Open Close
General Information
Symbol
Dmel\Cdk5UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0117900
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Cdk5, UAS-cdk5-FLAG
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive expression of the Cdk5α cDNA tagged with Tag:FLAG.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Cdk5UAS.Tag:FLAG under the control of Scer\GAL4GMR.PU does not induce neurodegeneration (i.e. brain vacuolization) in 10-days old adults.

Expression of Cdk5Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4GMR.PF has no effect on eye surface morphology. Expression of Cdk5Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4unspecified has no effect on neuron cell fate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
NOT Enhancer of
NOT Suppressor of
Other
Phenotype Manifest In
Enhancer of
NOT Enhancer of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of both Cdk5Scer\UAS.T:Zzzz\FLAG and Cdk5αScer\UAS.cMa under the control of Scer\GAL4GMR.PF results in a mild rough eye phenotype.

When Cdk5αScer\UAS.T:Hsap\MYC and Cdk5Scer\UAS.T:Zzzz\FLAG are driven by Scer\GAL4elav-C155, axon patterning defects are seen. SNa axons are seen lacking the dorsal branch, with ectopic muscle contacts. Overextended and misrouted TN neurons and stalled ISN neurons are also seen. When Cdk5αScer\UAS.T:Hsap\MYC and Cdk5Scer\UAS.T:Zzzz\FLAG are driven by Scer\GAL4GMR.PF, a severely disrupted eye morphology results. In embryos, the proportion seen with nervous system defects increases.

Xenogenetic Interactions
Statement
Reference

Co-expression of Cdk5Scer\UAS.T:Zzzz\FLAG alone does not modify the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF. Co-expression of both Cdk5Scer\UAS.T:Zzzz\FLAG and Cdk5αScer\UAS.cMa together strongly enhances the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Cdk5Scer\UAS.T:Zzzz\FLAG
Cdk5UAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (7)