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General Information
Symbol
Dmel\Nup44AEP2417
Species
D. melanogaster
Name
FlyBase ID
FBal0119166
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(2)2417
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion 456bp upstream of the Nup44A translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of Nup44A.

The P{EP} insertion is 257bp upstream of the putative ATG start codon in the same orientation to the transcription unit.

Insertion components
P{EP}Nup44AEP2417
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Nup44AEP2417 under the control of Scer\GAL4Cha.7.4 results in a rough eye phenotype.

Expression of Nup44AEP2417 under the control of Scer\GAL4GMR.PF does not result in a rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Nup44AEP2417/+ partially suppresses the mio1/mio2 oogenesis phenotype. In contrast to mio1/mio2 single mutants, egg chambers from Nup44AEP2417/+, mio1/mio2 females frequently progress through vitellogenesis to produce mature eggs. Moreover, a small percentage of the eggs laid by Nup44AEP2417/+, mio1/mio2 females hatch and develop into viable adults.

Xenogenetic Interactions
Statement
Reference

Expression of Nup44AEP2417 does not suppress the retinal phenotype seen when Hsap\HTT128Q.1-336.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

Expression of Nup44AEP2417 suppresses the retinal phenotype seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is not modified if the flies are also carrying Nup44AEP2417.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Nup44AEP2417
Name Synonyms
Secondary FlyBase IDs
    References (7)