|Feature type||allele||Associated gene||Dmel\cmet|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
mitosis & nuclear chromosome
mitosis & nuclear chromosome | germ-line clone
Mutant spermatocytes form meiotic spindles with centrosomes at the poles that are indistinguishable from wild-type spindles. Homozygous spermatocytes often show unequal DNA segregation in meiosis I.
The brains of homozygous cmetΔ larvae contain aneuploid cells and precocious sister chromatid separation.
The fraction of mitotic cells in larval brain squashes is increased compared to wild type. There is an increase in the number of prometaphase/metaphase figures. The mitotic cells frequently contain misaligned chromosomes. Chromosomes sometimes appear to be undercondensed. Embryos derived from homozygous female germline clones are produced at low frequencies. 20% of the embryos show defects, such as an unusual overall shape, that are strongly suggestive of abnormal oogenesis. In the few embryos obtained, prominent chromosome alignment defects are seen and well as many nuclei with abnormally high chromosome content. Maintenance of chromosome congression is clearly aberrant; tight metaphase alignment of most chromosomes is not maintained and the misaligned chromosomes may stay misaligned through initiation of anaphase. Both sister chromatids may migrate to the same pole. Anaphase duration is not detectably extended.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 3 )|