FB2025_01 , released February 20, 2025
Allele: Dmel\IswiK159R.Tag:HA
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General Information
Symbol
Dmel\IswiK159R.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0117723
Feature type
allele
Associated gene
Dmel\Iswi
Associated Insertion(s)
Carried in Construct
P{IswiK159R.T:Ivir\HA1}
Key Links
Transgenic product class
dominant_negative_variant
(Deuring et al., 2000)
missense_variant
(Deuring et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Deuring et al., 2000)
missense_variant
(Deuring et al., 2000)
Mutagen
in vitro construct
(Deuring et al., 2000)
Progenitor genotype
IswiTag:HA
(Deuring et al., 2000)
Carried in construct
P{IswiK159R.T:Ivir\HA1}
Cytology
Description

Encodes a dominant negative form of Iswi (carries the amino acid replacement K159R).

(Deuring et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Iswi
Encoded product / tool
Iswi
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      IswiK159R.Tag:HA fails to rescue Iswi2

      (Arancio et al., 2010)

      IswiK159R.Tag:HA fails to rescue Iswi1

      (Deuring et al., 2000)

      IswiK159R.Tag:HA fails to rescue Iswi2

      (Deuring et al., 2000)
      Comments

      The eye defects seen in flies in which the eyes are homozygous for Iswi2 in an otherwise heterozygous background (generated using the EGUF technique) are not rescued by IswiK159R.T:Ivir\HA1.

      (Arancio et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      IswiK159R.T:Ivir\HA1
      IswiK159R.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)