FlyBase Allele Report: Dmel\Dredd[EP1412]

General Information

Symbol

Dmel\Dredd^EP1412

Species

D. melanogaster

Name

FlyBase ID

FBal0117838

Feature type

allele

Associated gene

Dmel\Dredd

Associated Insertion(s)

P{EP}Dredd^EP1412

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Leulier et al., 2000)

Mutagen

P-element activity

(Di Fruscio et al., 2003, Benos et al., 2001, Gene Disruption Project members, 2001-, Elrod-Erickson et al., 2000, Leulier et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}Dredd^EP1412

Cytology

Description

P{EP} insertion 50bp upstream of the Dredd coding sequence.

(Leulier et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:635,495..635,495 [-]

(Di Fruscio et al., 2003, Benos et al., 2001, Gene Disruption Project members, 2001-, Elrod-Erickson et al., 2000, Leulier et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Sevrioukov et al., 2007, Di Fruscio et al., 2003)

abnormal immune response (with Df(1)su(s)R194)

(Elrod-Erickson et al., 2000)

visible | dominant

(Ayyar et al., 2007)

Phenotype Manifest In

macrochaeta | ectopic

(Ayyar et al., 2007)

mesonotum

(Ayyar et al., 2007)

Detailed Description

Statement

Reference

Heterozygotes show ectopic bristles in 12% of heminota at 18[o]C.

(Ayyar et al., 2007)

Mutant adults are susceptible to infection by E.coli (infection by pricking with a needle dipped in a concentrated pellet of E.coli), showing reduced survival compared to controls.

(Sevrioukov et al., 2007)

Mutant animals have an increased susceptibility to E.coli infection. 30 and 40% of homozygous and heterozygous mutants survive respectively.

(Di Fruscio et al., 2003)

Dredd^EP1412/Df(1)su(s)R194 flies are immunocompromised.

(Elrod-Erickson et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dredd^EP1412 has visible | dominant phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Dredd^EP1412 has visible | dominant phenotype, enhanceable by Tollo¹/Tollo[+]

(Ayyar et al., 2007)

Enhancer of

Statement

Reference

Dredd[+]/Dredd^EP1412 is an enhancer of visible | dominant phenotype of Rel^E20

(Ayyar et al., 2007)

Dredd[+]/Dredd^EP1412 is an enhancer of visible | dominant phenotype of Tollo¹

(Ayyar et al., 2007)

Suppressor of

Statement

Reference

Dredd^EP1412 is a suppressor of short lived phenotype of Mpped^KO

(Gupta et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dredd^EP1412 has macrochaeta | ectopic phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Dredd^EP1412 has mesonotum phenotype, enhanceable by Tollo¹/Tollo[+]

(Ayyar et al., 2007)

Dredd^EP1412 has macrochaeta | ectopic phenotype, enhanceable by Tollo¹/Tollo[+]

(Ayyar et al., 2007)

Dredd^EP1412 has mesonotum phenotype, enhanceable by Rel^E20/Rel[+]

(Ayyar et al., 2007)

Enhancer of

Statement

Reference

Dredd[+]/Dredd^EP1412 is an enhancer of mesonotum phenotype of Rel^E20

(Ayyar et al., 2007)

Dredd[+]/Dredd^EP1412 is an enhancer of macrochaeta | ectopic phenotype of Rel^E20

(Ayyar et al., 2007)

Dredd[+]/Dredd^EP1412 is an enhancer of mesonotum phenotype of Tollo¹

(Ayyar et al., 2007)

Dredd[+]/Dredd^EP1412 is an enhancer of macrochaeta | ectopic phenotype of Tollo¹

(Ayyar et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Dredd^EP1412/+ Tollo¹/+ double heterozygotes show ectopic bristles in 57% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes.

Dredd^EP1412/+ Rel^E20/+ double heterozygotes show ectopic bristles in 58% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes.

(Ayyar et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(1)su(s)R194/Dredd^EP1412 is rescued by Dredd^+tCa

(Elrod-Erickson et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10456

P{EP}Dredd^EP1412 w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dredd^EP1412

(Gupta et al., 2023, Maitra et al., 2019, Ayyar et al., 2007)

EP(1)1412

(Benos et al., 2001)

EP(X)1412

(Stoven et al., 2000)

dredd^EP1412

(Sevrioukov et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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