FlyBase Allele Report: Dmel\Rab11[EP3017]

(Kohrs et al., 2021, Warner and Longmore, 2009, Gene Disruption Project members, 2001-, Jankovics et al., 2001, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | male (with Rab11^93Bi)

(Giansanti et al., 2007)

abnormal meiotic cell cycle | male (with Rab11^93Bi)

(Giansanti et al., 2007)

cell lethal | recessive | somatic clone

(Satoh et al., 2005)

female sterile (with Rab11^93Bi)

(Jankovics et al., 2001)

lethal

(Kohrs et al., 2021, Giansanti et al., 2007)

lethal (with Df(3R)e-R1)

(Giansanti et al., 2007)

lethal (with Rab11^ETo3)

(Giansanti et al., 2007)

lethal (with Rab11^ETo11)

(Giansanti et al., 2007)

lethal | recessive

(Jankovics et al., 2001)

lethal - all die before end of first instar larval stage | recessive

(Alone et al., 2005)

lethal - all die before end of larval stage (with Rab11^mo)

(Alone et al., 2005)

partially lethal - majority die (with Rab11^93Bi)

(Giansanti et al., 2007)

some die during first instar larval stage | recessive

(Alone et al., 2005)

some die during larval stage (with Rab11^mo)

(Alone et al., 2005)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

visible | somatic clone

(Alone et al., 2005)

Phenotype Manifest In

amnioserosa

(Sasikumar and Roy, 2009)

amnioserosa (with Df(3R)e-R1)

(Sasikumar and Roy, 2009)

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

egg chamber | germline clone

(Jankovics et al., 2001)

embryonic dorsal epidermis

(Sasikumar and Roy, 2009)

embryonic dorsal epidermis (with Df(3R)e-R1)

(Sasikumar and Roy, 2009)

embryonic leading edge cell

(Sasikumar and Roy, 2009)

embryonic leading edge cell (with Df(3R)e-R1)

(Sasikumar and Roy, 2009)

eye photoreceptor cell | somatic clone

(Alone et al., 2005)

interommatidial bristle (with Rab11^mo)

(Alone et al., 2005)

interommatidial bristle | somatic clone

(Alone et al., 2005)

macrochaeta (with Rab11^93Bi)

(Jankovics et al., 2001)

multivesicular body & eye photoreceptor cell | somatic clone

(Satoh et al., 2005)

Nebenkern (with Rab11^93Bi)

(Giansanti et al., 2007)

ommatidium (with Rab11^mo)

(Alone et al., 2005)

rhabdomere | somatic clone

(Satoh et al., 2005)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

spermatid (with Rab11^93Bi)

(Giansanti et al., 2007)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

Approximately 50% of homozygous stage 13-14 embryos have abnormally shaped and less elongated lateral epidermal cells than normal. 35% of homozygous embryos show intermittent loss of PTyr-enriched actin-nucleating centers that form between neighbouring dorsal-most epidermal cells. Some of the mutant embryos show widening of some of the dorsal-most epidermal cells and disruptions in the leading edge. The embryos show partial to near complete disruptions of the cell boundaries of the amnioserosa. Rab11^EP3017/Df(3R)e-R1 embryos show similar defects in the dorsal-most epidermal cells, amnioserosa and the lateral epidermis, at a comparable penetrance.

(Sasikumar and Roy, 2009)

Testes from Rab11^93Bi/Rab11^EP3017 larvae have spermatids composed of an abnormally large Nebenkern associated with multiple nuclei.

(Giansanti et al., 2007)

Homozygous clones in the eye lack all photoreceptor cells and lack interommatidial bristles.

Adult Rab11^mo/Rab11^EP3017 escapers have eye defects including fused ommatidia and missing bristles.

(Alone et al., 2005)

Few mutant photoreceptors are seen in mosaic eyes, probably reflecting a cell-essential role for Rab11. These mutant photoreceptors are reduced in size and a profusion of vesicles fills the photoreceptor cytoplasm. The normal multivesicular bodies (MVBs) are missing in these mutant cells, but infrequently, irregular vesicular organelles resembling defective MVBs are seen. The ER and Golgi have a normal appearance in these cells.

(Satoh et al., 2005)

Egg chambers older than stage 4 are never detected in females containing homozygous germ-line clones.

(Jankovics et al., 2001)

Expression of Rab11^EP3017 under the control of Scer\GAL4^sca-537.4 results in the loss of scutellar and dorsocentral macrochaetae. Sensory organs with no socket, one shaft and one sheath cell are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Rab11^EP3017, Scer\GAL4^sca-537.4 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by