FB2020_06, released Dec 22, 2020

Allele: Dmel\emb2

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General Information
Symbol
Dmel\emb2
Species
D. melanogaster
Name
FlyBase ID
FBal0118251
Feature type
allele
Associated gene
Dmel\emb
Associated Insertion(s)
Carried in Construct
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Collier et al., 2000)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
2L:8,405,522..8,405,522 [+]
Nucleotide change:

T8405522G

Reported nucleotide change:

T?G

Amino acid change:

M412R | emb-PA; M412R | emb-PB

Reported amino acid change:

M413R

(Roth et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: M413R.

      (Roth et al., 2003)

      Nucleotide substitution: T?G.

      (Roth et al., 2003)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous emb2 mutant larvae die at the 2nd instar stage (approximately 70 hours after egg laying).

      (Roth et al., 2003)

      The most advanced stage seen in emb2/Df(2L)N22-14 animals is the 2nd larval instar.

      (Collier et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      emb2 has lethal phenotype, suppressible by mbo1

      (Roth et al., 2003)
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Removal of one copy of mbo1 from emb2 homozygous mutants prolongs the life span of 20% of the individuals to the 3rd instar larval stage (approximately 120 hours after egg laying). This prolonged survival is accompanied by eversion of the anterior spiracles, a morphological characteristic of progression through larval development.

      (Roth et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      emb2
      (Roth et al., 2003)
      l(2)fy4-2
      (Collier et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)