Allele Dmel\dco^ar

General Information
Symbol	Dmel\dco^ar	Species	D. melanogaster
Name		FlyBase ID	FBal0119276
Feature type	allele	Associated gene	Dmel\dco
Also Known As	dbt^ar

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Yu et al., 2006)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:26,883,198..26,883,198 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C26883198T pr_change=H126Y\|dco-PB,H126Y\|dco-PC,H126Y\|dco-PA reported_pr_change=H126Y (Rothenfluh et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: H126Y. (Rothenfluh et al., 2000)
Cytology
Phenotypic Data
Phenotypic Class
	cell polarity defective (with dco^j3B9) (Klein et al., 2006) circadian rhythm defective (Rothenfluh et al., 2000) circadian rhythm defective (with dco^j3B9) (Rothenfluh et al., 2000) circadian rhythm defective (with Df(3R)tll-g) (Rothenfluh et al., 2000) circadian rhythm defective \| semidominant (Rothenfluh et al., 2000) locomotor rhythm defective (with dco^VIII) (Sekine et al., 2008) locomotor rhythm defective \| semidominant (Rothenfluh et al., 2000) partially lethal - majority live \| recessive (Rothenfluh et al., 2000) viable (with dco^j3B9) (Yu et al., 2006) viable (with dco^VIII) (Sekine et al., 2008)
Phenotype Manifest In
	ommatidium (with dco^j3B9) (Klein et al., 2006)
Detailed Description
	Statement Reference Approximately 50% of dco[ar]/dco[VIII] flies display locomotor arrhythmicity. (Sekine et al., 2008) The eyes of dco^j3B9/dco^ar transheterozygotes show mild planar cell polarity defects. (Klein et al., 2006) Unlike other dco mutant flies, dco^ar homozygotes show an arrhythmic circadian locomotor activity. About 70% of homozygotes are viable. Heterozygotes show a strong semidominant period-lengthening, about 7% of flies are arrhythmic. About 2/3 of dco^ar/dco^j3B9 flies are arrhythmic, the rest show a period-lengthening phenotype. Over 4/5 of dco^ar/Df(3R)tll-g flies are arrhythmic, the rest show a period-lengthening phenotype. (Rothenfluh et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference dco^j3B9/dco^ar has circadian rhythm defective phenotype, suppressible \| partially by per^s (Rothenfluh et al., 2000) dco^j3B9/dco^ar has circadian rhythm defective phenotype, suppressible \| partially by per^T (Rothenfluh et al., 2000) Df(3R)tll-g/dco^ar has circadian rhythm defective phenotype, suppressible \| partially by per^T (Rothenfluh et al., 2000)
NOT suppressed by
Statement Reference dco^j3B9/dco^ar has circadian rhythm defective phenotype, non-suppressible by per^SLIH (Rothenfluh et al., 2000) dco^j3B9/dco^ar has circadian rhythm defective phenotype, non-suppressible by tim^S1/tim⁰¹ (Rothenfluh et al., 2000) dco^VIII/dco^ar has locomotor rhythm defective phenotype, non-suppressible by Scer\GAL4^arm.PS/dco::Hsap\CSNK1E^Scer\UAS.cSa (Sekine et al., 2008) dco^VIII/dco^ar has locomotor rhythm defective phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\CSNK1E^Scer\UAS.cSa (Sekine et al., 2008) Df(3R)tll-g/dco^ar has circadian rhythm defective phenotype, non-suppressible by per^SLIH (Rothenfluh et al., 2000) Df(3R)tll-g/dco^ar has circadian rhythm defective phenotype, non-suppressible by tim[+]/tim⁰¹ (Rothenfluh et al., 2000) Df(3R)tll-g/dco^ar has circadian rhythm defective phenotype, non-suppressible by tim^S1/tim⁰¹ (Rothenfluh et al., 2000)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference The addition of per^s or per^T to dco^j3B9/dco^ar or Df(3R)tll-g/dco^ar flies suppresses the arrhythmicity phenotype seen in these flies. The addition of tim^S1/tim⁰¹, tim⁰¹/+, or per^SLIH does not suppress the dco^ar/dco^j3B9 and dco^ar/Df(3R)tll-g arrhythmic phenotypes. (Rothenfluh et al., 2000)
Xenogenetic Interactions
Statement Reference Expression of Hsap\CSNK1E[Scer\UAS.cSa] under the control of Scer\GAL4[arm.PS] fails to rescue the locomotor rhythm defects seen in dco[ar]/dco[VIII]. (Sekine et al., 2008)
Complementation & Rescue Data
Fails to complement	dco^j3B9 (Rothenfluh et al., 2000)
Rescued by	dco^VIII/dco^ar is rescued by Scer\GAL4^arm.PS/dco^Scer\UAS.cSa (Sekine et al., 2008)
Comments	Expression of dco[Scer\UAS.cSa] under the control of Scer\GAL4[arm.PS] rescues the locomotor rhythm defects seen in dco[VIII]/dco[ar]. (Sekine et al., 2008)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dbt^ar (Kim and Edery, 2006, Weber and Kay, 2003, Stanewsky, 2002, Stanewsky, 2003, Rothenfluh et al., 2000, Yu et al., 2006, Cyran et al., 2005, Sekine et al., 2008) dbt^AR (Klein et al., 2006, Kivimäe et al., 2008) dco^ar
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Kivimäe et al., 2008, PLoS Biol. 6(7): e183 Activating PER repressor through a DBT-directed phosphorylation switch. [FBrf0205742] Sekine et al., 2008, J. Biol. Rhythms 23(1): 3--15 Casein kinase Iε does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock. [FBrf0202894] Kim and Edery, 2006, Proc. Natl. Acad. Sci. U.S.A. 103(16): 6178--6183 Balance between DBT/CKI epsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. [FBrf0191446] Klein et al., 2006, Curr. Biol. 16(13): 1337--1343 CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. [FBrf0191849] Yu et al., 2006, Genes Dev. 20(6): 723--733 PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. [FBrf0190570] Cyran et al., 2005, J. Neurosci. 25(22): 5430--5437 The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. [FBrf0187899] Weber and Kay, 2003, FEBS Lett. 555(2): 341--345 A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. [FBrf0167584] Rothenfluh et al., 2000, Curr. Biol. 10(21): 1399--1402 Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. [FBrf0131392]
Review	Stanewsky, 2003, J. Neurobiol. 54(1): 111--147 Genetic analysis of the circadian system in Drosophila melanogaster and mammals. [FBrf0155881] Stanewsky, 2002, Cell Tissue Res. 309(1): 11--26 Clock mechanisms in Drosophila. [FBrf0151232]

Allele Dmel\dcoar

Allele Dmel\dco^ar