Q134term | Cdk2-PA; Q134term | Cdk2-PB; Q134term | Cdk2-PC
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
The frequency of aberrant type III axon innervation patterns in body-wall muscle 13 of third instar larvae single heterozygous for either Cdk23 or rl1 is mutually enhanced in the double heterozygotes.
cdc2c1/cdc2c3 and cdc2c2/cdc2c3 larvae survive for at least 4 days after egg deposition, but their size fails to increase significantly after 1.5 days (in contrast to wild-type larvae). cdc2c2/cdc2c3 females that have been rescued by periodic expression of cdc2chs.PS readily lay eggs as long as they are subjected to periodic heat shocks (to induce expression of cdc2chs.PS). However, after termination of periodic heat shocks, egg deposition decreases rapidly and stops completely within 2-3 days. This arrest of egg deposition can be readily reversed within 7 days after resumption of periodic heat shocks. Eggs collected from females 1 day after termination of periodic heat shocks often show abnormal spatial distribution of nuclei and the chromatin often appears abnormal. A significant fraction of embryos contain very few nuclei. About two-thirds of eggs with less than 5 nuclei are not fertilised. Periodic expression of cdc2chs.PS (using heat shock) in cdc2c2/cdc2c3 animals allows them to develop into morphologically normal and fertile adults. Some animals are still observed to develop into adults even if the onset of periodic expression of cdc2chs.PS is delayed until 116 hours after egg deposition.