FB2025_01 , released February 20, 2025
Allele: Dmel\Syt1unspecified
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General Information
Symbol
Dmel\Syt1unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0118047
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Syt1unspecified homozygous mutant larvae show neurotransmission defects at neuromuscular junctions as they fail to support calcium-triggered neurotransmitter release: flat excitatory postsynaptic current trace (recorded in 2 mM external Ca[2+]) with zero amplitude, reduced cumulative vesicle release (defined by charge transfer), high frequency of miniature excitatory junction currents.

        (Herrmann et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Syt1unspecified is rescued by Scer\GAL4elav-C155/Syt1UAS.Tag:MYC

        (Herrmann et al., 2014)

        Syt1unspecified is rescued by Scer\GAL4Toll-6-D42/Syt1UAS.Tag:CALI(4C)

        (Marek and Davis, 2002)
        Partially rescued by

        Syt1unspecified is partially rescued by Syt1elav.PD

        (DiAntonio et al., 1993)
        Not rescued by

        Syt1unspecified is not rescued by Scer\GAL4elav-C155/Syt1D362A.UAS.Tag:MYC

        (Herrmann et al., 2014)
        Comments

        The neurotransmission defects at neuromuscular junctions in (they fail to support calcium-triggered neurotransmitter release: flat excitatory postsynaptic current, recorded in 2 mM external Ca[2+] with zero amplitude, reduced cumulative vesicle release (defined by charge transfer), high frequency of miniature excitatory junction currents) characteristic for Syt1unspecified mutant third instar larvae can be rescued by Scer\GAL4elav-C155-driven expression of Syt1Scer\UAS.T:Hsap\MYC but not Syt1D362A.Scer\UAS.T:Hsap\MYC in the mutant background.

        (Herrmann et al., 2014)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Syt1unspecified
        sytunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)