Allele Dmel\N^{1893-2155.Scer\UAS}

General Information
Symbol	Dmel\N^{1893-2155.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0117698
Feature type	allele	Associated gene	Dmel\N

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Wesley and Saez, 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the CDC10/ankyrin repeat region of the intracellular domain of N. (Wesley and Mok, 2003) Construct: Scer\UAS regulatory sequences drive expression of a portion of N. (Wesley and Saez, 2000)
Carried in construct	P{UAS-N.1893-2155} (Wesley and Saez, 2000, Wesley and Mok, 2003, Kuzina et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage, with Scer\GAL4^Act.PU (Wesley and Mok, 2003) lethal \| embryonic stage, with Scer\GAL4^arm.PS (Wesley and Mok, 2003) lethal \| embryonic stage, with Scer\GAL4^da.G32 (Wesley and Mok, 2003) lethal \| embryonic stage, with Scer\GAL4^hs.PB (Wesley and Mok, 2003)
Phenotype Manifest In

Detailed Description
	Statement Reference Expression of N^{1893-2155.Scer\UAS} under the control of Scer\GAL4^hs.PB, Scer\GAL4^da.G32, Scer\GAL4^arm.PS or Scer\GAL4^Act causes the majority of embryos to fail to hatch into larvae and epidermis to be produced at the expense of CNS tissue. (Wesley and Mok, 2003)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	Scer\GAL4^15J2/N^{1893-2155.Scer\UAS} partially rescues N^l1N-ts1 (Kuzina et al., 2011)
Comments	Expression of N[1893-2155.Scer\UAS] in pioneer neurons under the control of Scer\GAL4[15J2] partially rescues axon extension in N[l1N-ts1] mutant embryos. (Kuzina et al., 2011)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in plasmid "UAS-N^1893-2155" and transfected into S2 cells with an Scer\GAL4 driver plasmid. (Wesley and Saez, 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	N^{1893-2155.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Wesley and Mok, 2003, Mol. Cell. Biol. 23(16): 5581--5593 Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated Notch. [FBrf0162239] Wesley and Saez, 2000, J. Cell Biol. 149(3): 683--696 Analysis of Notch lacking the carboxyl terminus identified in Drosophila embryos. [FBrf0127388]

Allele Dmel\N1893-2155.Scer\UAS

Allele Dmel\N^{1893-2155.Scer\UAS}