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General Information
Symbol
Dmel\Cdk23
Species
D. melanogaster
Name
FlyBase ID
FBal0117571
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C20736416T

Amino acid change:

Q134term | Cdk2-PA; Q134term | Cdk2-PB; Q134term | Cdk2-PC

Reported amino acid change:

Q134term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q134term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cdk23 homozygous (and with a lower penetrance also heterozygous) mutant third instar larvae display high frequency of ectopic targetting of type III axons to the abdominal body-wall muscle 13.

Hemizygous embryos appear to have wild-type morphology. They incorporate BrdU with normal efficiency and in normal patterns throughout embryogenesis. Hatching of larvae occurs at the same rate as that of control embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

Cdk23/cdc2c[+] is a non-enhancer of visible phenotype of mi1/miΔEY22

Suppressor of
Statement
Reference

Cdk23/cdc2c[+] is a suppressor of visible | dominant phenotype of Snr1E1

Cdk23/cdc2c[+] is a suppressor of visible phenotype of CycEI.hs.2sev

NOT Suppressor of
Statement
Reference

Cdk23/cdc2c[+] is a non-suppressor of visible phenotype of mi1/miΔEY22

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

Cdk23/cdc2c[+] is a non-enhancer of macrochaeta & thorax phenotype of mi1/miΔEY22

Suppressor of
Statement
Reference

Cdk23/cdc2c[+] is a suppressor of wing vein | ectopic phenotype of Snr1E1

Cdk23/cdc2c[+] is a suppressor of wing phenotype of Snr1E1

Cdk23/cdc2c[+] is a suppressor of eye phenotype of CycEI.hs.2sev

Cdk23/cdc2c[+] is a suppressor of ommatidium phenotype of CycEI.hs.2sev

NOT Suppressor of
Statement
Reference

Cdk23/cdc2c[+] is a non-suppressor of macrochaeta & thorax phenotype of mi1/miΔEY22

Additional Comments
Genetic Interactions
Statement
Reference

The frequency of aberrant type III axon innervation patterns in body-wall muscle 13 of third instar larvae single heterozygous for either Cdk23 or rl1 is mutually enhanced in the double heterozygotes.

Heterozygosity for either cdc2c2 or cdc2c3 has no effect on the small bristle phenotype of mi1/miΔEY22 flies.

Adult viability of CycD1/Y ; cdc2c3/+ males is 0%.

At 29oC, cdc2c3/+ suppresses the ectopic wing vein phenotype of Snr1E1/+; 100% of the flies have wild-type wings.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

cdc2c1/cdc2c3 and cdc2c2/cdc2c3 larvae survive for at least 4 days after egg deposition, but their size fails to increase significantly after 1.5 days (in contrast to wild-type larvae). cdc2c2/cdc2c3 females that have been rescued by periodic expression of cdc2chs.PS readily lay eggs as long as they are subjected to periodic heat shocks (to induce expression of cdc2chs.PS). However, after termination of periodic heat shocks, egg deposition decreases rapidly and stops completely within 2-3 days. This arrest of egg deposition can be readily reversed within 7 days after resumption of periodic heat shocks. Eggs collected from females 1 day after termination of periodic heat shocks often show abnormal spatial distribution of nuclei and the chromatin often appears abnormal. A significant fraction of embryos contain very few nuclei. About two-thirds of eggs with less than 5 nuclei are not fertilised. Periodic expression of cdc2chs.PS (using heat shock) in cdc2c2/cdc2c3 animals allows them to develop into morphologically normal and fertile adults. Some animals are still observed to develop into adults even if the onset of periodic expression of cdc2chs.PS is delayed until 116 hours after egg deposition.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: a dominant modifier of the CycEI.hs.2sev rough eye phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)