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General Information
Symbol
Dmel\mer-on-314
Species
D. melanogaster
Name
FlyBase ID
FBal0117440
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
merlin14
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Shows lethality from the first to third larval instar when heterozygous with the MBT chromosome. Brain tumours are seen.

Lethal and tumour inducing over the MBT chromosome. Homozygotes die during the third larval instar. merpi9/mer14 animals are viable. Homozygotes show the formation of melanotic tumours. Gaps in somatic pairing are seen in the polytene chromosomes of heterozygous salivary glands. Heterozygotes show resistance to 1mM methyl methanesulfonate but not to 5mM hydroxyurea.

Shows strong somatic pairing defect in the salivary chromosomes. Causes significant melanotic tumor formation in larvae. Shows tumor formation when heterozygous with the MBT chromosome. Lethal when heterozygous with the MBT chromosome.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

mer-on-314 is an enhancer of lethal | embryonic stage phenotype of AntpAus

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

pll8 mer14 induces neoplasms. mer14 Df(3R)Espl1 results in anal plate neoplasms.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
mer-on-314
mer14
merlin14
Name Synonyms
merlin14
Secondary FlyBase IDs
    References (4)