Open Close
General Information
Symbol
Hsap\GLI3UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0119473
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a Hsap\GLI3 cDNA tagged with six N-terminal Tag:MYC tags.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\GLI3Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ptc-559.1 does not alter wing vein morphology or growth. Expression of Hsap\GLI3Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4en-e16E does not induce growth or vein pattern alteration in the wing, although wing veins 3 and 4 are slightly fused.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Enhancer of
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of both Hsap\GLI3Scer\UAS.T:Hsap\MYC and ptcScer\UAS.cJa under the control of Scer\GAL4en-e16E at 17oC results in an enhancing, synergistic effect; the wings are significantly reduced in size. The central region of the wing, including veins 3 and 4 is absent. Higher levels of expression of both Hsap\GLI3Scer\UAS.T:Hsap\MYC and ptcScer\UAS.cJa under the control of Scer\GAL4en-e16E result in lethality.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Carried in a plasmid and transfected into S2 cells to study the behaviour of the Hsap\GLI3 protein in these cells.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\GLI3Scer\UAS.T:Hsap\MYC
Hsap\GLI3UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (2)