Allele Dmel\crc^R6

General Information
Symbol	Dmel\crc^R6	Species	D. melanogaster
Name		FlyBase ID	FBal0118283
Feature type	allele	Associated gene	Dmel\crc
Also Known As	R6

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Hewes et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	crc⁹²⁹ (Hewes et al., 2000)
Nature of the lesion	Statement Reference Imprecise excision of the P{GawB} element, resulting in a deletion removing crc exons that encode the bZIP domain. This mutation disrupts crc isoforms A and B. Some or all of the P{GawB} element remains. (Hewes et al., 2000)
Caused by insertion	P{?GawB}crc^R6 (Hewes et al., 2000)
Caused by aberration	Df(2L)crc^R6 (Hewes et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Hewes et al., 2000)
Phenotype Manifest In
	adult head (Hewes et al., 2000) anterior pupal spiracle (Hewes et al., 2000) cephalopharyngeal skeleton (with Df(2L)Rev8) (Hewes et al., 2000) pupa (Hewes et al., 2000) ventral thoracic disc (Hewes et al., 2000) wing disc (Hewes et al., 2000)
Detailed Description
	Statement Reference Mutants show several lethal phases during larval, pupal and adult development. Hemizygotes show 15-50% of their lethality after pupariation. Hemizygous puparia are generally aberrant to varying degrees (approximately 5% are indistinguishable from wild type). The defects include a failure to evert the anterior spiracles, and a retention of a larval shape, which is thinned, elongated and sometimes curved to one side. In the most severe cases, the abdominal gas bubble, which normally forms approximately 6 hours after pupariation, does not appear, although the larval mouthparts are later expelled. Head eversion fails or is incomplete and the leg and wing discs do not completely elongate. Third instar crc^R6/Df(2L)Rev8 larvae with multiple mouthparts are seen. crc^R6 shows the "head/abdomen-collapsed" phenotype when heterozygous over some second chromosome balancers, suggesting haploinsufficiency for crc in some genetic backgrounds. (Hewes et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
NOT Suppressor of
Statement Reference crc¹/crc^R6 is a non-suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, ninaE^{G69D.Scer\UAS} (Kang et al., 2012)
Phenotype Manifest In
NOT Suppressor of
Statement Reference crc¹/crc^R6 is a non-suppressor of eye disc phenotype of Scer\GAL4^GMR.PF, ninaE^{G69D.Scer\UAS} (Kang et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference The massive apoptosis seen in the larval eye discs of animals expressing ninaE[G69D.Scer\UAS] under the control of Scer\GAL4[GMR.PF] is not suppressed by crc[R6]/crc[1]. (Kang et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	crc^E85 (Hewes et al., 2000)
Fails to complement	crc¹ (Hewes et al., 2000) crc⁹²⁹ (Hewes et al., 2000) crc^E98 (Hewes et al., 2000) crc^R1 (Hewes et al., 2000) crc^R2 (Hewes et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	crc^R6 (Kang et al., 2012) R6 (Hewes et al., 2003, Hewes et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Kang et al., 2012, Nat. Cell Biol. 14(4): 409--415 CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. [FBrf0217924] Hewes et al., 2003, Development 130(9): 1771--1781 The bHLH protein dimmed controls neuroendocrine cell differentiation in Drosophila. [FBrf0158877] Hewes et al., 2000, Genetics 155(4): 1711--1723 The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. [FBrf0129856]

Allele Dmel\crcR6

Allele Dmel\crc^R6