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General Information
Symbol
Dmel\sbb4
Species
D. melanogaster
Name
FlyBase ID
FBal0117380
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

436bp deletion in the sbb third exon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

photoreceptor cell R1 & neuron

photoreceptor cell R2 & neuron

photoreceptor cell R3 & neuron

photoreceptor cell R4 & neuron

photoreceptor cell R5 & neuron

photoreceptor cell R6 & neuron

Detailed Description
Statement
Reference

Third instar larvae homozygous for sbb4 or transheterozygous for sbb03432/sbb4 display a significant increase in turning rate during crawling, as compared to controls.

In contrast to the wild-type, in mutant larvae, the lamina plexus is discontinuous. Thick bundles of axons are frequently observed between the lamina and the medulla, in striking contrast to the thin bundles in wild-type. In the most severe cases, the lamina plexus is largely missing and the medulla neuropil is hyperinnervated. In addition, disruptions in the normally smooth topographic map in then medulla are observed. However R-cell projections do not extend through the medulla into deeper layers of the optic lobe, suggesting that R8 neurons terminate, as in wild-type, within the medulla neuropil. R-cell fate and neuronal differentiation occurs normally in sbb4 mutants. Also photoreceptor arrangement remains normal, in almost all ommatidia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Phenotypic analysis suggests an allelic series: sbb4 >= sbbk06903b > sbb5 = sbbk00702 > sbb04440.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)