Allele Dmel\trio^M89

General Information
Symbol	Dmel\trio^M89	Species	D. melanogaster
Name		FlyBase ID	FBal0117288
Feature type	allele	Associated gene	Dmel\trio

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:1,024,942..1,024,942 evidence=experimental na_change=C1024942T pr_change=L1412F\|trio-PA,L1412F\|trio-PC reported_na_change=C?T reported_pr_change=L1412F (Liebl et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: C?T. Amino acid replacement: L1412F. (Liebl et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| prepupal stage (with Df(3L)Fpa1) (Liebl et al., 2000) neuroanatomy defective (with trio^IMP159.4) (Forsthoefel et al., 2005) viable (with trio^S036810) (Liebl et al., 2000) visible (with trio^S036810) (Liebl et al., 2000)
Phenotype Manifest In
	anterior commissure (with Df(3L)Fpa1) (Liebl et al., 2000) commissure (with trio^IMP159.4) (Forsthoefel et al., 2005) longitudinal connective (with Df(3L)Fpa1) (Liebl et al., 2000) posterior commissure (with Df(3L)Fpa1) (Liebl et al., 2000) wing (with trio^S036810) (Liebl et al., 2000)
Detailed Description
	Statement Reference 4.8% of segments have thin/missing commissures and 5.1% of segment have commissures with pathfinding errors in trio^IMP159.4/trio^M89 embryos. (Forsthoefel et al., 2005) Heterozygotes with Df(3L)Fpa1 show mild irregularities in the commissures and longitudinal connectives of the embryonic central nervous system. Heterozygotes of trio^S036810/trio^M89 show a wing blister phenotype but are otherwise wild type. (Liebl et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference trio^M89/trio^S036810 has lethal phenotype, enhanceable by Abl¹/Abl[+] (Liebl et al., 2000) trio^M89/trio^S036810 has lethal phenotype, enhanceable by Abl⁴/Abl[+] (Liebl et al., 2000) trio^M89/trio^S036810 has lethal phenotype, enhanceable by fax^M7/fax[+] (Liebl et al., 2000)
NOT Enhanced by
Statement Reference trio^M89/trio^IMP159.4 has neuroanatomy defective phenotype, non-enhanceable by fra⁴/fra[+] (Forsthoefel et al., 2005)
Suppressed by
Statement Reference Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has neuroanatomy defective phenotype, suppressible \| partially by ena[+]/ena^GC10 (Forsthoefel et al., 2005) Abl⁴/Abl¹, trio[+]/trio^M89 has lethal \| prepupal stage phenotype, suppressible by ena[+]/ena^GC10 (Liebl et al., 2000) Df(3L)Fpa1/trio^M89 has lethal phenotype, suppressible \| partially by ena[+]/ena^GC10 (Liebl et al., 2000)
Enhancer of
Statement Reference trio[+]/trio^M89 is an enhancer of lethal \| prepupal stage phenotype of Abl⁴/Abl¹ (Liebl et al., 2000) trio[+]/trio^M89 is an enhancer of neuroanatomy defective phenotype of Df(2R)vg135/fra⁴ (Forsthoefel et al., 2005) trio[+]/trio^M89 is an enhancer of neuroanatomy defective phenotype of fra⁴ (Forsthoefel et al., 2005) trio^M89/trio^IMP159.4 is an enhancer of neuroanatomy defective phenotype of Df(2R)vg135/fra⁴ (Forsthoefel et al., 2005) trio^M89/trio^IMP159.4 is an enhancer of neuroanatomy defective phenotype of fra⁴ (Forsthoefel et al., 2005) trio^M89/trio^S036810 is an enhancer of neuroanatomy defective phenotype of fra⁴ (Forsthoefel et al., 2005)
Other
Statement Reference Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has neuroanatomy defective phenotype (Forsthoefel et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference Df(3L)Fpa1/trio^M89 has anterior commissure phenotype, enhanceable by Abl¹/Abl[+] (Liebl et al., 2000) Df(3L)Fpa1/trio^M89 has longitudinal connective phenotype, enhanceable by Abl¹/Abl[+] (Liebl et al., 2000) Df(3L)Fpa1/trio^M89 has posterior commissure phenotype, enhanceable by Abl¹/Abl[+] (Liebl et al., 2000) trio^M89/trio^S036810 has longitudinal connective phenotype, enhanceable by Abl¹/Abl[+] (Liebl et al., 2000)
NOT Enhanced by
Statement Reference trio^M89/trio^IMP159.4 has commissure phenotype, non-enhanceable by fra⁴/fra[+] (Forsthoefel et al., 2005)
Suppressed by
Statement Reference Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has commissure phenotype, suppressible \| partially by ena[+]/ena^GC10 (Forsthoefel et al., 2005)
Enhancer of
Statement Reference trio[+]/trio^M89 is an enhancer of anterior commissure phenotype of Abl⁴/Abl¹ (Liebl et al., 2000) trio[+]/trio^M89 is an enhancer of commissure phenotype of Df(2R)vg135/fra⁴ (Forsthoefel et al., 2005) trio[+]/trio^M89 is an enhancer of commissure phenotype of fra⁴ (Forsthoefel et al., 2005) trio[+]/trio^M89 is an enhancer of longitudinal connective phenotype of Abl⁴/Abl¹ (Liebl et al., 2000) trio[+]/trio^M89 is an enhancer of posterior commissure phenotype of Abl⁴/Abl¹ (Liebl et al., 2000) trio^M89/trio^IMP159.4 is an enhancer of commissure phenotype of Df(2R)vg135/fra⁴ (Forsthoefel et al., 2005) trio^M89/trio^IMP159.4 is an enhancer of commissure phenotype of fra⁴ (Forsthoefel et al., 2005) trio^M89/trio^S036810 is an enhancer of commissure phenotype of fra⁴ (Forsthoefel et al., 2005)
NOT Enhancer of
Statement Reference trio^M89/trio^IMP159.4 is a non-enhancer of longitudinal connective phenotype of Df(2R)vg135/fra⁴ (Forsthoefel et al., 2005)
Suppressor of
Statement Reference trio[+]/trio^M89 is a suppressor of eye disc & S phase phenotype of CycE^JP (Brumby et al., 2004) trio[+]/trio^M89 is a suppressor of eye phenotype of CycE^JP (Brumby et al., 2004)
Other
Statement Reference Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has commissure phenotype (Forsthoefel et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Dominantly suppresses the S phase defects seen in the CycE^JP eye disc. (Brumby et al., 2004) The suppression of prepupal lethality of trio^M89/Df(3L)Fpa1 by ena^GC10 is incomplete. Lethality is delayed until pupariation, but adults are never recovered. (Liebl et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	trio^S036810 (Liebl et al., 2000)
Rescued by	Df(3L)Fpa1/trio^M89 is rescued by trio^Scer\UAS.cLa/Scer\GAL4^sca-537.4 (Liebl et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	trio^M89 (Liebl et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Forsthoefel et al., 2005, Development 132(8): 1983--1994 The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. [FBrf0183931] Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Liebl et al., 2000, Neuron 26(1): 107--118 Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. [FBrf0127511]
Abstract	Liebl et al., 2007, A. Dros. Res. Conf. 48: 566B A screen for dominant enhancers of a trio mutant phenotype. [FBrf0198074] Liebl et al., 2005, A. Dros. Res. Conf. 46: 638B A screen for dominant enhancers of a trio mutant phenotype. [FBrf0183116]

Allele Dmel\trioM89

Allele Dmel\trio^M89