Allele Dmel\cmet^Δ

General Information
Symbol	Dmel\cmet^Δ	Species	D. melanogaster
Name		FlyBase ID	FBal0118293
Feature type	allele	Associated gene	Dmel\cmet

Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Williams et al., 2003)
Mutagen	Delta2-3 (Yucel et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	cmet⁰⁴⁴³¹ (Yucel et al., 2000)
Nature of the lesion	Statement Reference Imprecise excision of the P{PZ} element deleting approximately 5kb of genomic DNA just upstream of the 5' end of the initial P{PZ} element insertion site. (Yucel et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	mitotic cell cycle defective (Williams et al., 2003) mitotic cell cycle defective \| recessive (Yucel et al., 2000)
Phenotype Manifest In
	condensed nuclear chromosome (Williams et al., 2003) mitosis & nuclear chromosome (Yucel et al., 2000) mitosis & nuclear chromosome \| germ-line clone (Yucel et al., 2000) mitotic anaphase \| germline clone (Yucel et al., 2000) mitotic cell cycle (Yucel et al., 2000) mitotic metaphase \| germline clone (Yucel et al., 2000) spermatocyte (Wainman et al., 2009)
Detailed Description
	Statement Reference Mutant spermatocytes form meiotic spindles with centrosomes at the poles that are indistinguishable from wild-type spindles. Homozygous spermatocytes often show unequal DNA segregation in meiosis I. (Wainman et al., 2009) The brains of homozygous cmet^Δ larvae contain aneuploid cells and precocious sister chromatid separation. (Williams et al., 2003) The fraction of mitotic cells in larval brain squashes is increased compared to wild type. There is an increase in the number of prometaphase/metaphase figures. The mitotic cells frequently contain misaligned chromosomes. Chromosomes sometimes appear to be undercondensed. Embryos derived from homozygous female germline clones are produced at low frequencies. 20% of the embryos show defects, such as an unusual overall shape, that are strongly suggestive of abnormal oogenesis. In the few embryos obtained, prominent chromosome alignment defects are seen and well as many nuclei with abnormally high chromosome content. Maintenance of chromosome congression is clearly aberrant; tight metaphase alignment of most chromosomes is not maintained and the misaligned chromosomes may stay misaligned through initiation of anaphase. Both sister chromatids may migrate to the same pole. Anaphase duration is not detectably extended. (Yucel et al., 2000)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	32327 y¹ w^*; cmet^Δ/CyO, y⁺
Notes on Origin
Discoverer

Comments
	Complements: ab^unspecified. (Yucel et al., 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cmet^Δ (Wainman et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Wainman et al., 2009, J. Cell Sci. 122(11): 1747--1758 Roles of the Drosophila NudE protein in kinetochore function and centrosome migration. [FBrf0207980] Williams et al., 2003, Mol. Biol. Cell 14(4): 1379--1391 Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. [FBrf0159187] Yucel et al., 2000, J. Cell Biol. 150(1): 1--11 CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. [FBrf0128693]

Allele Dmel\cmetΔ

Allele Dmel\cmet^Δ