Allele Dmel\spen^ΔC.Scer\UAS

General Information
Symbol	Dmel\spen^ΔC.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0118051
Feature type	allele	Associated gene	Dmel\spen

Allele class
Mutagen	in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Chen and Rebay, 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A truncated cDNA (removing about 1500 amino acids from the C terminal end) is driven by Scer\UAS sequences. (Chen and Rebay, 2000)
Carried in construct	P{UAS-spen.ΔC} (Chen and Rebay, 2000)
Cytology
Phenotypic Data
Phenotypic Class
	lethal, with Scer\GAL4^sli.PS (Chen and Rebay, 2000) viable, with Scer\GAL4^elav-C155 (Chen and Rebay, 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference Expression of spen^ΔC.Scer\UAS driven by Scer\GAL4^sli.PS leads to completely penetrant lethality. However pan-neural expression of spen^ΔC.Scer\UAS driven by Scer\GAL4^elav-C155 does not compromise the viability or patterning of the fly. (Chen and Rebay, 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^sli.PS, spen^ΔC.Scer\UAS has lethal phenotype, suppressible by Ras85D^V12.Scer\UAS, Scer\GAL4^sli.PS (Chen and Rebay, 2000) Scer\GAL4^sli.PS, spen^ΔC.Scer\UAS has lethal phenotype, suppressible by Scer\GAL4^sli.PS/spi^s.Scer\UAS (Chen and Rebay, 2000)
Suppressor of
Statement Reference spen^ΔC.Scer\UAS, Scer\GAL4^sli.PS is a suppressor of lethal phenotype of Ras85D^V12.Scer\UAS, Scer\GAL4^sli.PS (Chen and Rebay, 2000)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Over 50% of flies expressing both Ras85D^V12.Scer\UAS and spen^ΔC.Scer\UAS under the control of Scer\GAL4^sli.PS are viable and appear to be normally patterned. (Chen and Rebay, 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	spen^ΔC.Scer\UAS
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Chen and Rebay, 2000, Curr. Biol. 10(15): 943--946 split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells. [FBrf0129761]

Allele Dmel\spenΔC.Scer\UAS

Allele Dmel\spen^ΔC.Scer\UAS