FlyBase Allele Report: Dmel\Jra[Asp.B.UAS]

General Information

Symbol

Dmel\Jra^Asp.B.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0117715

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

P{UAS-jun^Asp.B}

Also Known As

UAS-DJUN^aspv7, UAS-jun^aspv7

Key Links

Transgenic product class

missense_variant

(Szuts and Bienz, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Szuts and Bienz, 2000)

Mutagen

in vitro construct

(Szuts and Bienz, 2000)

Progenitor genotype

Jra^Asp.hs.sev

(Szuts and Bienz, 2000)

Carried in construct

P{UAS-jun^Asp.B}

Cytology

Description

An activated form of Jra is driven by UAS sequences.

(Szuts and Bienz, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Jra

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Tare et al., 2011)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

modeled by Hsap\APP^2xAPP.SP.UAS

(Sarkar et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Detailed Description

Statement

Reference

Expression of Jra^{Asp.B.Scer\UAS} under the control of Scer\GAL4^ey.PH does not affect the eye.

(Singh et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, enhanceable by Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^pnr-MD237 has lethal | embryonic stage phenotype, suppressible | partially by Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Jra^Asp.B.UAS, Scer\GAL4^ey.PH has lethal | prepupal stage phenotype, suppressible | partially by Mnn1^UAS.cCa, Scer\GAL4^ey.PH

(Cerrato et al., 2006)

Enhancer of

Statement

Reference

Jra^Asp.B.UAS, Scer\GAL4^GMR.long is an enhancer of increased cell death | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of decreased size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of increased cell death | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.PU is an enhancer of increased cell death phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Jra^Asp.B.UAS, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has melanotic necrosis | adult stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype

(Deshpande et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Enhancer of

Statement

Reference

Jra^Asp.B.UAS, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.long is an enhancer of eye disc | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Scer\GAL4^GMR.long, Jra^Asp.B.UAS is an enhancer of eye disc | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Scer\GAL4^GMR.PU is an enhancer of eye disc phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Jra^Asp.B.UAS, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Jra^Asp.B.UAS/Scer\GAL4^ey.PH is an enhancer of eye disc | ventral phenotype of L²

(Singh et al., 2006)

Jra^Asp.B.UAS/Scer\GAL4^ey.PH is an enhancer of eye | ventral phenotype of L²

(Singh et al., 2006)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye disc | larval stage phenotype

(Deshpande et al., 2023)

Jra^Asp.B.UAS, Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237 has adult thorax phenotype

(Cerrato et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of Mnn1^Scer\UAS.cCa and Jra^{Asp.B.Scer\UAS} under the control of Scer\GAL4^pnr-MD237 results in 1-5% of flies escaping the Jra^{Asp.B.Scer\UAS} lethality to eclose. Viable flies have a severe cleft thorax. Likewise, the prepupal lethality of Scer\GAL4^ey.PH>Jra^{Asp.B.Scer\UAS} flies is partially suppressed when Mnn1^Scer\UAS.cCa is coexpressed.

(Cerrato et al., 2006)

Expression of Jra^{Asp.B.Scer\UAS} under the control of Scer\GAL4^ey.PH results in a strong enhancement of the L²/+ eye phenotype to a very small eye or no eye in 36% of flies.

(Singh et al., 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of Jra^{Asp.B.Scer\UAS} enhances the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and results in adults having a severe reduced eye phenotype.

(Tare et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Jra^{Asp.B.Scer\UAS}

Jra^Asp.B.UAS

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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