia, 2009) The "spotted" eye phenotype caused by Dcp-1[ΔN.GMR] is not suppressed by homozygosity for Ice[17]. (Xu et al., 2006) The rough eye phenotype is suppressed by the addition of BacA\p35^GMR.PH. The addition of Dcp-1^ΔN.GMR to Ice^fl.GMR or Ice^ΔN.GMR flies has no effect on eye morphology. (Song et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Dcp-1^ΔN.GMR is rescued by Dcp-1^{dsRNA.Scer\UAS.cLa}/Scer\GAL4^GMR.PF (Leulier et al., 2006)
Comments	The eye phenotype observed in Dcp-1[ΔN.GMR] animals is rescued by expression of Dcp-1[dsRNA.Scer\UAS.cLa] under the control of Scer\GAL4[GMR.PF]. (Leulier et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Dcp-1^ΔN.GMR
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Mallik and Lakhotia, 2009, Genetics 183(3): 831--852 The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila. [FBrf0209343] Leulier et al., 2006, Cell Death Differ. 13(10): 1663--1674 Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. [FBrf0192581] Xu et al., 2006, Cell Death Differ. 13(10): 1697--1706 The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila. [FBrf0193497] Peterson et al., 2003, Dev. Biol. 260(1): 113--123 Stage-specific regulation of caspase activity in Drosophila oogenesis. [FBrf0160845] Song et al., 2000, Mol. Cell. Biol. 20(8): 2907--2914 Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. [FBrf0127334]

Allele Dmel\Dcp-1ΔN.GMR

Allele Dmel\Dcp-1^ΔN.GMR