30 day old Thor²/Thor² mutants show significant loss of dopaminergic PPL1 neurons compared to controls.

(Tain et al., 2009)

After 30 days of light/dark cycling, photoreceptors are preserved normally in Thor² flies.

(Wang et al., 2009)

Thor² mutant flies, when deprived of all sources of energy die faster than control flies. At 37 hours of starvation, 92% of control flies are alive, whereas only 38% of Thor² mutant flies survive. This difference is statistically significant. Thor² mutant flies may have slightly higher fat levels than in wild-type in normal conditions. Triglyceride stores drop more rapidly in Thor² mutant flies than in wild-type controls. By 24 hours of starvation, the difference in fat content is statistically significant. At 36 hours of starvation, the fat content of Thor² mutants reaches almost zero, whereas control flies still have a substantial amount of fat left at this stage. The time at which the flies have no fat left coincides with when they start dying. After 30 hours of starvation, control flies have >25% of their original fat content, whereas Thor² flies have only half as much, indicating an increased burn rate compared to wild-type. Thor² mutants do not accumulate as much excess fat as wild-type in response to the Tor-inhibitor rapamycin. In conditions of nutrient deprivation, upon addition of rapamycin, the half-life of Thor² mutants is extended by 43 hours, compared to 55 hours in wild-type. Thor² mutant flies are comparable in body weight and developmental rate to wild-type flies.

(Teleman et al., 2005)

Homozygous flies have no obvious morphological defects.

(Bernal et al., 2004)

4 days after infection with S. epidermis only 47% of mutant flies survive, compared to over 80% in wild-type. 4 days after infection with M. roseus, 16% of mutant flies survive as compared to 46% in wild-type.

(Bernal and Kimbrell, 2000)

Thor², park²⁵ has partially lethal - majority die phenotype, suppressible by Scer\GAL4^da.PU/Thor^UAS.cMa

(Tain et al., 2009)

Pink1^B9, Thor² has partially lethal - majority live phenotype, suppressible by Scer\GAL4^da.PU/Thor^UAS.cMa

(Tain et al., 2009)

Thor², Trpml¹ has lethal | pupal stage phenotype

(Wong et al., 2012)

Thor², park²⁵ has partially lethal - majority die phenotype

(Tain et al., 2009)

Pink1^B9, Thor² has partially lethal - majority live phenotype

(Tain et al., 2009)