FB2019_05, released Oct 15, 2019

Allele: Dmel\gloS011046

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General Information
Symbol
Dmel\gloS011046
Species
D. melanogaster
Name
FlyBase ID
FBal0105267
Feature type
allele
Associated gene
Dmel\glo
Associated Insertion(s)
P{lacW}gloS011046
Carried in Construct
Also Known As
l(3)S11046
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
3R:11,819,301..11,819,301
(Kalifa et al., 2006, Das, 2002.7.3, Kusano et al., 2001, Caggese, 2000.5.11, Deak, 1999.12.22, Szeged Stock Center, 1998-, Deak et al., 1997)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference
      P{lacW}gloS011046 is inserted in the 5'UTR of glo.
      (Kalifa et al., 2006)
      The P{lacW} insertion site is at 24th nucleotide of a 5' transcribed sequence (LD29934) of the glo gene.
      (Caggese, 2000.5.11)
      Insertion components
      P{lacW}gloS011046
      Product class / Tool use(s)
      Encoded product / tool
      lacZ
      Tagged with
      Tag:NLS(P)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      Over 60% of eggs produced by females with gloS011046 mutant ovaries (somatic clones) fail to develop beyond blastoderm stages. Between 10% and 20% of these display gross morphological defects, including abnormal dorsal appendages, collapsed appearance, or shortened egg length and are frequently unfertilised. Approximately 25% of eggs produced by females with gloS011046 mutant ovaries (somatic clones) develop to hatching, while a small and variable fraction (5-10%) show defects in anterior-posterior patterning, including loss of anterior structures, loss of abdominal segments, and bicaudal phenotypes.
      (Kalifa et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by
      gloS011046 is rescued by glog+t.5.6
      (Kalifa et al., 2006)
      gloS011046 is rescued by glog+t.4.5
      (Kalifa et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      110/46
      (Deak et al., 1997)
      CG6946S011046
      (Das, 2002.7.3, Caggese, 2000.5.11, Deak, 1999.12.22)
      gloS011046
      l(3)S011046S011046
      (Szeged Stock Center, 1998-)
      l(3)S11046
      (Kalifa et al., 2006, Kusano et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)