FlyBase Allele Report: Dmel\bsk[K53R.UAS]

Expressing bsk^K53R.UAS under the control of Scer\GAL4^tey-5053A (together with Dicer-2, for efficient RNAI) provides significant protection against (injury-induced) Wallerian degeneration of third instar larval motoneurons.

(Hao et al., 2019)

Expressing bsk^K53R.UAS under the control of Scer\GAL4^C587 (together with Dicer-2, for a more efficient RNAi) does not induce any obvious L3 spermatogenesis defects.

(La Marca et al., 2019)

The expression of bsk^K53R.UAS under the control of Scer\GAL4^hh-Gal4 does not lead to any obvious phenotype in the wing disc, as compared to controls.

(de Vreede et al., 2018)

The expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 does not result in any obvious size or viability defects in third instar larval wing discs, as compared to controls.

(Bunker et al., 2015)

The expression of bsk^{K53R.Scer\UAS} in third instar larval wing discs does not result in any obvious cell migration defects (when expression is driven by Scer\GAL4^dpp.PU) and does not lead to any obvious signs of basal delamination, such as embedment in the extracellular matrix or extrusion from the epithelium (when expression is driven by Scer\GAL4^C-765), as compared to controls.

(Shen et al., 2014)

The temporally regulated expression (by Gal80[ts]) of bsk^K53R.UAS for 6 days under the control of Scer\GAL4^NP5130 leads to a decrease in the proportion of mitotic cells in the adult midgut, as compared to controls.

(Wang et al., 2014)

Expression of Scer\GAL4^{Myo31DF-NP0001}>bsk^{K53R.Scer\UAS} restores lipid levels in aging flies to levels seen in young animals.

Aging flies are more sensitive to starvation, which correlates with age-related changes in glucose and lipid metabolism. Expression of Scer\GAL4^{Myo31DF-NP0001}>bsk^{K53R.Scer\UAS} in enterocytes has no effect on starvation resistance in young animals but leads to significantly improved starvation resistance in older flies compared with wild-type controls.

(Karpac et al., 2013)

Expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^BG380 has no effect on maximum bouton diameter at the larval neuromuscular junction.

(Klinedinst et al., 2013)

Expression of bsk^{K53R.Scer\UAS} in neuronal cells under the control of Scer\GAL4^Cha.7.4 results in a reduced survival rate compared to controls when flies undergo severe wounding.

(Nam et al., 2012)

Expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^C855a does not cause any mutant phenotype in the larval optic lobe.

(Richter et al., 2011)

Compared with controls, female flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^bun-GSG5961 show a moderate, but significant, reduction in intestinal cell proliferation at old age. These flies are significantly longer lived when exposed to RU486 than isogenic siblings exposed to mock treatment.

(Biteau et al., 2010)

Axonal sprouting of the injured axon after a crush injury to the segmental nerve in third instar larvae is significantly inhibited in animals expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^tey-5053A.

(Xiong et al., 2010)

Flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR show a significantly reduced repression of growth (assayed by measuring wing area) when shifted from 25[o]C to 29[o]C compared to wild-type flies.

Flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR are significantly more sensitive to paraquat than control flies.

Flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^{Ilp2.Switch.PK} show increased sensitivity to paraquat compared to controls in the presence of RU486.

(Karpac et al., 2009)

Wing imaginal discs expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096-KE are reduced in size compared to controls.

(Rodahl et al., 2009)

Overexpression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^en-e16E has no effect on the wing.

(Tuxworth et al., 2009)

The size and number of paraquat-induced autophagosomes are reduced in bsk^{K53R.Scer\UAS}-expressing clones in the larval midgut epithelium compared to controls.

Clones of larval intestinal epithelial cells or fat body cells expressing bsk^{K53R.Scer\UAS} show a similar induction of autophagy as in wild type clones upon starvation.

Clones of larval fat body cells expressing bsk^{K53R.Scer\UAS} show a similar induction of autophagy as in wild type clones at the late third instar stage - a stage when animals prepare to pupate and sustained autophagy is observed in these cells.

(Wu et al., 2009)

Expression of bsk^{K53R.Scer\UAS} pan-neuronally under the control of Scer\GAL4^elav-C155 severely reduces synapse size.

(Franciscovich et al., 2008)

Inactivation of the JNK pathway by overexpression of bsk^{K53R.Scer\UAS}, under the control of Scer\GAL4^ap-md544 in the notum results in a thoracic cleft phenotype.

(Cha et al., 2005)

bsk^{K53R.Scer\UAS}; Scer\GAL4^GMR.PF adults have normal eyes.

(Wang et al., 2005)

When bsk^{K53R.Scer\UAS} is driven by Scer\GAL4^αTub84B.PL adult flies exhibit a mild eye disorganisation phenotype.

(Brumby and Richardson, 2003)

Expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^elav-C155 results in a 25-30% decrease in EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction.

(Sanyal et al., 2002)

The cuticles of bsk^{K53R.Scer\UAS}; Scer\GAL4^arm.PS embryos display classic dorsal closure phenotypes (a large dorsal hole of variable size). The prominent actin cable seen in leading edge cells during dorsal closure in wild-type embryos is reduced in these mutants.

(Jasper et al., 2001)

When expression is driven by Scer\GAL4^hs.2sev the eye shows an eye planar polarity phenotype. Some ommatidia are misrotated, and show chirality flips or are symmetrical with variable frequencies. This phenotype is exacerbated by bsk².

(Weber et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hs.2sev, bsk^K53R.UAS has abnormal planar polarity phenotype, enhanceable by Df(3R)crb-F89-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has abnormal planar polarity phenotype, enhanceable by Df(3R)p13/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has abnormal planar polarity phenotype, enhanceable by Df(3R)crb87-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has abnormal planar polarity phenotype, enhanceable by Df(1)H6/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has abnormal planar polarity phenotype, enhanceable by Df(2L)b87e25/+

(Weber et al., 2000)

Suppressed by

Statement

Reference

Scer\GAL4^Ilp2.PR, bsk^K53R.UAS has abnormal stress response phenotype, suppressible by Ilp2^GD15756, Scer\GAL4^Ilp2.PR

(Karpac et al., 2009)

Enhancer of

Statement

Reference

bsk^K53R.UAS, Scer\GAL4^elav-C155 is an enhancer of abnormal neuroanatomy phenotype of α-Spec^KK101541, Scer\GAL4^elav-C155

(Keller et al., 2011)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is an enhancer of neoplasia | larval stage | somatic clone phenotype of scrib¹

(Uhlirova et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of increased cell number | somatic clone | adult stage phenotype of Der-1^Δ

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of increased cell number | somatic clone | adult stage phenotype of Der-1^SH1964

(Liu et al., 2022)

Scer\GAL4^NP5130/bsk^K53R.UAS is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^NP5130, TER94^GL00448

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of increased cell number | somatic clone | adult stage phenotype of TER94^k15502

(Liu et al., 2022)

Scer\GAL4^C587/bsk^K53R.UAS is a suppressor | partially of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

bsk^K53R.UAS, Scer\GAL4^repo is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

bsk^K53R.UAS, Scer\GAL4^repo is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

bsk^K53R.UAS, Scer\GAL4^rn-GAL4-5 is a suppressor of visible | adult stage phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

Scer\GAL4^hh-Gal4/bsk^K53R.UAS is a suppressor | partially of neoplasia | larval stage phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487

(Dekanty et al., 2015)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU, mei-41^GD4258

(Dekanty et al., 2015)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Scer\GAL4^elav.PU/bsk^K53R.UAS is a suppressor | partially of abnormal neuroanatomy | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

Scer\GAL4^ptc-559.1/bsk^K53R.UAS is a suppressor of abnormal cell migration phenotype of Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

bsk^K53R.UAS, Scer\GAL4^ptc-559.1 is a suppressor of abnormal cell migration phenotype of Csk^RNAi.UAS, Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

bsk^K53R.UAS, Scer\GAL4^ptc-559.1 is a suppressor of abnormal cell migration phenotype of BacA\p35^UAS.cHa, Scer\GAL4^ptc-559.1, hid^UAS.cUa

(Rudrapatna et al., 2013)

Scer\GAL4^Ilp2.PR/bsk^K53R.UAS is a suppressor of abnormal starvation stress response phenotype of Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Scer\GAL4^elav.PU/bsk^K53R.UAS is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of shot^VV/shot³

(Valakh et al., 2013)

Scer\GAL4^en-e16E/bsk^K53R.UAS is a suppressor | partially of melanotic mass phenotype | larval stage | nutrition conditional phenotype of MAPk-Ak2^Δ43

(Seisenbacher et al., 2011)

Scer\GAL4^puc-GAL4E69/bsk^K53R.UAS is a suppressor | partially of melanotic mass phenotype | larval stage | nutrition conditional phenotype of MAPk-Ak2^Δ43

(Seisenbacher et al., 2011)

bsk^K53R.UAS, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Rab11^N124I.UAS, Scer\GAL4^GMR.PF

(Tiwari and Roy, 2009)

bsk^K53R.UAS, Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Rab11^RNAi.UAS.WIZ, Scer\GAL4^GMR.PF

(Tiwari and Roy, 2009)

bsk^K53R.UAS, Scer\GAL4^GMR.PF is a suppressor | partially of increased cell death phenotype of Rab11^RNAi.UAS.WIZ, Scer\GAL4^GMR.PF

(Tiwari and Roy, 2009)

bsk^K53R.UAS/Scer\GAL4^Ddc.PL is a suppressor of abnormal neuroanatomy phenotype of hep¹

(Cha et al., 2005)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is a suppressor of increased cell death | somatic clone phenotype of scrib¹

(Uhlirova et al., 2005)

Scer\GAL4^αTub84B.PL/bsk^K53R.UAS is a suppressor of decreased cell number | somatic clone | larval stage phenotype of scrib¹

(Brumby and Richardson, 2003)

Scer\GAL4^hs.2sev/bsk^K53R.UAS is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/bsk^K53R.UAS is a non-suppressor of increased cell death | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

Scer\GAL4^tey-5053A/bsk^K53R.UAS is a non-suppressor of abnormal neuroanatomy | recessive | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Scer\GAL4^Bx-MS1096/bsk^K53R.UAS is a non-suppressor of neoplasia | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, aPKC^ΔN.UAS

(Bunker et al., 2015)

Scer\GAL4^Bx-MS1096/bsk^K53R.UAS is a non-suppressor of neoplasia | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, dlg1^HMS01954

(Bunker et al., 2015)

Scer\GAL4^dpp.PU/bsk^K53R.UAS is a non-suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^dpp.PU, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is a non-suppressor of abnormal cell migration | somatic clone | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, bi^UAS.cPa

(Shen et al., 2014)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of abnormal neurophysiology phenotype of ben¹

(Uthaman et al., 2008)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of abnormal neuroanatomy phenotype of ben¹

(Uthaman et al., 2008)

Other

Statement

Reference

Scer\GAL4^tey-5053A, bsk^K53R.UAS, raw^dcp-1 has abnormal neuroanatomy | third instar larval stage phenotype

(Hao et al., 2019)

Csk^RNAi.UAS, Scer\GAL4^ptc-559.1, Sin3A^KK100700, bsk^K53R.UAS has abnormal size phenotype

(Das et al., 2013)

Scer\GAL4^αTub84B.PL, bsk^K53R.UAS, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, bsk^K53R.UAS has adult thorax phenotype, enhanceable by Scer\GAL4^ap-md544/park[+]/park^UAS.Tag:MYC

(Cha et al., 2005)

Scer\GAL4^ap-md544, bsk^K53R.UAS has mesothoracic cleft | ectopic phenotype, enhanceable by Scer\GAL4^ap-md544/park[+]/park^UAS.Tag:MYC

(Cha et al., 2005)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has eye phenotype, enhanceable by Df(2L)b87e25/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has ommatidium phenotype, enhanceable by Df(2L)b87e25/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has eye phenotype, enhanceable by Df(3R)crb-F89-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has ommatidium phenotype, enhanceable by Df(3R)crb-F89-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has eye phenotype, enhanceable by Df(3R)p13/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has ommatidium phenotype, enhanceable by Df(3R)p13/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has eye phenotype, enhanceable by Df(3R)crb87-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has ommatidium phenotype, enhanceable by Df(3R)crb87-4/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has eye phenotype, enhanceable by Df(1)H6/+

(Weber et al., 2000)

Scer\GAL4^hs.2sev, bsk^K53R.UAS has ommatidium phenotype, enhanceable by Df(1)H6/+

(Weber et al., 2000)

Suppressed by

Statement

Reference

Scer\GAL4^NP5130, bsk^K53R.UAS has midgut | adult stage phenotype, suppressible by Xbp1^GD4745/Scer\GAL4^NP5130

(Wang et al., 2014)

Enhancer of

Statement

Reference

bsk^K53R.UAS, Scer\GAL4^ptc-559.1 is an enhancer of wing disc phenotype of Csk^RNAi.UAS, Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

bsk^K53R.UAS, Scer\GAL4^elav-C155 is an enhancer of embryonic/larval neuromuscular junction phenotype of α-Spec^KK101541, Scer\GAL4^elav-C155

(Keller et al., 2011)

Scer\GAL4^ap-md544/bsk^K53R.UAS is an enhancer of adult thorax phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

Scer\GAL4^ap-md544/bsk^K53R.UAS is an enhancer of mesothoracic cleft | ectopic phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is an enhancer of eye | somatic clone phenotype of scrib¹

(Uhlirova et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of adult midgut epithelium | somatic clone phenotype of Der-1^Δ

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of adult midgut epithelium | somatic clone phenotype of Der-1^SH1964

(Liu et al., 2022)

Scer\GAL4^NP5130/bsk^K53R.UAS is a suppressor of adult midgut progenitor cell | increased number phenotype of Scer\GAL4^NP5130, TER94^GL00448

(Liu et al., 2022)

Scer\GAL4^NP5130/bsk^K53R.UAS is a suppressor of adult midgut progenitor cell | increased number phenotype of Scer\GAL4^NP5130, TER94^HMS00656

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^K53R.UAS is a suppressor of adult midgut epithelium | somatic clone phenotype of TER94^k15502

(Liu et al., 2022)

Scer\GAL4^C587/bsk^K53R.UAS is a suppressor | partially of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

bsk^K53R.UAS, Scer\GAL4^repo is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

bsk^K53R.UAS, Scer\GAL4^repo is a suppressor of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

bsk^K53R.UAS, Scer\GAL4^repo is a suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

bsk^K53R.UAS, Scer\GAL4^rn-GAL4-5 is a suppressor of wing | ectopic phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

Scer\GAL4^hh-Gal4/bsk^K53R.UAS is a suppressor | partially of wing disc phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487

(Dekanty et al., 2015)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU, mei-41^GD4258

(Dekanty et al., 2015)

bsk^K53R.UAS, Scer\GAL4^en.PU is a suppressor of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Scer\GAL4^elav.PU/bsk^K53R.UAS is a suppressor | partially of NMJ bouton | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

Scer\GAL4^elav.PU/bsk^K53R.UAS is a suppressor | partially of embryonic/larval neuromuscular junction | maternal effect | larval stage phenotype of SkpA^GD65

(Brace et al., 2014)

Scer\GAL4^NP5130/bsk^K53R.UAS is a suppressor of midgut | adult stage phenotype of Scer\GAL4^NP5130, Xbp1^GD4745

(Wang et al., 2014)

Scer\GAL4^ptc-559.1/bsk^K53R.UAS is a suppressor of wing disc phenotype of Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

Scer\GAL4^elav.PU/bsk^K53R.UAS is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of shot^VV/shot³

(Valakh et al., 2013)

Scer\GAL4^en-e16E/bsk^K53R.UAS is a suppressor | partially of embryonic/larval hindgut | posterior | larval stage | nutrition conditional phenotype of MAPk-Ak2^Δ43

(Seisenbacher et al., 2011)

Scer\GAL4^puc-GAL4E69/bsk^K53R.UAS is a suppressor | partially of embryonic/larval hindgut | posterior | larval stage | nutrition conditional phenotype of MAPk-Ak2^Δ43

(Seisenbacher et al., 2011)

Scer\GAL4^Bx-MS1096-KE/bsk^K53R.UAS is a suppressor | partially of actin filament & dorsal mesothoracic disc phenotype of Scer\GAL4^Bx-MS1096-KE, Vps4^{DN.UAS.Tag:HA}

(Rodahl et al., 2009)

bsk^K53R.UAS, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Rab11^N124I.UAS, Scer\GAL4^GMR.PF

(Tiwari and Roy, 2009)

bsk^K53R.UAS, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Rab11^RNAi.UAS.WIZ, Scer\GAL4^GMR.PF

(Tiwari and Roy, 2009)

Scer\GAL4^elav-C155/bsk^K53R.UAS is a suppressor of synapse phenotype of Scer\GAL4^elav-C155, sgg^A81T.UAS

(Franciscovich et al., 2008)

Scer\GAL4^BG380/bsk^K53R.UAS is a suppressor of neuromuscular junction phenotype of Scer\GAL4^unspecified, wnd^UAS.cCa

(Collins et al., 2006)

Scer\GAL4^BG380/bsk^K53R.UAS is a suppressor of bouton phenotype of Scer\GAL4^unspecified, wnd^UAS.cCa

(Collins et al., 2006)

Scer\GAL4^BG380/bsk^K53R.UAS is a suppressor of neuromuscular junction phenotype of hiw^ND8

(Collins et al., 2006)

Scer\GAL4^BG380/bsk^K53R.UAS is a suppressor of bouton phenotype of hiw^ND8

(Collins et al., 2006)

bsk^K53R.UAS/Scer\GAL4^Ddc.PL is a suppressor of insulin secreting cell of pars intercerebralis phenotype of hep¹

(Cha et al., 2005)

Scer\GAL4^GMR.PF/bsk^K53R.UAS is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, foxo^UAS.cPa

(Wang et al., 2005)

Scer\GAL4^hs.2sev/bsk^K53R.UAS is a suppressor of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

Scer\GAL4^hs.2sev/bsk^K53R.UAS is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/bsk^K53R.UAS is a non-suppressor of wing disc posterior compartment | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

bsk^K53R.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of wing disc phenotype of Pvr^{λ.UASp.Tag:MYC}, Scer\GAL4^dpp.blk1

(Wang et al., 2023)

Scer\GAL4^tey-5053A/bsk^K53R.UAS is a non-suppressor of axon | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Scer\GAL4^tey-5053A/bsk^K53R.UAS is a non-suppressor of embryonic/larval motor neuron | third instar larval stage | conditional phenotype of raw^dcp-1

(Hao et al., 2019)

Scer\GAL4^Bx-MS1096/bsk^K53R.UAS is a non-suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, dlg1^HMS01954

(Bunker et al., 2015)

Scer\GAL4^Bx-MS1096/bsk^K53R.UAS is a non-suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, aPKC^ΔN.UAS

(Bunker et al., 2015)

Scer\GAL4^dpp.PU/bsk^K53R.UAS is a non-suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^dpp.PU, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is a non-suppressor of wing disc | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^C-765/bsk^K53R.UAS is a non-suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^C-765, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^dpp.PU/bsk^K53R.UAS is a non-suppressor of epithelial cell | third instar larval stage phenotype of Scer\GAL4^dpp.PU, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^Act5C.PI/bsk^K53R.UAS is a non-suppressor of epithelial cell | somatic clone | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^C-765/bsk^K53R.UAS is a non-suppressor of epithelial cell | third instar larval stage phenotype of Scer\GAL4^C-765, bi^UAS.cPa

(Shen et al., 2014)

Scer\GAL4^C-765/bsk^K53R.UAS is a non-suppressor of extracellular matrix | third instar larval stage phenotype of Scer\GAL4^C-765, bi^UAS.cPa

(Shen et al., 2014)

bsk^K53R.UAS, Scer\GAL4^NP5130 is a non-suppressor of adult midgut phenotype of Pvr^CA.UAS, Scer\GAL4^NP5130

(Bond and Foley, 2012)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of giant fiber neuron phenotype of ben¹

(Uthaman et al., 2008)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of mesothoracic tergotrochanter muscle motor neuron phenotype of ben¹

(Uthaman et al., 2008)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of gap junction phenotype of ben¹

(Uthaman et al., 2008)

bsk^K53R.UAS/Scer\GAL4^shot-OK307 is a non-suppressor of synapse phenotype of ben¹

(Uthaman et al., 2008)

Other

Statement

Reference

Scer\GAL4^tey-5053A, bsk^K53R.UAS, raw^dcp-1 has axon | third instar larval stage phenotype

(Hao et al., 2019)

Scer\GAL4^tey-5053A, bsk^K53R.UAS, raw^dcp-1 has embryonic/larval motor neuron | third instar larval stage phenotype

(Hao et al., 2019)

Scer\GAL4^tey-5053A, bsk^K53R.UAS, raw^dcp-1 has varicosity | ectopic | third instar larval stage | conditional phenotype

(Hao et al., 2019)

Csk^RNAi.UAS, Scer\GAL4^ptc-559.1, Sin3A^KK100700, bsk^K53R.UAS has wing disc phenotype

(Das et al., 2013)

Scer\GAL4^Bx-MS1096-KE, Vps4^{DN.UAS.Tag:HA}, bsk^K53R.UAS has wing disc phenotype

(Rodahl et al., 2009)

Cln3^UAS.cTa, Scer\GAL4^en-e16E, bsk^K53R.UAS has wing hair phenotype

(Tuxworth et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

raw^dcp-1 homozygotes show protection against (injury-induced) Wallerian degeneration in third instar larval motor neurons, which is not significantly suppressed by the expression of bsk^K53R.UAS under the control of Scer\GAL4^tey-5053A; in these double mutants, injured axons exhibit severely decreased new growth/sprouting compared to controls, as well as varicosities.

(Hao et al., 2019)

Co-expression of egr^UAS.cUa and bsk^K53R.UAS under the control of Scer\GAL4^rn-GAL4-5 (in combination with tub-Gal80[ts] to restrict expression to early stages of third instar larvae) does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

The co-expression of bsk^{K53R.Scer\UAS} suppresses the tumor phenotype and tissue disorganization resulting from the expression of dlg1^HMS01954, but not from the expression of aPKC^ΔN.Scer\UAS, under the control of Scer\GAL4^Bx-MS1096.

(Bunker et al., 2015)

The synaptic overgrowth phenotype (increase in bouton number) seen at the neuromuscular junction in larvae derived from homozygous SkpA^GD65 females is partially suppressed by expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Brace et al., 2014)

The co-expression of bsk^{K53R.Scer\UAS} does not suppressed the following defects resulting from the expression of bi^Scer\UAS.cBa in third instar larval wing discs: long distance cell migration and scattering, from expression either under the control of Scer\GAL4^dpp.PU or in clones under the control of Scer\GAL4^Act5C.PI; and the basal delamination of cells, resulting from the expression under the control of Scer\GAL4^C-765.

(Shen et al., 2014)

Expression of bsk^{K53R.Scer\UAS} suppresses the cell invasion phenotype seen in wing discs when Sin3A^KK100700 is expressed under the control of Scer\GAL4^ptc-559.1.

Co-expression of Csk^{dsRNA.Scer\UAS} and Sin3A^KK100700 (with Dcr-2^Scer\UAS.cDa) results in a much stronger wing disc cell migration phenotype than is seen when either transgene is expressed alone. Upon co-expression of bsk^{K53R.Scer\UAS}, massive overgrowth is seen, but the invasion phenotype is suppressed.

(Das et al., 2013)

Expression of bsk^{K53R.Scer\UAS} in the insulin-producing cells under the control of Scer\GAL4^Ilp2.PR rescues the starvation resistance seen in itgr[ku] (Itp-r83A^ka1091/Itp-r83A^ug3) mutant flies.

(Subramanian et al., 2013)

Expression of bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^elav.PU suppresses the increase in bouton number seen at the neuromuscular junction in shot³/shot^VV third instar larvae.

(Valakh et al., 2013)

Co-expression of Pvr^CA.Scer\UAS and bsk^{K53R.Scer\UAS} in 3-5 day old adult flies, under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B phenocopies the proliferation of Scer\GAL4^esg-NP5130>GFP-positive cells observed upon expression of Pvr^CA.Scer\UAS alone.

(Bond and Foley, 2012)

Expression of bsk^{K53R.Scer\UAS} enhances the synaptic degeneration phenotype seen when α-Spec^KK101541 is expressed under the control of Scer\GAL4^elav-C155.

(Keller et al., 2011)

Expression of bsk^{K53R.Scer\UAS} under the control of either Scer\GAL4^en-e16E or Scer\GAL4^puc-GAL4E69 partially suppresses the "black dot" phenotype seen in MAPk-Ak2^Δ43 larvae.

(Seisenbacher et al., 2011)

Co-expression of Ilp2^GD15756 efficiently rescues the repression of growth when shifted from 25[o]C to 29[o]C in flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR.

Co-expression of Ilp2^GD15756 rescues the increased sensitivity to paraquat of flies expressing bsk^{K53R.Scer\UAS} under the control of Scer\GAL4^Ilp2.PR.

(Karpac et al., 2009)

The disruption of the actin cytoskeleton that is seen in the wing imaginal discs of animals expressing Vps4^{DN.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Bx-MS1096-KE is partially suppressed by co-expression of bsk^{K53R.Scer\UAS}.

Wing imaginal discs co-expressing both bsk^{K53R.Scer\UAS} and Vps4^{DN.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Bx-MS1096-KE overgrow and are larger in size compared to controls.

(Rodahl et al., 2009)

The reduced eye size caused by expression of Rab11^{N124I.Scer\UAS} under the control of Scer\GAL4^GMR.PF is significantly suppressed by co-expression of bsk^{K53R.Scer\UAS}.

(Tiwari and Roy, 2009)

Overexpression of both bsk^{K53R.Scer\UAS} and cln3^Scer\UAS.cTa under the control of Scer\GAL4^en-e16E produces clones of cells in the wings with multiple bristles.

(Tuxworth et al., 2009)

Co-expression of bsk^{K53R.Scer\UAS} and sgg^{A81T.Scer\UAS} pan-neuronally under the control of Scer\GAL4^elav-C155 severely and significantly reduces synapse size compared to synapses in Scer\GAL4^elav-C155-sgg^{A81T.Scer\UAS} flies.

(Franciscovich et al., 2008)

Expression of bsk^{K53R.Scer\UAS} in a ben¹ mutant background does not suppress the giant fiber axonal overgrowth phenotype found in these mutants.

(Uthaman et al., 2008)

Expression of bsk^{K53R.Scer\UAS} (under the control of Scer\GAL4^BG380) suppresses the hiw^ND8 synaptic phenotype, reducing the number of synaptic boutons and branches and increasing bouton size and the intensity of synaptic vesicle markers.

(Collins et al., 2006)

Ectopic expression of bsk^{K53R.Scer\UAS}, under the regulatory control of Scer\GAL4^Ddc.PL in hep¹ mutants restores the morphology of dorsomedial dopaminergic neuron. The thoracic cleft formation observed in park^{Scer\UAS.T:Hsap\MYC} overexpression mutants (Scer\GAL4^ap-md544) and bsk^{K53R.Scer\UAS} mutants is mutually enhanced by their co-expression.

(Cha et al., 2005)

Downregulation of JNK signaling in clones of scrib^unspecified mutant tissue by overexpression of bsk^{K53R.Scer\UAS} suppresses apoptosis (from 16.6% to wild-type levels of 25%) and increases the overgrowth of the tissue, even compared to wild-type, resulting in scrib^unspecified bsk^{K53R.Scer\UAS} clones contributing over 70% of the tissue in third instar eye imaginal discs.

(Uhlirova et al., 2005)

The small, deformed eye phenotype of foxo^Scer\UAS.cPa; Scer\GAL4^GMR.PF adults is largely suppressed by bsk^{K53R.Scer\UAS}.

(Wang et al., 2005)

When bsk^{K53R.Scer\UAS} is driven by Scer\GAL4^αTub84B.PL in scrib¹ clones in the eye, a significant increase in the size of scrib¹ clones is seen. However, this combination leads to pupal lethality.

(Brumby and Richardson, 2003)

Xenogenetic Interactions

Statement

Reference

The enlarged wing disc posterior compartment observed upon exposure to ionizing radiation of individuals expressing BacA\p35^UAS.cHa alone, or in combination with either okr^KK107487 or mei-41^GD4258, is suppressed by the additional co-expression of bsk^K53R.UAS.

The additional co-expression of bsk^K53R.UAS suppresses the longer DNA damage response to an exposure to ionizing radiation (assessed by phospho-H2Av immunostaining) in the wing disc posterior compartment observed in individuals co-expressing BacA\p35^UAS.cHa and either okr^KK107487 or mei-41^GD4258 under the control of Scer\GAL4^en.PU.

(Dekanty et al., 2015)

The BacA\p35^Scer\UAS.cHa-W^Scer\UAS.cUa invasive cell phenotype is completely suppressed by co-expression of bsk^{K53R.Scer\UAS}.

(Rudrapatna et al., 2013)

Complementation and Rescue Data

Comments

ameliorates cancer ; DOID:162 | modeled by hid^Scer\UAS.cUa, BacA\p35^Scer\UAS.cHa

(Rudrapatna et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9311

w^*; P{UAS-bsk.K53R}20.1a

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Bsk^DN

(Weber et al., 2000)

BskK53R

(Weber et al., 2000)

Jnk^DN

(Valakh et al., 2013)

bsk^{K53R.Scer\UAS}

bsk^K53R.UAS

Name Synonyms

Secondary FlyBase IDs

References (78)

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