Allele Dmel\Cdk7^{nos-D137R.bcd3'UTR}

General Information
Symbol	Dmel\Cdk7^{nos-D137R.bcd3'UTR}	Species	D. melanogaster
Name		FlyBase ID	FBal0105262
Feature type	allele	Associated gene	Dmel\Cdk7

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion, in vitro construct - amino acid replacement
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Leclerc et al., 2000) in vitro construct - coding region fusion (Leclerc et al., 2000) in vitro construct - regulatory fusion (Leclerc et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Amino acid replacement: D137R. The mutated Cdk7 cDNA is driven by the nos promoter and is tagged with the bcd 3'UTR. (Leclerc et al., 2000)
Carried in construct	P{nos-Cdk7.D137R.bcd3'UTR} (Leclerc et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryo (Leclerc et al., 2000) mitotic cell cycle \| anterior \| embryonic stage (Leclerc et al., 2000) mitotic cell cycle \| embryonic cycle 14 (Leclerc et al., 2000)
Detailed Description
	Statement Reference When Cdk7^{nos-D137R.bcd3'UTR} is expressed in early embryos, no modification or delay is seen in the timing of the first 13 nuclear divisions, however at the end of the maternal division program, a corresponding zone with twice the normal density of interphase 14 nuclei are observed, resulting from the appearance of an extra synchronous division in the domain of expression of the Cdk7^{D137R.Scer\UAS.T:Ivir\HA1} proteins. (Leclerc et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Cdk7^DN (Leclerc et al., 2000) Cdk7^{nos-D137R.bcd3'UTR}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Leclerc et al., 2000, EMBO J. 19(7): 1567--1575 Dominant-negative mutants reveal a role for the cdk7 kinase at the mid-blastula transition in Drosophila embryos. [FBrf0127187]

Allele Dmel\Cdk7nos-D137R.bcd3'UTR

Allele Dmel\Cdk7^{nos-D137R.bcd3'UTR}