Allele Dmel\rin¹

General Information
Symbol	Dmel\rin¹	Species	D. melanogaster
Name		FlyBase ID	FBal0117391
Feature type	allele	Associated gene	Dmel\rin

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Pazman et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} insertion in an alternative exon in the 5' UTR. (Pazman et al., 2000)
Caused by insertion	P{lacW}rin¹ (Pazman et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective \| recessive (Pazman et al., 2000) viable (Pazman et al., 2000) viable (with rin²) (Pazman et al., 2000) visible (with rin²) (Pazman et al., 2000) visible \| recessive (Pazman et al., 2000)
Phenotype Manifest In
	eye (Pazman et al., 2000) eye (with rin²) (Pazman et al., 2000) eye disc (Pazman et al., 2000) eye photoreceptor cell (Pazman et al., 2000) ommatidium (Pazman et al., 2000) ommatidium (with rin²) (Pazman et al., 2000)
Detailed Description
	Statement Reference Homozygotes and rin¹/rin² flies are viable and show a mild rough eye phenotype. Homozygous eyes show defects in both photoreceptor recruitment and ommatidial polarity. Many ommatidia have fewer than the wild-type complement of 8 photoreceptors and some have extra photoreceptors. Both inner and outer photoreceptors can be affected. Many mutant ommatidia with the normal complement of photoreceptors show polarity defects; both the degree and direction of rotation and the chirality of the ommatidia can be affected. The recruitment and polarity defects are evident in third larval instar imaginal discs. (Pazman et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference rin¹/rin[+] is a suppressor of visible phenotype of Ras85D^V12.sev (Pazman et al., 2000) rin¹/rin[+] is a suppressor of visible phenotype of svp^2.sev (Pazman et al., 2000)
Phenotype Manifest In
Enhancer of
Statement Reference rin¹/rin[+] is an enhancer of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶ (Pazman et al., 2000)
NOT Enhancer of
Statement Reference rin¹ is a non-enhancer of phenotype of RasGAP1^1-16 (Pazman et al., 2000) rin¹ is a non-enhancer of phenotype of RasGAP1^Scer\UAS.cGa, Scer\GAL4^hs.2sev (Pazman et al., 2000)
Suppressor of
Statement Reference rin¹/rin[+] is a suppressor of eye phenotype of Ras85D^V12.sev (Pazman et al., 2000) rin¹/rin[+] is a suppressor of eye phenotype of svp^2.sev (Pazman et al., 2000) rin¹/rin[+] is a suppressor of ommatidium phenotype of sev^{S11.T:Hsap\MYC} (Pazman et al., 2000) rin¹/rin[+] is a suppressor of phenotype of sev^{S11.T:Hsap\MYC} (Pazman et al., 2000) rin¹/rin[+] is a suppressor of photoreceptor cell R7 \| ectopic phenotype of sev^{S11.T:Hsap\MYC} (Pazman et al., 2000)
NOT Suppressor of
Statement Reference rin¹ is a non-suppressor of phenotype of phl::tor^12D.sev (Pazman et al., 2000) rin¹ is a non-suppressor of phenotype of RasGAP1^1-16 (Pazman et al., 2000) rin¹ is a non-suppressor of phenotype of RasGAP1^Scer\UAS.cGa, Scer\GAL4^hs.2sev (Pazman et al., 2000) rin¹ is a non-suppressor of phenotype of rl^Sem (Pazman et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference The extra R7 photoreceptor cells seen in flies carrying sev^{S11.T:Hsap\MYC} are reduced to an average of 2.71 +/- 0.23 R7 photoreceptor cells per ommatidium if the flies are also carrying rin¹. 18.7% of ommatidia have an R7 cell in sev⁶; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹; 13.9% of ommatidia have an R7 cell in sev⁶; Sos^JC2/+ ; rin¹/+ flies. (Pazman et al., 2000) 28.7% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶ ; Sos^JC2/+ ; rin²/+ flies respectively. (Pazman et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	rin¹/rin² is rescued by rin^Tub.PP (Pazman et al., 2000) rin¹ is rescued by rin^Tub.PP (Pazman et al., 2000)
Comments
Stocks ( 1 )
Bloomington	9302 w^*; P{lacW}rin¹
Notes on Origin
Discoverer
	Selected as: a modifier of the svp^2.sev eye phenotype. (Pazman et al., 2000)
Comments
	The rin¹ homozygous phenotype and the dominant suppression of the svp^2.sev eye phenotype are revertable on excision of the P-element. (Pazman et al., 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	P4957 (Pazman et al., 2000) rin¹ rin^P (Pazman et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Pazman et al., 2000, Development 127(8): 1715--1725 Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and -mediated signaling. [FBrf0127269]

Allele Dmel\rin1

Allele Dmel\rin¹