Allele Dmel\Dredd^EP1412

General Information
Symbol	Dmel\Dredd^EP1412	Species	D. melanogaster
Name		FlyBase ID	FBal0117838
Feature type	allele	Associated gene	Dmel\Dredd

Map ( GBrowse )	Untitled Document
Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Leulier et al., 2000)
Mutagen	P-element activity (Elrod-Erickson et al., 2000, Gene Disruption Project members, 2001-, Leulier et al., 2000, Benos et al., 2001, Di Fruscio et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:529,528..529,528 (Elrod-Erickson et al., 2000, Di Fruscio et al., 2003, Leulier et al., 2000, Gene Disruption Project members, 2001-, Benos et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP} insertion 50bp upstream of the Dredd coding sequence. (Leulier et al., 2000)
Caused by insertion	P{EP}Dredd^EP1412 (Elrod-Erickson et al., 2000, Di Fruscio et al., 2003, Leulier et al., 2000, Gene Disruption Project members, 2001-, Benos et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective (Sevrioukov et al., 2007) immune response defective, with Scer\GAL4[-]: (Di Fruscio et al., 2003) immune response defective (with Df(1)su(s)R194), with Scer\GAL4[-]: (Elrod-Erickson et al., 2000) visible \| dominant (Ayyar et al., 2007)
Phenotype Manifest In
	macrochaeta \| ectopic (Ayyar et al., 2007) mesothoracic tergum (Ayyar et al., 2007)
Detailed Description
	Statement Reference Heterozygotes show ectopic bristles in 12% of heminota at 18[o]C. (Ayyar et al., 2007) Mutant adults are susceptible to infection by E.coli (infection by pricking with a needle dipped in a concentrated pellet of E.coli), showing reduced survival compared to controls. (Sevrioukov et al., 2007) Mutant animals have an increased susceptibility to E.coli infection. 30 and 40% of homozygous and heterozygous mutants survive respectively. (Di Fruscio et al., 2003) Dredd^EP1412/Df(1)su(s)R194 flies are immunocompromised. (Elrod-Erickson et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Dredd^EP1412 has visible \| dominant phenotype, enhanceable by Rel^E20/Rel[+] (Ayyar et al., 2007) Dredd^EP1412 has visible \| dominant phenotype, enhanceable by Tollo¹/Tollo[+] (Ayyar et al., 2007)
Enhancer of
Statement Reference Dredd[+]/Dredd^EP1412 is an enhancer of visible \| dominant phenotype of Rel^E20 (Ayyar et al., 2007) Dredd[+]/Dredd^EP1412 is an enhancer of visible \| dominant phenotype of Tollo¹ (Ayyar et al., 2007)
Phenotype Manifest In
Enhanced by
Statement Reference Dredd^EP1412 has macrochaeta \| ectopic phenotype, enhanceable by Rel^E20/Rel[+] (Ayyar et al., 2007) Dredd^EP1412 has macrochaeta \| ectopic phenotype, enhanceable by Tollo¹/Tollo[+] (Ayyar et al., 2007) Dredd^EP1412 has mesothoracic tergum phenotype, enhanceable by Rel^E20/Rel[+] (Ayyar et al., 2007) Dredd^EP1412 has mesothoracic tergum phenotype, enhanceable by Tollo¹/Tollo[+] (Ayyar et al., 2007)
Enhancer of
Statement Reference Dredd[+]/Dredd^EP1412 is an enhancer of macrochaeta \| ectopic phenotype of Rel^E20 (Ayyar et al., 2007) Dredd[+]/Dredd^EP1412 is an enhancer of macrochaeta \| ectopic phenotype of Tollo¹ (Ayyar et al., 2007) Dredd[+]/Dredd^EP1412 is an enhancer of mesothoracic tergum phenotype of Rel^E20 (Ayyar et al., 2007) Dredd[+]/Dredd^EP1412 is an enhancer of mesothoracic tergum phenotype of Tollo¹ (Ayyar et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Dredd[EP1412]/+ Tollo[1]/+ double heterozygotes show ectopic bristles in 57% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes. Dredd[EP1412]/+ Rel[E20]/+ double heterozygotes show ectopic bristles in 58% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes. (Ayyar et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Df(1)su(s)R194/Dredd^EP1412 is rescued by Scer\GAL4[-]/Dredd^+tCa (Elrod-Erickson et al., 2000)
Comments
Stocks ( 1 )
Bloomington	10456 P{EP}Dredd^EP1412 w¹¹¹⁸
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Dredd^EP1412 (Ayyar et al., 2007) dredd^EP1412 (Sevrioukov et al., 2007) EP(1)1412 (Benos et al., 2001) EP(X)1412 (Stoven et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Ayyar et al., 2007, PLoS ONE 2(11): e1178 NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. [FBrf0210269] Sevrioukov et al., 2007, genesis 45(4): 184--193 Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. [FBrf0202360] Di Fruscio et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(4): 1814--1819 kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms. [FBrf0157185] Benos et al., 2001, Genome Res. 11(5): 710--730 From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823] Elrod-Erickson et al., 2000, Curr. Biol. 10(13): 781--784 Interactions between the cellular and humoral immune responses in Drosophila. [FBrf0128454] Leulier et al., 2000, EMBO Rep. 1(4): 353--358 The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. [FBrf0133276] Stoven et al., 2000, EMBO Rep. 1(4): 347--352 Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage. [FBrf0135745]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\DreddEP1412

Allele Dmel\Dredd^EP1412