FlyBase Allele Report: Dmel\Nup44A[EP2417]

General Information

Symbol

Dmel\Nup44A^EP2417

Species

D. melanogaster

Name

FlyBase ID

FBal0119166

Feature type

allele

Associated gene

Dmel\Nup44A

Associated Insertion(s)

P{EP}Nup44A^EP2417

Carried in Construct

Also Known As

EP(2)2417

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bidet et al., 2003, Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}Nup44A^EP2417

Cytology

Description

P{EP} insertion 456bp upstream of the Nup44A translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of Nup44A.

(Bidet et al., 2003)

The P{EP} insertion is 257bp upstream of the putative ATG start codon in the same orientation to the transcription unit.

(Fernandez-Funez et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:7,989,699..7,989,699 [+]

(Anderson et al., 2021, Senger et al., 2011, Branco et al., 2008, Ghosh and Feany, 2004, Bidet et al., 2003, Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Phenotype Manifest In

eye, with Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Detailed Description

Statement

Reference

Expression of Nup44A^EP2417 under the control of Scer\GAL4^Cha.7.4 results in a rough eye phenotype.

(Ghosh and Feany, 2004)

Expression of Nup44A^EP2417 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Nup44A^EP2417, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

Nup44A^EP2417, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Nup44A^EP2417, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Nup44A[+]/Nup44A^EP2417 is a suppressor | partially of egg chamber phenotype of mio²/mio¹

(Senger et al., 2011)

Nup44A^EP2417, Scer\GAL4^GMR.PU is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Nup44A^EP2417, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Nup44A^EP2417, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Suppressor of

Statement

Reference

Nup44A^EP2417, Scer\GAL4^GMR.PU is a non-suppressor of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Nup44A^EP2417, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Nup44A^EP2417/+ partially suppresses the mio¹/mio² oogenesis phenotype. In contrast to mio¹/mio² single mutants, egg chambers from Nup44A^EP2417/+, mio¹/mio² females frequently progress through vitellogenesis to produce mature eggs. Moreover, a small percentage of the eggs laid by Nup44A^EP2417/+, mio¹/mio² females hatch and develop into viable adults.

(Senger et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of Nup44A^EP2417 does not suppress the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Nup44A^EP2417 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Nup44A^EP2417.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17053

w¹¹¹⁸; P{EP}Nup44A^EP2417

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(2)2417

(Shulman and Feany, 2003)

Nup44A^EP2417

(Anderson et al., 2021)

nup44A^EP2417

(Fernandez-Funez et al., 2000)

seh1^EP2417

(Senger et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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