FlyBase Allele Report: Dmel\tld[MBT]

General Information

Symbol

Dmel\tld^MBT

Species

D. melanogaster

Name

FlyBase ID

FBal0117332

Feature type

allele

Associated gene

Dmel\tld

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | temperature conditional (with tld¹)

(Riede, 2001)

some die during pupal stage | temperature conditional (with tld¹)

(Riede, 2001)

visible (with tld¹)

(Riede, 2001)

Phenotype Manifest In

brain (with tld¹)

(Riede, 2001)

ommatidium (with tld¹)

(Riede, 2001)

polytene chromosome

(Riede, 1996)

Detailed Description

Statement

Reference

tld^MBT/tld¹ hybrids have rough eyes at the permissive temperature. At the restrictive temperature, 30% die as pupae. The optic lobes are not hyperplastic, brain cells are differentiated but do not adhere.

(Riede, 2001)

Mutants show somatic pairing defects in the salivary gland chromosomes. The frequency with which the chromosome remains unpaired is increased in yeti^MBT, tld^MBT double mutants.

(Riede, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tld^MBT has neoplasia | heat sensitive phenotype, enhanceable by spz^MBT/yeti-MBT^MBT

(Riede, 1996)

Enhancer of

Statement

Reference

yeti-MBT^MBT/tld^MBT is an enhancer of neoplasia | heat sensitive phenotype of spz^MBT

(Riede, 1996)

spz^MBT/tld^MBT is an enhancer of neoplasia | heat sensitive phenotype of yeti-MBT^MBT

(Riede, 1996)

Other

Statement

Reference

tld^MBT, yeti-MBT^MBT has lethal | pupal stage phenotype

(Riede, 2001)

tld^MBT, yeti-MBT^MBT has hyperplasia phenotype

(Riede, 2001)

spz^MBT, tld^MBT, yeti-MBT^MBT has lethal | larval stage phenotype

(Riede, 2001)

spz^MBT, tld^MBT, yeti-MBT^MBT has neoplasia phenotype

(Riede, 2001)

mali^MBT, spz^MBT, tld^MBT, yeti-MBT^MBT has lethal | larval stage phenotype

(Riede, 2001)

mali^MBT, spz^MBT, tld^MBT, yeti-MBT^MBT has neoplasia phenotype

(Riede, 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

tld^MBT has adult brain phenotype, enhanceable by spz^MBT/yeti-MBT^MBT

(Riede, 1996)

Enhancer of

Statement

Reference

yeti-MBT^MBT/tld^MBT is an enhancer of adult brain phenotype of spz^MBT

(Riede, 1996)

spz^MBT/tld^MBT is an enhancer of adult brain phenotype of yeti-MBT^MBT

(Riede, 1996)

Other

Statement

Reference

spz^MBT, tld^MBT, yeti-MBT^MBT has larval brain phenotype

(Riede, 2001)

mali^MBT, spz^MBT, tld^MBT, yeti-MBT^MBT has larval brain phenotype

(Riede, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

At the restrictive temperature of 29^oC, mali^MBT tld^MBT yeti^MBT spz^MBT mutants show 100% lethality during the third larval instar. Third instar larvae have brain tumours of undifferentiated tissue. If these animals are rescued with tld^+t12, they show 100% pupal lethality and hyperplastic brains at the restrictive temperature. At the restrictive temperature of 29^oC, tld^MBT yeti^MBT mutants show 90% pupal lethality. The brain of third instar larvae is hyperplastic. If these animals are rescued with tld^+t12, they show 30% pupal lethality and normal brains at the restrictive temperature. At the restrictive temperature of 29^oC, tld^MBT yeti^MBT spz^MBT mutants show 100% lethality during the third larval instar. Third instar larvae have brain tumours of undifferentiated tissue. If these animals are rescued with tld^+t12, they show 60% pupal lethality and hyperplastic brains at the restrictive temperature.