Allele Dmel\sisA²

General Information
Symbol	Dmel\sisA²	Species	D. melanogaster
Name		FlyBase ID	FBal0117360
Feature type	allele	Associated gene	Dmel\sisA

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Walker et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation X:11,215,843..11,215,843 evidence=experimental na_change=C11215843T pr_change=Q161@\|sisA-PA reported_na_change=C?T reported_pr_change=Q161@ (Walker et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: C?T. Amino acid replacement: Q161@. (Walker et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| male \| recessive (Walker et al., 2000) lethal \| female \| recessive (Walker et al., 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference Mutant clones in gynandromorphs are recovered in every adult structure with similar frequency. The average size of the null mutant patches is quite large. Many mosaics have more than half male tissue and some are almost entirely male. (Walker et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference sisA²/sisA¹ has lethal \| female phenotype, suppressible by Sxl^M4 (Walker et al., 2000)
NOT suppressed by
Statement Reference sisA² has lethal \| recessive \| female phenotype, non-suppressible by Sxl^M4 (Walker et al., 2000)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	sisA¹ (Walker et al., 2000)
Rescued by	sisA² is rescued by sisA^+t6.4 (Walker et al., 2000)
Not rescued by	sisA² is not rescued by sisA^A10m2 (Walker et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sisA²
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Walker et al., 2000, Genetics 155(1): 191--202 The Drosophila melanogaster sex determination gene sisA is required in yolk nuclei for midgut formation. [FBrf0127377]

Allele Dmel\sisA2

Allele Dmel\sisA²