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General Information
Symbol
Dmel\capt10
Species
D. melanogaster
Name
FlyBase ID
FBal0118306
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In

    follicle cell & actin filament | ectopic | somatic clone

    follicle cell & actin filament | somatic clone

    oocyte & actin filament | ectopic | germ-line clone

    Detailed Description
    Statement
    Reference

    Heterozygotes do not show midline crossing errors in the central nervous system.

    Mutant follicle cell clones have profound defects in their actin cytoarchitecture; ectopic F-actin accumulates at the apical surface of the cells, close to the germline, while actin filaments at the lateral and basal cortices usually remain unaffected, although F-actin is occasionally lost from the basal surface. In early egg chambers, ectopic actin filaments are first seen accumulating at sites of cell-cell contact.

    Ectopic actin filaments first form at the posterior of the oocyte at stage 5-6 in capt10 germ-line clones.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    capt10/capt[+] is an enhancer of abnormal neuroanatomy phenotype of sli2

    NOT Enhancer of
    Statement
    Reference

    capt10/capt[+] is a non-enhancer of abnormal neuroanatomy | recessive phenotype of robo3[+]/robo31, robo11

    Other
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    capt10 chb4 double heterozygous embryos do not show a significant increase in axons ectopically crossing the midline compared to controls. capt10 chbP4 double heterozygous embryos do not show a significant increase in axons ectopically crossing the midline compared to controls.

    Central nervous system axons are seen to cross the midline in Abl4 capt10 double heterozygous embryos. Central nervous system axons are seen to cross the midline in Abl2 capt10 double heterozygous embryos. Src64BPI capt10 double heterozygotes do not show significant midline crossing defects in the embryonic central nervous system. The frequency of ectopic crossing of the midline by axons in the central nervous system seen in sli2 heterozygous embryos is increased if they are also heterozygous for capt10. capt10 learobo2-4 double heterozygotes show little if any midline crossing defects in the embryonic central nervous system. capt10 robo31 double heterozygotes show little if any midline crossing defects in the embryonic central nervous system. One copy of capt10 does not enhance the frequency of midline crossing defects seen in robo1 robo31 double mutant heterozygotes. capt10/Df(2L)ast2 embryos show 54% ectopic midline crossing by axons in the central nervous system.

    Ectopic actin filaments do not form in capt10 chic05205a double mutant follicle cell clones, and the level of F-actin in these cells appears to be similar to that in chic05205a single mutant cells. Cells in capt10 chic05205a double mutant follicle cell clones lose their columnar morphology and collapse, forming a thin squamous-like layer of cells. These clones can interfere with the migration of wild-type portions of the follicle cell epithelium. The double mutant clones maintain extensive contacts with adjacent wild-type cells. F-actin is often seen accumulating at a single, randomly positioned site within the cell in capt10 l(2)gl4 double mutant follicle cell clones. Ectopic actin filaments do not form in enaunspecified capt10 double mutant follicle cell clones and F-actin levels are often decreased. Expression of AblScer\UAS.cFa under the control of Scer\GAL4T155 in capt10 mosaic egg chambers alters both the level and distribution of actin filaments in the capt10 mutant cells. In a few egg chambers, the epithelial morphology is profoundly disrupted.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (5)