|Feature type||allele||Associated gene||Dmel\futsch|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Expression of futsch[EP1419] pre-synaptically, under the control of Scer\GAL4[elav-C155] has no significant effect on synaptic mitochondria.
When expression is driven by Scer\GAL4elav-C155 the phenotype is similar to that of Fmr1 loss of function mutants - neuromuscular junction overgrowth with increased synaptic area, branching and bouton number. Neurotransmission at the NMJ is elevated, and in the photoreceptor is depressed.
When expression of futschEP1419 is driven by Scer\GAL4sim.PS, changes in the morphology of individual growth cones is seen, and minor defects in the projection of individual axons are also seen. However these early axonal phenotypes do not lead to defects in the later formation of the central nervous system (CNS) axon pattern.
|Phenotype Manifest In|
futschEP1419, Scer\GAL4elav-C155 is a suppressor of mitochondrion phenotype of Hsap\LRRK2Scer\UAS.T:Zzzz\FLAG, Scer\GAL4elav-C155
futschEP1419, Scer\GAL4elav-C155 is a suppressor of neuromuscular junction phenotype of Hsap\LRRK2Scer\UAS.T:Zzzz\FLAG, Scer\GAL4elav-C155
|NOT Suppressor of|
futschEP1419, Scer\GAL4Mhc.PW is a non-suppressor of neuromuscular junction phenotype of Hsap\LRRK2Scer\UAS.T:Zzzz\FLAG, Scer\GAL4Mhc.PW
Co-expression of futsch[EP1419] pre-synaptically rescues the synaptic overgrowth phenotype found upon expression of Hsap\LRRK2[Scer\UAS.T:Zzzz\FLAG] pre-synaptically under the control of Scer\GAL4[elav-C155]. However, synaptic defects caused by post-synaptic expression of Hsap\LRRK2[Scer\UAS.T:Zzzz\FLAG] are not suppressed when futsch[EP1419] is expressed post-synaptically (under the control of Scer\GAL4[Mhc.PW]). The abnormal microtubule phenotype seen upon Hsap\LRRK2[Scer\UAS.T:Zzzz\FLAG] presynaptic expression is rescued by a futsch[EP1419] expression (both under the control of Scer\GAL4[elav-C155]). Neuronal co-expression of futsch[EP1419] with Hsap\LRRK2[Scer\UAS.T:Zzzz\FLAG] rescues the mitochondrial distribution phenotype seen upon Hsap\LRRK2[Scer\UAS.T:Zzzz\FLAG] expression alone.
Expression of futschEP1419 and Rnor\MAP2Scer\UAS.cAa driven by Scer\GAL444 results in frequent axonal swellings and misprojection phenotypes. In 1/5 of neuromeres sensory neurons project their axons in on one of the two commissures across the central nervous system (CNS) midline and fasciculate with their contralateral counterparts, which they never do in wild-type.
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 7 )|
|Personal communication to FlyBase|