FlyBase Allele Report: Scer\GAL4[12.1]

In late embryos, expression is observed in all sensory neurons (groups numbered 1-9 in FBrf0064796), with expression completely restricted to the PNS; see reference for detailed description.

(Suster and Bate, 2002)

In late embryos, reporter protein is also localized to dendritic processes and axon terminals of sensory neurons.

(Hummel et al., 2000)

Marker for

larval peripheral nervous system

(Suster and Bate, 2002)

sensory mother cell

(Wolf and Schuh, 2000)

sensory neuron

(Parsons et al., 2003, Hummel et al., 2000)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | embryonic stage, with Ctet\tetX^TNT-LC.UAS

(Suster and Bate, 2002)

abnormal behavior | larval stage, with Ctet\tetX^TNT-LC.UAS

(Suster and Bate, 2002)

abnormal locomotor behavior | larval stage | heat sensitive, with shi^1.UAS

(Iyengar et al., 2011)

abnormal neurophysiology, with Ctet\tetX^TNT-LC.UAS

(Suster and Bate, 2002)

abnormal pain response, with Hsap\RAB7A^{L129F.UAS.N.GFP}

(Janssens et al., 2014)

abnormal temperature response, with Hsap\RAB7A^{L129F.UAS.N.GFP}

(Janssens et al., 2014)

abnormal touch response | larval stage | heat sensitive, with shi^1.UAS

(Iyengar et al., 2011)

decreased rate of movement | larval stage | heat sensitive, with shi^1.UAS

(Iyengar et al., 2011)

long lived, with gig^UAS.cTa

(Kapahi et al., 2004)

long lived | heat sensitive, with GLaz^EP2383

(Walker et al., 2006)

long lived | heat sensitive, with GLaz^UAS.cWa

(Walker et al., 2006)

Phenotype Manifest In

abdominal basiconical sensillum dbd & embryo & nerve terminal, with robo3^UAS.cSa

(Zlatic et al., 2003)

chordotonal organ & embryo & nerve terminal, with comm^UAS.cKa

(Zlatic et al., 2003)

embryonic/larval hypodermal muscle cell | heat sensitive, with shi^1.UAS

(Iyengar et al., 2011)

embryonic/larval tracheal dorsal trunk, with hb^UAS.cWa

(Wolf and Schuh, 2000)

intermediate longitudinal fascicle, with robo3¹, robo3^UAS.cSa

(Zlatic et al., 2003)

medial longitudinal fascicle, with robo3¹, robo3^UAS.cSa

(Zlatic et al., 2003)

presumptive embryonic/larval peripheral nervous system, with Ctet\tetX^TNT-LC.UAS

(Suster and Bate, 2002)

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 31-32[o]C) of Scer\GAL4^12.1 cells in third instar larvae results in locomotor defects, including significantly reduced peristaltic contraction frequency during slow, but not fast, locomotion and more circular path trajectories, compared to controls, there is also a significant reduction in head swings in response to nose-touch stimuli, compared to controls.

(Iyengar et al., 2011)

External Data

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Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions