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General Information
Symbol
Dmel\convk06507b
Species
D. melanogaster
Name
FlyBase ID
FBal0118290
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
convK6507b
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    No mutations have been detected in the conv coding region.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Unlike wild-type, post stage 15 trachea in convk06507b homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.

    Early tracheal development, including primary branch budding and outgrowth and lumen formation and morphology occur normally during stages 11-14. Stage 16 embryos show a number of tracheal defects. These include an increased length of the dorsal trunk compared to wild type (with no accompanying increase in cell number) and mild defects in the diameter of the dorsal trunk and other primary branches. Irregular and variable tracheal tube morphologies, with local constrictions and/or dilations are seen in all major branches. The defects are first seen at stage 15.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The tracheal defects of sinunwu7 mutant embryos are more severe in double mutant combination with convk06507b (severe diameter defects are seen in all multicellular branches and dorsal trunk length appears increased).

    The tracheal phenotypes of nrv2nwu3 homozygotes are exacerbated by convk06507b/convk06507b.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Separable from: P{lacW}sopk06507a. The convk06507b mutation is separable from the sopk06507a mutation caused by the P{lacW}sopk06507a insertion.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (6)
    Reported As
    Symbol Synonym
    convk06507b
    convk6507b
    convl(2)k06507
    conv[k6507b]
    Name Synonyms
    Secondary FlyBase IDs
      References (5)