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General Information
Symbol
Dmel\grimGMR.PH
Species
D. melanogaster
Name
glass multimer reporter construct of Hawkins
FlyBase ID
FBal0119243
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-Grim
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of grim.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eyes are highly ablated and abnormally shaped.

Flies expressing grimGMR.PH have smaller eyes than normal.

Flies that express grimGMR.PH have small eyes.

Flies expressing grimGMR.PH have a small eye phenotype.

Expression of grimGMR.PH results in a small eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

grimGMR.PH has visible phenotype, non-enhanceable by ecSF1.GMR

grimGMR.PH has visible phenotype, non-enhanceable by ecEPΔ4

Suppressed by
NOT suppressed by
Statement
Reference

grimGMR.PH has visible phenotype, non-suppressible by ecEPΔ4

grimGMR.PH has visible phenotype, non-suppressible by ecSF1.GMR

grimGMR.PH has visible phenotype, non-suppressible by PsnC1/Psn[+]

grimGMR.PH has visible phenotype, non-suppressible by PsnD278A.GMR

grimGMR.PH has visible phenotype, non-suppressible by nct[+]/NctJ2

grimGMR.PH has visible phenotype, non-suppressible by Df(2L)1567/+

grimGMR.PH has increased cell death phenotype, non-suppressible by Scer\GAL4[-]/jumuEP739

grimGMR.PH has increased cell death phenotype, non-suppressible by P{EP}stich1EP359/Scer\GAL4[-]

Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference

grimGMR.PH has eye phenotype, non-enhanceable by ecSF1.GMR

grimGMR.PH has eye phenotype, non-enhanceable by ecEPΔ4

grimGMR.PH has eye phenotype, non-enhanceable by BruceBIR.GMR

Suppressed by
Statement
Reference

grimGMR.PH has eye phenotype, suppressible | partially by scnyD.GMR

grimGMR.PH has eye phenotype, suppressible by DriceΔ1/DriceΔ1

grimGMR.PH has eye phenotype, suppressible | partially by Dronc11/Nc[+]

grimGMR.PH has eye phenotype, suppressible | partially by Dronc51/Nc[+]

grimGMR.PH has eye phenotype, suppressible | partially by Dronc30/Nc[+]

grimGMR.PH has eye phenotype, suppressible by mir-14GMR.PX

grimGMR.PH has eye phenotype, suppressible by BruceGMREP-86a-2

grimGMR.PH has eye phenotype, suppressible by BruceGMREP-86a-3

grimGMR.PH has eye phenotype, suppressible by BruceGMREP-86a-4

grimGMR.PH has eye phenotype, suppressible by BruceGMREP-86a-5

grimGMR.PH has eye phenotype, suppressible by BruceGMREP-86a-1

grimGMR.PH has eye phenotype, suppressible by DroncC318S.GMR

NOT suppressed by
Statement
Reference

grimGMR.PH has eye phenotype, non-suppressible by ecEPΔ4

grimGMR.PH has eye phenotype, non-suppressible by ecSF1.GMR

grimGMR.PH has eye phenotype, non-suppressible by PsnC1/Psn[+]

grimGMR.PH has eye phenotype, non-suppressible by PsnD278A.GMR

grimGMR.PH has eye phenotype, non-suppressible by nct[+]/NctJ2

grimGMR.PH has eye phenotype, non-suppressible by Df(2L)1567/+

grimGMR.PH has eye phenotype, non-suppressible by jumu06439

grimGMR.PH has eye phenotype, non-suppressible by Scer\GAL4[-]/jumuEP739

grimGMR.PH has eye phenotype, non-suppressible by l(3)j8B6j8B6

grimGMR.PH has eye phenotype, non-suppressible by BruceBIR.GMR

grimGMR.PH has eye phenotype, non-suppressible by P{EP}stich1EP359/Scer\GAL4[-]

grimGMR.PH has eye phenotype, non-suppressible by jumu06142a

Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4GMR.PF-mediated expression of P{Sym-UAS-Hsrω} significantly rescues the grimGMR.PH eye phenotype.

Scer\GAL4GMR.PF-mediated expression of HsrωEP3037 significantly enhances the grimGMR.PH eye phenotype.

Scer\GAL4GMR.PF-mediated expression of P{Sym-UAS-Hsrω} eliminates the enhancing effect of HsrωEP3037 on grimGMR.PH eyes as well as reversing the level of degeneration seen in eyes expressing grimGMR.PH alone.

Expression of thdsRNA.Scer\UAS.cLa using Scer\GAL4GMR.PF enhances the grimGMR.PH small eye phenotype.

Co-expression of P{Sym-UAS-Hsrω} fails to suppress the eye damage in the grimGMR.PH, thdsRNA.Scer\UAS.cLa, Scer\GAL4GMR.PF background.

The small eye phenotype exhibited by flies expressing grimGMR.PH is suppressed in a IceΔ1 homozygous background.

The rough, small eye phenotype of grimGMR.PH is partially suppressed by Nc11/+, Nc51/+ or Nc30/+.

PsnC1/+ or NctJ2/+ does not suppress the small eye phenotype caused by expression of grimGMR.PH.

PsnD278A.GMR does not suppress the small eye phenotype caused by expression of grimGMR.PH.

Expression of NctdsRNA.291-696.GMR does not suppress the small eye phenotype caused by expression of grimGMR.PH.

Expression of aph-1dsRNA.29-174.GMR does not suppress the small eye phenotype caused by expression of grimGMR.PH.

When one of BruceGMREP-86a-1, BruceGMREP-86a-2, BruceGMREP-86a-3, BruceGMREP-86a-4 or BruceGMREP-86a-5 is added to grimGMR.PH, its cell death phenotype in the eye is suppressed. The addition of jumuEP739, jumu06142a, jumu06439, l(3)j8B6j8B6 or P{EP}stich1EP359 has no effect. The addition of BruceE16 or BruceE12 enhances the cell death phenotype in the eye seen in grimGMR.PH animals alone. The addition of BruceBIR.GMR has no effect on the cell death phenotype in the eye seen in grimGMR.PH animals alone.

Co-expression of NcC318S.GMR suppresses the grimGMR.PH small eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
grimGMR.PH
Name Synonyms
glass multimer reporter construct of Hawkins
Secondary FlyBase IDs
    References (12)