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General Information
Symbol
Dmel\dcoar
Species
D. melanogaster
Name
FlyBase ID
FBal0119276
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dbtar
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C31057476T

    Amino acid change:

    H126Y | dco-PA; H126Y | dco-PB; H126Y | dco-PC; H126Y | dco-PD; H126Y | dco-PE

    Reported amino acid change:

    H126Y

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: H126Y.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    dcoar/+ flies have a lengthened circadian period.

    In constant darkness, dcoar/+ heterozygotes display a slightly longer period compared to wild type flies. Almost half of dcoEY02910/dcoar flies are arrhythmic, while most of the remainder show weak rhythms and a longer period.

    Approximately 50% of dcoar/dcoVIII flies display locomotor arrhythmicity.

    The eyes of dcoj3B9/dcoar transheterozygotes show mild planar cell polarity defects.

    Unlike other dco mutant flies, dcoar homozygotes show an arrhythmic circadian locomotor activity. About 70% of homozygotes are viable. Heterozygotes show a strong semidominant period-lengthening, about 7% of flies are arrhythmic. About 2/3 of dcoar/dcoj3B9 flies are arrhythmic, the rest show a period-lengthening phenotype. Over 4/5 of dcoar/Df(3R)tll-g flies are arrhythmic, the rest show a period-lengthening phenotype.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Adult-specific expression (using TubGAL80ts) of larkScer\UAS.T:Ivir\HA1 driven by Scer\GAL4P2.4.Pdf significantly lengthens circadian period in dcoar/+ flies; co-expression of larkdsRNA.Scer\UAS.cSb significantly shortens circadian period.

    The addition of pers or perT to dcoj3B9/dcoar or Df(3R)tll-g/dcoar flies suppresses the arrhythmicity phenotype seen in these flies. The addition of timS1/tim01, tim01/+, or perSLIH does not suppress the dcoar/dcoj3B9 and dcoar/Df(3R)tll-g arrhythmic phenotypes.

    Xenogenetic Interactions
    Statement
    Reference

    Expression of Hsap\CSNK1EScer\UAS.cSa under the control of Scer\GAL4arm.PS fails to rescue the locomotor rhythm defects seen in dcoar/dcoVIII.

    Complementation and Rescue Data
    Fails to complement
    Comments

    Expression of dcoScer\UAS.cSa under the control of Scer\GAL4arm.PS rescues the locomotor rhythm defects seen in dcoVIII/dcoar.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    References (14)