FlyBase Allele Report: Xlae\Gli1[UAS.Tag:MYC]

General Information

Symbol

Xlae\Gli1^UAS.Tag:MYC

Species

X. laevis

Name

FlyBase ID

FBal0119328

Feature type

allele

Associated gene

Xlae\Gli1

Associated Insertion(s)

Carried in Construct

P{UAS-Myc-Xlae\Gli1}

Also Known As

UAS-Myc-Gli1

Transgenic product class

cDNA

(Aza-Blanc et al., 2000)

wild_type

(Aza-Blanc et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Aza-Blanc et al., 2000)

wild_type

(Aza-Blanc et al., 2000)

Mutagen

in vitro construct

(Aza-Blanc et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Myc-Xlae\Gli1}

Cytology

Description

UASt regulatory sequences drive expression of a Xlae\Gli1 cDNA tagged with six N-terminal Tag:MYC tags.

(Aza-Blanc et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Xlae\Gli1

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^en-e16E

(Aza-Blanc et al., 2000)

Phenotype Manifest In

wing blade posterior compartment, with Scer\GAL4^en-e16E

(Aza-Blanc et al., 2000)

wing vein L4, with Scer\GAL4^en-e16E

(Aza-Blanc et al., 2000)

Detailed Description

Statement

Reference

Expression of Xlae\Gli1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ptc-559.1 does not alter wing vein morphology or growth. Expression of Xlae\Gli1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E results in alteration of vein pattern and overgrowth in the posterior wing compartment. Portions of wing vein 4 are frequently missing, but proximal vein 4 is usually visible and is never fused with wing vein 3.

(Aza-Blanc et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, Xlae\Gli1^UAS.Tag:MYC has visible phenotype, suppressible | partially by fu¹

(Aza-Blanc et al., 2000)

Suppressor of

Statement

Reference

Scer\GAL4^en-e16E/Xlae\Gli1^UAS.Tag:MYC is a suppressor of visible phenotype of fu¹

(Aza-Blanc et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, Xlae\Gli1^UAS.Tag:MYC has wing phenotype, suppressible | partially by fu¹

(Aza-Blanc et al., 2000)

Suppressor of

Statement

Reference

Scer\GAL4^en-e16E/Xlae\Gli1^UAS.Tag:MYC is a suppressor of wing phenotype of fu¹

(Aza-Blanc et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The wing overgrowth phenotype caused by expression Xlae\Gli1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E is partially suppressed by fu¹, while the defect seen in the intervein region between veins 3 and 4 in fu¹ flies is partially rescued by the expression Xlae\Gli1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E.

(Aza-Blanc et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid and transfected into S2 cells.

(Aza-Blanc et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Xlae\Gli1^{Scer\UAS.T:Hsap\MYC}

Xlae\Gli1^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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