Allele Dmel\hiw^ND51

General Information
Symbol	Dmel\hiw^ND51	Species	D. melanogaster
Name		FlyBase ID	FBal0118200
Feature type	allele	Associated gene	Dmel\hiw

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Wan et al., 2000)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation X:14,948,265..14,948,265 comment=The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change. evidence=experimental pr_change=G2037R\|hiw-PA reported_pr_change=G2054R na_change=G14948265A (Wan et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G2054R. (Wan et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| third instar larval stage (Wu et al., 2007)
Phenotype Manifest In
	embryonic/larval neuromuscular junction (Wu et al., 2007, Tian et al., 2011) NMJ bouton (Tian et al., 2011) NMJ bouton \| supernumerary (Wu et al., 2007) synapse (Tian et al., 2011)
Detailed Description
	Statement Reference Homozygous hiw[ND51] mutants exhibit a statistically significant increase in bouton number for muscle 4 synapses compared to controls. (Tian et al., 2011) Mutant larvae show mild synaptic terminal overgrowth at the neuromuscular junction. (Wu et al., 2007)
External Data
Linkouts
Interactions
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Phenotypic Class
Enhanced by
Statement Reference hiw^ND51 has neuroanatomy defective \| third instar larval stage phenotype, enhanceable by Fsn^f06595 (Wu et al., 2007)
Phenotype Manifest In
Enhanced by
Statement Reference hiw^ND51 has embryonic/larval neuromuscular junction phenotype, enhanceable by Fsn^f06595 (Wu et al., 2007) hiw^ND51 has embryonic/larval neuromuscular junction phenotype, enhanceable by Rae1[+]/Rae1^EX28 (Tian et al., 2011) hiw^ND51 has NMJ bouton \| supernumerary phenotype, enhanceable by Fsn^f06595 (Wu et al., 2007) hiw^ND51 has NMJ bouton phenotype, enhanceable by Rae1[+]/Rae1^EX28 (Tian et al., 2011) hiw^ND51 has synapse phenotype, enhanceable by Rae1[+]/Rae1^EX28 (Tian et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference A Rae1[EX28] heterozygous background enhances neuromuscular overgrowth on muscle 4 in hiw[ND51] mutants, with a concomitant statistically significant increase in the number of boutons. (Tian et al., 2011) hiw[ND51] Fsn[f06595] double mutant larvae have dramatically overgrown synapses at the neuromuscular junction, with a significant increase in the number of boutons compared to the hiw[ND51] single mutant and an enhancement of synaptic branching. (Wu et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	hiw^ND51 (Tian et al., 2011, Wu et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Tian et al., 2011, Nat. Neurosci. 14(10): 1267--1275 Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. [FBrf0216253] Wu et al., 2007, Neural Dev. 2: 16 DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth. [FBrf0205388] Wan et al., 2000, Neuron 26(2): 313--329 Highwire regulates synaptic growth in Drosophila. [FBrf0128674]

Allele Dmel\hiwND51

Allele Dmel\hiw^ND51