Allele Dmel\Mad^unspecified

General Information
Symbol	Dmel\Mad^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0118422
Feature type	allele	Associated gene	Dmel\Mad

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (McCabe et al., 2004)
Phenotype Manifest In
	synapse (McCabe et al., 2004) t-bar (McCabe et al., 2004)
Detailed Description
	Statement Reference The number of T bars per active zone and bouton surface area per active zone is increased compared to wild type in the boutons of muscle 6/7 in mutant third instar larvae. 37 +/- 4% detachment of the presynaptic membrane is seen. (McCabe et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference Mad^unspecified is a non-enhancer of visible phenotype of W^GMR.PG/W^GMR.PG (Bach et al., 2003)
NOT Suppressor of
Statement Reference Mad^unspecified is a non-suppressor of visible phenotype of W^GMR.PG/W^GMR.PG (Bach et al., 2003)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Mad^unspecified is a non-enhancer of eye phenotype of W^GMR.PG/W^GMR.PG (Bach et al., 2003)
Suppressor of
Statement Reference dpp^d-ho/Mad^unspecified is a suppressor of phenotype of CycE^JP (Horsfield et al., 1998) Mad[+]/Mad^unspecified is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^ey.PH, dally^Scer\UAS.cJa (Kirkpatrick et al., 2006)
NOT Suppressor of
Statement Reference Mad[+]/Mad^unspecified is a non-suppressor of wing vein \| ectopic phenotype of Egfr^E1 (Li and Li, 2003) Mad^unspecified is a non-suppressor of eye phenotype of W^GMR.PG/W^GMR.PG (Bach et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The reduction in the number of photoreceptors per ommatidia seen in eyes that express dally^Scer\UAS.cJa under the control of Scer\GAL4^ey.PH is suppressed in a Mad^unspecified/+ mutant background. (Kirkpatrick et al., 2006) The eye phenotype caused by expression of tkv^{Q253D.Scer\UAS.cLa} under the control of Scer\GAL4^GMR.PF is partially modified by Mad^unspecified. (Bach et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Mad^k00237 (Dworkin and Gibson, 2006) Mad^KG00581 (Dworkin and Gibson, 2006)
Rescued by	Mad^unspecified is rescued by Mad^+t11.5 (Sekelsky et al., 1995) Mad^unspecified is rescued by Mad^{Ubi-p63E.T:Hsap\MYC} (Sekelsky et al., 1995)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Mad^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Anderson et al., 2006, Dev. Biol. 297(2): 536--549 Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. [FBrf0193889] Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Kirkpatrick et al., 2006, Dev. Biol. 300(2): 570--582 The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. [FBrf0194660] McCabe et al., 2004, Neuron 41(6): 891--905 Highwire regulates presynaptic BMP signaling essential for synaptic growth. [FBrf0175022] Bach et al., 2003, Genetics 165(3): 1149--1166 A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. [FBrf0167623] Li and Li, 2003, Genetics 164(1): 247--258 Drosophila gain-of-function mutant RTK Torso triggers ectopic Dpp and STAT signaling. [FBrf0158996] Horsfield et al., 1998, Development 125(24): 5069--5078 decapentaplegic is required for arrest in G1 phase during Drosophila eye development. [FBrf0105843] Sekelsky et al., 1995, Genetics 139(3): 1347--1358 Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. [FBrf0080380]

Allele Dmel\Madunspecified

Allele Dmel\Mad^unspecified