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General Information
Symbol
Dmel\Rab11EP3017
Species
D. melanogaster
Name
FlyBase ID
FBal0119426
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion at +222bp of the transcription unit (the CDS starts at +189bp).

Insertion components
P{EP}Rab11EP3017
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Approximately 50% of homozygous stage 13-14 embryos have abnormally shaped and less elongated lateral epidermal cells than normal. 35% of homozygous embryos show intermittent loss of PTyr-enriched actin-nucleating centers that form between neighbouring dorsal-most epidermal cells. Some of the mutant embryos show widening of some of the dorsal-most epidermal cells and disruptions in the leading edge. The embryos show partial to near complete disruptions of the cell boundaries of the amnioserosa. Rab11EP3017/Df(3R)e-R1 embryos show similar defects in the dorsal-most epidermal cells, amnioserosa and the lateral epidermis, at a comparable penetrance.

Testes from Rab1193Bi/Rab11EP3017 larvae have spermatids composed of an abnormally large Nebenkern associated with multiple nuclei.

Homozygous clones in the eye lack all photoreceptor cells and lack interommatidial bristles.

Adult Rab11mo/Rab11EP3017 escapers have eye defects including fused ommatidia and missing bristles.

Few mutant photoreceptors are seen in mosaic eyes, probably reflecting a cell-essential role for Rab11. These mutant photoreceptors are reduced in size and a profusion of vesicles fills the photoreceptor cytoplasm. The normal multivesicular bodies (MVBs) are missing in these mutant cells, but infrequently, irregular vesicular organelles resembling defective MVBs are seen. The ER and Golgi have a normal appearance in these cells.

Egg chambers older than stage 4 are never detected in females containing homozygous germ-line clones.

Expression of Rab11EP3017 under the control of Scer\GAL4sca-537.4 results in the loss of scutellar and dorsocentral macrochaetae. Sensory organs with no socket, one shaft and one sheath cell are seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Order of alleles (based on transheterozygous sterile phenotype): Rab1193Bi < Rab11j2D1 < Rab11EP3017 = Rab11ETo11 = Rab11ETo3 < Df(3R)e-N19.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)