Allele Dmel\cmet^1x1

General Information
Symbol	Dmel\cmet^1x1	Species	D. melanogaster
Name		FlyBase ID	FBal0118292
Feature type	allele	Associated gene	Dmel\cmet

Allele class
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Yucel et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	cmet⁰⁴⁴³¹ (Yucel et al., 2000)
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	mitotic cell cycle defective \| recessive (Yucel et al., 2000)
Phenotype Manifest In
	centrosome \| germline clone (Yucel et al., 2000) mitosis & nuclear chromosome (Yucel et al., 2000) mitosis & nuclear chromosome \| germ-line clone (Yucel et al., 2000) mitotic anaphase \| germline clone (Yucel et al., 2000) mitotic cell cycle (Yucel et al., 2000) mitotic metaphase \| germline clone (Yucel et al., 2000)
Detailed Description
	Statement Reference The fraction of mitotic cells in larval brain squashes is increased compared to wild type. There is an increase in the number of prometaphase/metaphase figures. The mitotic cells frequently contain misaligned chromosomes. Chromosomes sometimes appear to be undercondensed. The chromosomes are much less tightly associated with the metaphase plate than in wild-type cells. Many mitotic nuclei have chromosomes that are not correctly aligned on the metaphase plate in embryos derived from homozygous female germline clones. Centrosomes that are no longer associated with nuclei are seen. Numerous polyploid nuclei are present. These defects are seen as early as the 8th embryonic mitosis and become more prominent during later cell cycles. Anaphase defects, such as unequal anaphases lacking centrosomes are also observed in less than 10% of mitoses. Chromosome congression appears to proceed relatively normally in these embryos, but the chromosomes do not stably persist at the metaphase plate. Sporadically, they move off the plate before anaphase onset. Anaphase takes place on schedule, and occurs simultaneously for both aligned and misaligned chromosomes. In no case is premature sister chromatid separation of aligned or misaligned chromosomes seen, and the duration of anaphase is not significantly extended. (Yucel et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Complements: ab^unspecified. (Yucel et al., 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cmet^1x1
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Yucel et al., 2000, J. Cell Biol. 150(1): 1--11 CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. [FBrf0128693]

Allele Dmel\cmet1x1

Allele Dmel\cmet^1x1