FlyBase Allele Report: Hsap\ATXN1[82Q.UAS]

General Information

Symbol

Hsap\ATXN1^82Q.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0119474

Feature type

allele

Associated gene

Hsap\ATXN1

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\ATX1.82Q}

Also Known As

UAS-SCA1^82Q, UAS-ATXN1(82Q), UAS-ATXN1^82Q, SCA1^82Q, UAS:SCA1 82Q, UAS-Atxn1-82Q, ATXN1(82Q), Atxn1-82Q, UAS-SCA182Q, UAS-ATX1.82Q

Key Links

Transgenic product class

trinucleotide_repeat_expansion

(Fernandez-Funez et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Fernandez-Funez et al., 2000)

Mutagen

in vitro construct

(Fernandez-Funez et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Hsap\ATX1.82Q}

Cytology

Description

A Hsap\ATXN1 cDNA containing 82 CAG repeats is driven by UASt sequences.

(Fernandez-Funez et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\ATXN1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal dominant cerebellar ataxia

CEA

(Ruan et al., 2015, Reinhardt et al., 2012, Al-Ramahi et al., 2007, Al-Ramahi et al., 2006, Fernandez-Funez et al., 2000)

model of olivopontocerebellar atrophy

CEA

(Lee et al., 2011, Lim et al., 2008)

model of neurodegenerative disease

CEA

(Mallik and Lakhotia, 2009, Tamura et al., 2009, Zhai et al., 2008, Qi et al., 2007, Lam et al., 2006)

model of spinocerebellar ataxia type 1

CEA

(Olmos et al., 2024, Palmer et al., 2024, Prange et al., 2024, Lee et al., 2021, Suart et al., 2021, Tazelaar et al., 2020, Chung et al., 2017, Del Caño-Espinel et al., 2015, Shiraishi et al., 2014, Arribat et al., 2013)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal dominant cerebellar ataxia

is exacerbated by Nmnat^UAS.PC

(Ruan et al., 2015)

is ameliorated by Nmnat^UAS.PD

(Ruan et al., 2015)

is ameliorated by Hsap\STUB1^UAS.cAa

(Al-Ramahi et al., 2006)

is exacerbated by lncRNA:Hsrω^neo55

(Fernandez-Funez et al., 2000)

is exacerbated by Sirt1^EP2300

(Fernandez-Funez et al., 2000)

is exacerbated by cpo^EP3378

(Fernandez-Funez et al., 2000)

is ameliorated by GstE1^EP2231

(Fernandez-Funez et al., 2000)

is exacerbated by tara^EP3463

(Fernandez-Funez et al., 2000)

is exacerbated by Ythdc1^EP3725

(Fernandez-Funez et al., 2000)

is exacerbated by Tecr⁰⁵⁶³⁴

(Fernandez-Funez et al., 2000)

is exacerbated by HDAC1^EP3672

(Fernandez-Funez et al., 2000)

is exacerbated by pum^EP3461

(Fernandez-Funez et al., 2000)

is ameliorated by DnaJ-1^EP411

(Fernandez-Funez et al., 2000)

is ameliorated by mub^EP3623

(Fernandez-Funez et al., 2000)

is exacerbated by skd^L7062

(Fernandez-Funez et al., 2000)

is exacerbated by Sin3A^EP866

(Fernandez-Funez et al., 2000)

is exacerbated by UbcE2H^EP1303

(Fernandez-Funez et al., 2000)

is exacerbated by eff^EP674

(Fernandez-Funez et al., 2000)

is exacerbated by CtBP⁰³⁴⁶³

(Fernandez-Funez et al., 2000)

is exacerbated by eff⁸

(Fernandez-Funez et al., 2000)

is ameliorated by Nup44A^EP2417

(Fernandez-Funez et al., 2000)

is exacerbated by Atx2^UAS.cSa

(Al-Ramahi et al., 2007)

is exacerbated by Akt^UAS.Tag:HA

(Chen et al., 2003)

is ameliorated by Akt⁰⁴²²⁶

(Chen et al., 2003)

is exacerbated by 14-3-3ε^UAS.cCa

(Chen et al., 2003)

is exacerbated by Pi3K92E^UAS.Tag:MYC

(Chen et al., 2003)

is ameliorated by Wnk^KK102654

(Park et al., 2013)

is ameliorated by BubR1^DN.UAS

(Park et al., 2013)

is ameliorated by Sdr^KK104654

(Park et al., 2013)

is ameliorated by Aduk^KK102129

(Park et al., 2013)

is ameliorated by JIL-1^KK101300

(Park et al., 2013)

is ameliorated by JIL-1^KG08229

(Park et al., 2013)

is ameliorated by lic^KK108550

(Park et al., 2013)

is ameliorated by Dsor1^G79

(Park et al., 2013)

is ameliorated by drk^KG03077

(Park et al., 2013)

is ameliorated by rl¹

(Park et al., 2013)

is ameliorated by Sos^KG10074

(Park et al., 2013)

is ameliorated by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

is ameliorated by Ras64B^GD1517

(Park et al., 2013)

is ameliorated by Raf^KK100982

(Park et al., 2013)

is ameliorated by Fntb^KK108342

(Park et al., 2013)

is ameliorated by Fnta^KK100303

(Park et al., 2013)

is ameliorated by PICK1^KK109273

(McGurk and Bonini, 2012)

model of olivopontocerebellar atrophy

is ameliorated by Spf45^J23

(Lim et al., 2008)

is ameliorated by DnaJ-1^EP411

(Branco et al., 2008)

is ameliorated by Hsap\STUB1^UAS.cAa

(Branco et al., 2008)

is exacerbated by Sin3A^dQ4

(Branco et al., 2008)

is exacerbated by skd^L7062

(Branco et al., 2008)

is exacerbated by GstS1⁰⁶²⁵³

(Branco et al., 2008)

is ameliorated by vib^EP513

(Branco et al., 2008)

is ameliorated by Diap1^{UAS.cHa.Tag:MYC}

(Branco et al., 2008)

is exacerbated by tara^EP3463

(Branco et al., 2008)

is exacerbated by cpo^EP3378

(Branco et al., 2008)

is exacerbated by pum^EP3461

(Branco et al., 2008)

is exacerbated by Hsc70-3^K97S.UAS

(Branco et al., 2008)

is exacerbated by eff⁸

(Branco et al., 2008)

is exacerbated by Sirt1^EP2300

(Branco et al., 2008)

is ameliorated by pum^bem

(Branco et al., 2008)

is exacerbated by Diap1⁴

(Branco et al., 2008)

is exacerbated by 14-3-3ε^UAS.cCa

(Branco et al., 2008)

is exacerbated by lncRNA:Hsrω^neo55

(Branco et al., 2008)

is ameliorated by 14-3-3ε^ex4

(Branco et al., 2008)

is ameliorated by 14-3-3ε^j2B10

(Branco et al., 2008)

is exacerbated by HDAC1⁰⁴⁵⁵⁶

(Branco et al., 2008)

is exacerbated by CtBP⁰³⁴⁶³

(Branco et al., 2008)

is exacerbated by RhoGAPp190^EP1357

(Branco et al., 2008)

is exacerbated by Tecr⁰⁵⁶³⁴

(Branco et al., 2008)

is ameliorated by ps³

(Branco et al., 2008)

is ameliorated by ps^j449

(Branco et al., 2008)

is ameliorated by Nup44A^EP2417

(Branco et al., 2008)

is exacerbated by Akt^UAS.Tag:HA

(Branco et al., 2008)

is ameliorated by Akt⁰⁴²²⁶

(Branco et al., 2008)

is ameliorated by mub^EP3623

(Branco et al., 2008)

is exacerbated by mub⁰⁴⁰⁹³

(Branco et al., 2008)

is ameliorated by vib^EP651

(Branco et al., 2008)

is exacerbated by sov^KG00226

(Branco et al., 2008)

is ameliorated by sov^KG00226

(Branco et al., 2008)

is exacerbated by Pi3K92E^UAS.Tag:MYC

(Branco et al., 2008)

is exacerbated by Hsap\NLK^UAS.cJa

(Ju et al., 2013)

is ameliorated by nmo^adk2

(Ju et al., 2013)

model of neurodegenerative disease

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Nmnat^UAS.cZa

(Zhai et al., 2008)

is ameliorated by Nmnat^WR.UAS.PD

(Zhai et al., 2008)

is exacerbated by grp^GS22185

(Barclay et al., 2014)

is ameliorated by RPA1^GS10684

(Barclay et al., 2014)

is exacerbated by RPA1^NIG.9633R

(Barclay et al., 2014)

is ameliorated by RecQ5^GS9658

(Barclay et al., 2014)

is ameliorated by grp^NIG.17161R

(Barclay et al., 2014)

model of spinocerebellar ataxia type 1

is exacerbated by Hsap\TARDBP^GMR.PJ

(Tazelaar et al., 2020)

is exacerbated by Zzzz\poly-GR^PO-36.UAS

(Tazelaar et al., 2020)

is ameliorated by tefu^KK100008

(Suart et al., 2021)

is ameliorated by tefu^MB09945

(Suart et al., 2021)

is exacerbated by Hsap\RBFOX1^UAS.Tag:HA

(Olmos et al., 2024)

is ameliorated by Rbfox1^HMS00478

(Olmos et al., 2024)

is ameliorated by GLaz^4.2kb.GFP

(Del Caño-Espinel et al., 2015)

is ameliorated by NLaz^UAS.cHTa

(Del Caño-Espinel et al., 2015)

is exacerbated by Hsap\ZBTB7B^UAS.cLa

(Lee et al., 2021)

is ameliorated by S6kII^HMC03140

(Lee et al., 2021)

is ameliorated by S6kII^KK109199

(Lee et al., 2021)

is exacerbated by S6kII^UAS.cBa

(Lee et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Fernandez-Funez et al., 2000)

ATXN1:p.Gln197[82]

(FlyBase curators, 2019-)

Variants Synonym(s)

ATXN1:p.Gln197[82Gln]

ATXN1, (CAG)n REPEAT EXPANSION

Associated human disease model(s)

spinocerebellar ataxia 1

External database links

ClinVar: ATXN1_8071

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

abnormal eye color, with Scer\GAL4^GMR.PU

(Ju et al., 2013)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nrv2.PS

(Ruan et al., 2015, Branco et al., 2008)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nrv2.PU

(Al-Ramahi et al., 2007)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Zhai et al., 2008)

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Lee et al., 2011)

abnormal neuroanatomy | pupal stage, with Scer\GAL4^gcm.PU

(Tamura et al., 2009)

abnormal neuroanatomy | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

increased cell death, with Scer\GAL4^GMR.PU

(Ju et al., 2013)

increased cell death | adult stage, with Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

lethal - all die before end of pupal stage, with Scer\GAL4^gcm.PU

(Tamura et al., 2009)

lethal - all die during embryonic stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

lethal - all die during pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

partially lethal, with Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

short lived, with Scer\GAL4^nrv2.PU

(Al-Ramahi et al., 2007)

short lived, with Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Reinhardt et al., 2012)

some die during embryonic stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

some die during third instar larval stage, with Scer\GAL4^gcm.PU

(Tamura et al., 2009)

visible, with Scer\GAL4^cv-c-C5

(Lam et al., 2006)

visible, with Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006, Lam et al., 2006)

visible, with Scer\GAL4^GMR.PU

(Ju et al., 2013, McGurk and Bonini, 2012)

visible | adult stage, with Scer\GAL4^GMR.PF

(Lim et al., 2008)

visible | adult stage, with Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

visible | adult stage, with Scer\GAL4^GMR.PU

(Park et al., 2021, Qurashi et al., 2012, Branco et al., 2008, Al-Ramahi et al., 2007)

Phenotype Manifest In

adult brain, with Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

adult head | pupal stage, with Scer\GAL4^gcm.PU

(Tamura et al., 2009)

axon | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

dendrite | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

eye, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009, Lim et al., 2008, Zhai et al., 2008, Chen et al., 2003, Fernandez-Funez et al., 2000)

eye, with Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

eye, with Scer\GAL4^GMR.PU

(Park et al., 2021, Ju et al., 2013, McGurk and Bonini, 2012, Qurashi et al., 2012, Branco et al., 2008)

eye, with Scer\GAL4^ninaE.PT

(Tsuda et al., 2005)

eye | adult stage, with Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

eye photoreceptor cell, with Scer\GAL4^ninaE.PT

(Tsuda et al., 2005)

eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

interneuron, with Scer\GAL4^VNC.ap

(Fernandez-Funez et al., 2000)

interneuron & axon, with Scer\GAL4^VNC.ap

(Fernandez-Funez et al., 2000)

interneuron & cell body, with Scer\GAL4^VNC.ap

(Fernandez-Funez et al., 2000)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Lim et al., 2008, Al-Ramahi et al., 2006, Lam et al., 2006, Tsuda et al., 2005)

interommatidial bristle, with Scer\GAL4^GMR.PU

(Branco et al., 2008)

interommatidial bristle | adult stage, with Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

lamina | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PG

(Lee et al., 2011)

macrochaeta | adult stage, with Scer\GAL4^sca-109-68

(Al-Ramahi et al., 2007)

mesothoracic bristle, with Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

metathoracic bristle, with Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

microtubule | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

neuron | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

neuropil | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

ommatidium, with Scer\GAL4^GMR.PF

(Lim et al., 2008, Al-Ramahi et al., 2006, Lam et al., 2006, Tsuda et al., 2005)

ommatidium, with Scer\GAL4^GMR.PU

(Branco et al., 2008)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

posterior crossvein, with Scer\GAL4^cv-c-C5

(Lam et al., 2006)

pupal brain, with Scer\GAL4^gcm.PU

(Tamura et al., 2009)

retina, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009, Al-Ramahi et al., 2006, Chen et al., 2003, Fernandez-Funez et al., 2000)

retina, with Scer\GAL4^GMR.PU

(Fujita et al., 2013, Branco et al., 2008)

retina | adult stage, with Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

retina | pupal stage, with Scer\GAL4^repo

(Tamura et al., 2009)

rhabdomere, with Scer\GAL4^GMR.PF

(Chen et al., 2003)

rhabdomere of eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Zhai et al., 2008)

wing, with Scer\GAL4^bbg-C96

(Tsuda et al., 2005)

wing, with Scer\GAL4^cv-c-C5

(Lam et al., 2006, Tsuda et al., 2005)

wing margin bristle, with Scer\GAL4^bbg-C96

(Tsuda et al., 2005)

wing vein | ectopic, with Scer\GAL4^cv-c-C5

(Lam et al., 2006)

wing vein | ectopic, with Scer\GAL4^GMR.PF

(Tsuda et al., 2005)

wing vein | heat sensitive, with Scer\GAL4^cv-c-C5

(Tsuda et al., 2005)

wing vein L3, with Scer\GAL4^cv-c-C5

(Lam et al., 2006)

Detailed Description

Statement

Reference

Expression of Hsap\ATXN1^82Q.Scer\UAS driven by Scer\GAL4^nrv2.PS induces an age-dependent (significant at day 10 and 20 but not day 1) decline in climbing performance and signs of apoptosis in the adult brain (2 day old female).

(Ruan et al., 2015)

Increased DNA damage is seen in the motor neurons of flies expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^RapGAP1-OK6 compared to controls.

A shortened lifespan is observed when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6. Feeding flies with a specific inhibitor of grp (CHIR-24) suppresses this phenotype in a concentrations-dependent manner.

(Barclay et al., 2014)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PU results in reduced retina thickness compared to controls.

(Fujita et al., 2013)

Expression of Hsap\ATXN1^82Q.Scer\UAS in the eye under the control of Scer\GAL4^GMR.PU results in retinal depigmentation, disruption of the structured eye pattern and retinal degeneration. The eye is yellow-colored and occasionally shows necrotic patches on the external surface.

(Ju et al., 2013)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PF induces an external eye phenotype and photoreceptor degeneration compared to controls. Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^nrv2.PS leads to a decreased in adult lifespan compared to controls.

(Park et al., 2013)

Larval ddaE neurons expressing Hsap\ATXN1^82Q.UAS under the control of Scer\GAL4²²¹ show a significant increase in growing microtubules within dendrites, as compared to neurons in controls.

(Chen et al., 2012)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Qurashi et al., 2012)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^{elav.Switch.PO} during the adult stage (using RU486) results in a reduction in mean lifespan compared to controls.

(Reinhardt et al., 2012)

Larvae expressing Hsap\ATXN1^82Q.Scer\UAS in class IV da neurons under the control of Scer\GAL4^ppk.PG exhibit striking dendritic abnormalities compared to controls. Terminal dendritic branching and complexity is greatly reduced compared to controls, whereas the major dendrite branches are unaffected.

Expression of Hsap\ATXN1^82Q.Scer\UAS in dorsal cluster neurons under the control of Scer\GAL4^109(2)80 results in a reduction in F-actin structures in distal dendrites.

(Lee et al., 2011)

Expression of Hsap\ATX1^82Q.Scer\UAS using Scer\GAL4^GMR.PF results in depigmented eyes with moderate roughening; ommatidial arrays are intact although a little disorganized.

Expression of Hsap\ATX1^82Q.Scer\UAS using Scer\GAL4^elav-C155 results in death of 48% of progeny as early embryos and the rest before adult emergence.

(Mallik and Lakhotia, 2009)

Some (~50%) of Scer\GAL4^gcm.PU Hsap\ATXN1^82Q.Scer\UAS pupae have remarkably small heads.

Head size is not significantly affected in Scer\GAL4^repo Hsap\ATXN1^82Q.Scer\UAS pupae.

In mild cases, Scer\GAL4^gcm.PU Hsap\ATXN1^82Q.Scer\UAS pupal brains show a relatively normal gross structure, whereas the size of each brain structure is 50-60% of normal length. Vacuolations are observed in some parts. In severe cases the brain structure is severely destroyed and the relationship to surrounding head tissues is distorted.

The gross structure of the brain is relatively preserved in Scer\GAL4^repo Hsap\ATXN1^82Q.Scer\UAS pupae. However, neuropils are coarse and the number of neurons, especially photoreceptor neurons in the retina, is reduced.

The number and density of neurons surrounding optic lobes is remarkably decreased, the number of axons from photoreceptor neurons is reduced, and the axonal pathway from retina to lamina and lamina to medulla is remarkably distorted in Scer\GAL4^gcm.PU Hsap\ATXN1^82Q.Scer\UAS and especially in Scer\GAL4^repo Hsap\ATXN1^82Q.Scer\UAS pupal brains.

(Tamura et al., 2009)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PU causes an external eye phenotype consisting of ommatidial disorganisation and interommatididal bristle loss.The flies exhibit a retinal phenotype, characterized by a decrease in the length of the retina, tissue loss and shortened and abnormal photoreceptor neurons.

Flies expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^nrv2.PS exhibit progressive climbing defects.

(Branco et al., 2008)

Flies expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PF at 30[o]C exhibit retinal degeneration, ommatidial disorganisation and fusion and interommatidial bristle loss. A less severe phenotype is seen at 25[o]C.

(Lim et al., 2008)

Expression of Scer\GAL4^GMR.PF>Hsap\ATXN1^82Q.Scer\UAS leads to rough eye and reduced rhabdomere size.

(Zhai et al., 2008)

Expression of Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PU results in disorganized ommatidia and interommatidial bristles, tissue loss in the retina as well as morphological defects in the photoreceptor neurons of adult eye. Expression under the Scer\GAL4^nrv2.PU driver leads to age-progressive impairment of the locomotor performance (in a climbing assay) and shorter lifespan of the adult flies compared to controls. Expression under the control of Scer\GAL4^sca-109-68 leads to a mild loss of macrochaete in the adult thorax.

(Al-Ramahi et al., 2007)

Flies expressing Hsap\ATX1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PF have a severe external eye phenotype with disorganised and fused ommatidia and loss of interommatidial bristles. There is severe retinal degeneration, as evident by reduction in depth of the retina.

(Al-Ramahi et al., 2006)

Expression of Hsap\ATX1^82Q.Scer\UAS in the eye, under the control of Scer\GAL4^GMR.PF, causes ommatidial disorganization and fusion, as well as interommatidial bristle loss.

Expression of Hsap\ATX1^82Q.Scer\UAS in the wing pouch, driven by Scer\GAL4^C5, results in the production of smaller wings which have a thicker L3 vein, a missing posterior crossvein, and ectopic vein formation. These phenotypes are most prominent in the posterior part of the wing, where transgene expression is highest. Males showing high levels of Hsap\ATX1^82Q.Scer\UAS expression, when the transgene is inserted in the X chromosome, have atrophic wings.

(Lam et al., 2006)

Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^ninaE.PT results in neurodegeneration in the eye. At 2 days after eclosion, no obvious morphological changes in the photoreceptor cells are observed. At 28 days, many large holes and a loss of cell integrity is observed. On average, only one or two photoreceptor cells remain out of the eight found in normal eyes. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^GMR.PF induces eye abnormalities. The external structures of the eyes exhibit disorganised ommatidia and a loss of interommatidial bristles. They also exhibit a loss of rhabdomeres and tissue integrity. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^GMR.PF also generates extra wing-vein tissue. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^C5 in the wing pouch at 27^oC results in several vein abnormalities and wing atrophy. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^C96 in the wing margin causes bristle abnormalities including patterning defects and bristle loss. Overexpression of Hsap\ATX1^82Q.Scer\UAS in the sensory organ precursor cells under the control of Scer\GAL4^sca-109-68 causes a loss of thoracic bristles.

(Tsuda et al., 2005)

When Hsap\ATX1^82Q.Scer\UAS is driven by Scer\GAL4^GMR.PF at 23^oC, a mild degenerative phenotype is seen in the eye with a moderate disruption of the regular external lattice, a thinner retina layer, and mildly abnormal rhabdomeres.

(Chen et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by DNAlig1^GS20555, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by GS16203^GS16203, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by Xpd^GS36, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by CG8841^GS10988, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by mus81^GS1026, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by mms4^GS22070, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by mei-W68^GS10670, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by Blm^GS12928, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by DNAlig3^GS9746, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by fand^GS51333, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by grp^GS22185, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by RPA1^NIG.9633R, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by RecQ5^GS9658, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by grp^GS22185, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, enhanceable by Fen1^GS9817, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Hsap\NLK^UAS.cJa, Scer\GAL4^GMR.PU

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has increased cell death phenotype, enhanceable by Hsap\NLK^UAS.cJa, Scer\GAL4^GMR.PU

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by mub⁰⁴⁰⁹³/mub[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG14438[+]/sov^KG00226

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Hsap\RBM17^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Spf45^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by cic[+]/cic^D49

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5 has visible phenotype, enhanceable by cic[+]/cic^D49

(Lam et al., 2006)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PS has visible | adult stage phenotype, non-enhanceable by Ero1L^HMC05709, Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Hsap\NLK^KN.UAS.cJa, Scer\GAL4^GMR.PU

(Ju et al., 2013)

Suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has increased cell death | adult stage phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by grp^NIG.17161R, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by RPA1^GS10684, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, suppressible | partially by RPA1^GS10684, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible | partially by RPA1^GS10684, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, suppressible | partially by RecQ5^GS9658, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, suppressible | partially by grp^GS22185, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by PNKP^GS21535, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by spn-B^GS13042, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by CG12728^GS20801, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by CycH^GS9043, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by PolE1^GS9667, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by PolH^GS15067, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, suppressible by per^GS20805, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by nmo^adk2/nmo[+]

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has abnormal eye color phenotype, suppressible by nmo^adk2/nmo[+]

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by JIL-1^KG08229

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Raf^KK100982, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Raf^KK100982, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, suppressible | partially by Fnta^KK100303, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by Fnta^KK100303, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by lic^KK108550, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Sdr^KK104654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Aduk^KK102129, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Wnk^KK102654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by BubR1^DN.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by JIL-1^KK101300, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by JIL-1^KG08229

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Fntb^KK108342, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by drk^KG03077, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Ras64B^GD1517, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Raf^KK100982, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has short lived phenotype, suppressible | partially by JIL-1^KK101300, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by ppk^JF03250, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^elav-C155 has lethal | embryonic stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Akt1[+]/Akt⁰⁴²²⁶

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by vib^EP651, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sov^EP1438, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by mub^EP3623, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by vib^EP651, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Spf45^J23/Spf45[+]

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PU has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by Atx2^X1

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PU has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PU has short lived phenotype, suppressible | partially by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Atx2^X1

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by cic^UAS.cLa, Scer\GAL4^GMR.PF

(Lam et al., 2006)

NOT suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PS has visible | adult stage phenotype, non-suppressible by Ero1L^HMC05709, Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Fen1^GS9817, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Xpc^GS13949, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Xpc^GS13949, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Ercc1^GS20656, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Ercc1^GS20656, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by DNAlig1^GS20555, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Ssl1^GS20889, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Ssl1^GS20889, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by mrn^GS8019, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by mrn^GS8019, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Mms19^GS20566, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by GS16203^GS16203, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by fand^GS51333, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Xpd^GS36, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by CG8841^GS10988, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by rad50^GS7243, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by rad50^GS7243, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by spn-B^GS13042, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Gen^GS21003, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Gen^GS21003, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by tefu^GS20121, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by tefu^GS20121, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Irbp^GS10368, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Irbp^GS10368, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by mus81^GS1026, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by CG12728^GS20801, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by mms4^GS22070, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Tdp1^GS50611, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Tdp1^GS50611, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Pms2^GS10168, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by tou^GS16324, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Pms2^GS10168, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Msh6^GS13002, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Msh6^GS13002, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by PCNA^GS15324, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by PCNA^GS15324, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by mei-W68^GS10670, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by CycH^GS9043, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by PolD1^GS20870, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by PolD1^GS20870, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by PolE1^GS9667, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by tou^GS16324, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by PolH^GS15067, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by SMC6^GS21013, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by SMC6^GS21013, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Ubc6^GS22499, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by Ubc6^GS22499, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by per^GS20805, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by CG5181^GS11373, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by CG5181^GS11373, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by Blm^GS12928, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by tou^GS18086, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has short lived phenotype, non-suppressible by tou^GS18086, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by DNAlig3^GS9746, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^RapGAP1-OK6 has partially lethal phenotype, non-suppressible by PNKP^GS21535, Scer\GAL4^RapGAP1-OK6

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Nach^JF02566, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Enhancer of

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\TARDBP^GMR.PJ, Scer\GAL4^GMR.PU

(Tazelaar et al., 2020)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Tazelaar et al., 2020)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Other

Statement

Reference

14-3-3ε^UAS.cCa, Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has lethal phenotype

(Chen et al., 2003)

14-3-3ε^UAS.cCa, Hsap\ATXN1^82Q.UAS has lethal phenotype

(Chen et al., 2003)

Akt^UAS.Tag:HA, Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has melanotic necrosis phenotype

(Chen et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, enhanceable by Nmnat^UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by grp^GS22185, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by RPA1^NIG.9633R, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\NLK^UAS.cJa, Scer\GAL4^GMR.PU

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Hsc70-3^K97S.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by eff⁸

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Sin3A^dQ4

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by skd^L7062/skd[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by cpo^EP3378, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by 14-3-3ε^UAS.cCa, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by RhoGAPp190^EP1357, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by lncRNA:Hsrω^neo55/Hsromega[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Sc2[+]/Tecr⁰⁵⁶³⁴

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by CtBP[+]/CtBP⁰³⁴⁶³

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by GstS1[+]/GstS1⁰⁶²⁵³

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by mub⁰⁴⁰⁹³/mub[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by mub⁰⁴⁰⁹³/mub[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by mub⁰⁴⁰⁹³/mub[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Diap1⁴/th[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶/Rpd3[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG14438[+]/sov^KG00226

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by CG14438[+]/sov^KG00226

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has interommatidial bristle phenotype, enhanceable by CG14438[+]/sov^KG00226

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by CG14438[+]/sov^KG00226

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\RBM17^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Hsap\RBM17^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has interommatidial bristle phenotype, enhanceable by Hsap\RBM17^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Spf45^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Spf45^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has interommatidial bristle phenotype, enhanceable by Spf45^UAS.cLa, Scer\GAL4^GMR.PF

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has interommatidial bristle | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye photoreceptor cell | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^sca-109-68 has macrochaeta | adult stage phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^sca-109-68

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by cic[+]/cic^D49

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5 has wing vein L3 phenotype, enhanceable by cic[+]/cic^D49

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5 has wing vein | ectopic phenotype, enhanceable by cic[+]/cic^D49

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by 14-3-3ε^UAS.cCa, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by 14-3-3ε^UAS.cCa, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by 14-3-3ε^UAS.cCa, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dp(3;Y)L58

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Dp(3;Y)L58

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Dp(3;Y)L58

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Akt^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Sirt1^EP2300, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sirt1^EP2300, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by UbcE2H^EP1303, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by UbcE2H^EP1303, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS has eye phenotype, enhanceable by P{lacW}Jarid2^j2B8/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS has retina phenotype, enhanceable by P{lacW}Jarid2^j2B8/Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Ythdc1^EP3725, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Ythdc1^EP3725, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by cpo^EP3378, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by cpo^EP3378, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff⁵¹⁷⁸², Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff^EP674, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff^EP674, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by HDAC1^EP3672, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by HDAC1^EP3672, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CtBP⁰³⁴⁶³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CtBP⁰³⁴⁶³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CtBP^87De-10

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CtBP^87De-10

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by GstS1⁰⁶²⁵³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by GstS1⁰⁶²⁵³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by GstS1^k09303

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by GstS1^k09303

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by lncRNA:Hsrω^neo55

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by lncRNA:Hsrω^neo55

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Prosβ6^unspecified

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Prosβ6^unspecified

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Tecr⁰⁵⁶³⁴

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Tecr⁰⁵⁶³⁴

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Sin3A⁰⁸²⁶⁹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sin3A⁰⁸²⁶⁹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff⁸

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff⁸

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^pap-53

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^pap-53

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^pap-1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^pap-1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^L7062

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^L7062

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff⁵¹⁷⁸²

(Fernandez-Funez et al., 2000)

NOT Enhanced by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PS has eye phenotype, non-enhanceable by Ero1L^HMC05709, Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, non-enhanceable by Nmnat^cyt.UAS.PC, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Hsap\NLK^KN.UAS.cJa, Scer\GAL4^GMR.PU

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Pdk1^EP3553, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-enhanceable by Pdk1^EP3553, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS has retina phenotype, non-enhanceable by Pdk1^EP3553/Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by cpo^l1

(Fernandez-Funez et al., 2000)

Suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS has adult brain phenotype, suppressible | partially by Nmnat^UAS.PD, Scer\GAL4^nrv2.PS

(Ruan et al., 2015)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by grp^NIG.17161R, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by RPA1^GS10684, Scer\GAL4^GMR.PU

(Barclay et al., 2014)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by TER94^GS10258, Scer\GAL4^GMR.PU

(Fujita et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by nmo^adk2/nmo[+]

(Ju et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by lic^KK108550, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by lic^KK108550, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Sdr^KK104654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Sdr^KK104654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Aduk^KK102129, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Aduk^KK102129, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Wnk^KK102654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Wnk^KK102654, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by BubR1^DN.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by BubR1^DN.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by JIL-1^KG08229

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by JIL-1^KG08229

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Dsor1^G79

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by rl¹

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Fntb^KK108342, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Fntb^KK108342, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by drk^KG03077, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by drk^KG03077, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Sos^KG10074

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Ras85D⁰⁶⁶⁷⁷

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Ras64B^GD1517, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Ras64B^GD1517, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Raf^KK100982, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has photoreceptor phenotype, suppressible by Raf^KK100982, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by ppk^JF03250, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Sirt1^EP2300, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by pum^bem/pum[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by 14-3-3ε^ex4/14-3-3epsilon[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by 14-3-3ε^j2B10/14-3-3epsilon[+]

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Diap1^{UAS.cHa.Tag:MYC}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by ps[+]/ps³

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by ps[+]/ps^j449

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Nup44A^EP2417, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Akt1[+]/Akt⁰⁴²²⁶

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by Akt1[+]/Akt⁰⁴²²⁶

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Akt1[+]/Akt⁰⁴²²⁶

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by vib^EP651, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by vib^EP651, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by vib^EP651, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by vib^EP513, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sov^EP1438, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by sov^EP1438, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina phenotype, suppressible by sov^EP1438, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Spf45^J23/Spf45[+]

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by Spf45^J23/Spf45[+]

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible by Spf45^J23/Spf45[+]

(Lim et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere of eye photoreceptor cell phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere of eye photoreceptor cell phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Atx2^X1/Atx2[+], Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Atx2^X1/Atx2[+], Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, suppressible by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Atx2^X1/Atx2[+], Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has interommatidial bristle | adult stage phenotype, suppressible by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Atx2^X1/Atx2[+], Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina | adult stage phenotype, suppressible by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Atx2^X1/Atx2[+], Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye photoreceptor cell | adult stage phenotype, suppressible by Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^sca-109-68 has macrochaeta | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has interommatidial bristle | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has retina | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye photoreceptor cell | adult stage phenotype, suppressible by Atx2^X1/Atx2[+]

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by cic^UAS.cLa, Scer\GAL4^GMR.PF

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible by cic^UAS.cLa, Scer\GAL4^GMR.PF

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5 has posterior crossvein phenotype, suppressible by cic^UAS.cLa

(Lam et al., 2006)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Akt⁰⁴²²⁶

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Akt⁰⁴²²⁶

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by Akt⁰⁴²²⁶

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by GstE1^EP2231, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nup44A^EP2417, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by GstE1^EP2231, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Nup44A^EP2417, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT suppressed by

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PS has eye phenotype, non-suppressible by Ero1L^HMC05709, Scer\GAL4^GMR.PS

(Yeewa et al., 2024)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Nach^JF02566, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Pdk1^EP3553, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Pdk1^EP3553, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-suppressible by Pdk1^EP3553, Scer\GAL4^GMR.PF

(Chen et al., 2003)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Enhancer of

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\TARDBP^GMR.PJ, Scer\GAL4^GMR.PU

(Tazelaar et al., 2020)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Tazelaar et al., 2020)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of eye | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of ommatidium | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of interommatidial bristle | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of retina | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU is an enhancer of eye photoreceptor cell | adult stage phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PU

(Al-Ramahi et al., 2007)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Akt^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Chen et al., 2003)

NOT Enhancer of

Statement

Reference

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of cpo^l1

(Fernandez-Funez et al., 2000)

Suppressor of

Statement

Reference

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF is a suppressor of photoreceptor phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5 is a suppressor of posterior crossvein phenotype of Scer\GAL4^cv-c-C5, cic^UAS.cLa

(Lam et al., 2006)

NOT Suppressor of

Statement

Reference

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of mub⁰⁴⁰⁹³

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of cpo^l1

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of Sirt1^05327a

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of cpo¹

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Hsap\ATXN1^82Q.UAS/Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of pum⁶⁸⁰

(Fernandez-Funez et al., 2000)

Other

Statement

Reference

Akt^UAS.Tag:HA, Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype

(Chen et al., 2003)

GstE1^EP2231, Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype

(Fernandez-Funez et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of sens^Scer\UAS.cNa with Hsap\ATX1^82Q.Scer\UAS (both under the control of Scer\GAL4^sca-109-68) abolishes the loss of thoracic bristles phenotype of Hsap\ATX1^82Q.Scer\UAS overexpression, although the number of extra bristles is decreased compared to sens^Scer\UAS.cNa expression alone.

(Tsuda et al., 2005)

Xenogenetic Interactions

Statement

Reference

Co-expression of Nmnat^Scer\UAS.PD partially suppresses the age-dependent decline in climbing performance and signs of increased apoptosis in the brain in flies with expression of Hsap\ATXN1^82Q.Scer\UAS driven by Scer\GAL4^nrv2.PS; co-expression of Nmnat^{cyt.Scer\UAS.PC} has no effect, while co-expression of Nmnat^Scer\UAS.PC enhances the decline and apoptosis.

(Ruan et al., 2015)

Expression of RpA-70^GS10684 suppresses the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of RecQ5^GS9658 suppresses the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of grp^GS22185 suppresses the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of tou^GS16324 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of tou^GS18086 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of lig3^GS9746 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of CG9601^GS21535 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of Fen1^GS9817 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of mus210^GS13949 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Ercc1^GS20656 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of DNA-ligI^GS20555 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of Ssl1^GS20889 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of mrn^GS8019 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Mms19^GS20566 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method).

Expression of GS16203^GS16203 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of CG6197^GS51333 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of Xpd^GS36 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of CG8841^GS10988 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of rad50^GS7243 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of spn-B^GS13042 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of Gen^GS21003 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of tefu^GS20121 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Irbp^GS10368 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of mus81^GS1026 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of CG12728^GS20801 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of mms4^GS22070 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of gkt^GS50611 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Pms2^GS10168 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Msh6^GS13002 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of PCNA^GS15324 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of mei-W68^GS10670 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of CycH^GS9043 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of DNApol-δ^GS20870 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of DNApol-ε^GS9667 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of DNApol-η^GS15067 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of jnj^GS21013 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of per^GS20805 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is suppressed.

Expression of CG5181^GS11373 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of UbcD6^GS22499 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is not suppressed.

Expression of Blm^GS12928 does not suppress the reduction in eclosion rate seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^RapGAP1-OK6 (calculated using the Virtual Eclosion Rate (VER) method). The shortened lifespan is enhanced.

Expression of grp^GS22185 exacerbates the eye degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of grp^NIG.17161R suppresses the eye degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of RpA-70^GS10684 suppresses the eye degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of RpA-70^NIG.9633R enhances the eye degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Barclay et al., 2014)

Coexpression of TER94^GS10258 partially rescues the reduced retina thickness seen in animals expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PU results in reduced retina thickness compared to controls.

(Fujita et al., 2013)

One copy of nmo^adk2 strongly suppresses the retinal depigmentation and ommatidial disorganisation phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed in the eye under the control of Scer\GAL4^GMR.PU.

Co-expression of Hsap\NLK^Scer\UAS.cJa enhances the ommatidial disorganisation and retinal degeneration phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed in the eye under the control of Scer\GAL4^GMR.PU. There is a dramatic increase in the number and size of the areas of necrotic cell death.

Co-expression of Hsap\NLK^{KN.Scer\UAS.cJa} has little effect on the ommatidial disorganisation and retinal degeneration phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed in the eye under the control of Scer\GAL4^GMR.PU.

(Ju et al., 2013)

lic^KK108550 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Sdr^KK104654 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of CG8866^KK102129 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Wnk^KK102654 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of BubR1^DN.Scer\UAS partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of JIL-1^KK101300 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS is also partially rescued.

JIL-1^KG08229 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS is also partially rescued.

Dsor1^G79 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

rl¹ partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

Expression of CG17565^KK108342 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of drk^KG03077 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Sos^KG10074 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

Ras85D⁰⁶⁶⁷⁷ partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

Expression of Ras64B^GD1517 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of phl^KK100982 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

Expression of CG2976^KK100303 partially suppresses the progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS.

(Park et al., 2013)

One copy of GIIIspla2^EP1516 does not suppress the rough eye phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Qurashi et al., 2012)

Co-expression of two copies of P{Sym-UAS-Hsrω} restores pigmentation and reduces the roughening of Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF eyes.

Co-expression of a single copy of P{Sym-UAS-Hsrω} significantly lowers the proportion of Scer\GAL4^elav-C155, Hsap\ATX1^82Q.Scer\UAS flies dying at each stage of development, such that a greater fraction die as differentiated pharates.

(Mallik and Lakhotia, 2009)

Expression of DnaJ-1^EP411 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-3^{K97S.Scer\UAS} enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

eff⁸ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\STUB1^Scer\UAS.cAa suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Sin3A^dQ4 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of skd^L7062 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Sir2^EP2300 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of tara^EP3463 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of cpo^EP3378 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of pum^EP3461 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of pum^bem suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of 14-3-3ε^Scer\UAS.cCa enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of 14-3-3ε^ex4 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of 14-3-3ε^j2B10 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of RhoGAPp190^EP1357 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of th^{Scer\UAS.T:Hsap\MYC.cHa} suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of th⁴ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Hsrω^neo55 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Sc2⁰⁵⁶³⁴ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Rpd3⁰⁴⁵⁵⁶ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CtBP⁰³⁴⁶³ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of ps³ suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of ps^j449 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GstS1⁰⁶²⁵³ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Nup44A^EP2417 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Akt1^{Scer\UAS.T:Ivir\HA1} enhances the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Akt1⁰⁴²²⁶ suppresses the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of mub^EP3623 suppresses the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of mub⁰⁴⁰⁹³ enhances the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of vib^EP651 suppresses the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of vib^EP513 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG14438^EP1438 suppresses the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG14438^KG00226 enhances the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Pi3K92E^{Scer\UAS.T:Hsap\MYC} enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of mub^EP3623 partially suppresses the climbing defects seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS.

Expression of vib^EP651 partially suppresses the climbing defects seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS.

Expression of CG14438^EP1438 increases the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

One copy of CG14438^KG00226 reduces the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

Expression of vib^EP651 reduces the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

Expression of vib^EP513 reduces the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

Expression of Hsap\STUB1^Scer\UAS.cAa reduces the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

(Branco et al., 2008)

One copy of Spf45^J23 partially suppresses the ommatidial disorganisation and interommatidial bristle loss seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF at 30[o]C.

Expression of Hsap\RBM17^Scer\UAS.cLa enhances the ommatidial disorganisation and bristle loss seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF at 25[o]C.

Expression of Spf45^Scer\UAS.cLa enhances the ommatidial disorganisation and bristle loss seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF at 25[o]C.

(Lim et al., 2008)

The rough eye and rhabdomere phenotypes of Scer\GAL4^GMR.PF>Hsap\ATXN1^82Q.Scer\UAS are partially suppressed by co-expression of Nmnat^Scer\UAS.cZa.

The rough eye and rhabdomere phenotypes of Scer\GAL4^GMR.PF>Hsap\ATXN1^82Q.Scer\UAS are partially suppressed by co-expression of Nmnat^WR.Scer\UAS.

(Zhai et al., 2008)

The defective adult eye morphology (disorganization of ommatidia and loss of bristles, retinal tissue loss, photoreceptor cell defects) observed in flies expressing either Hsap\ATXN1^82Q.Scer\UAS or Atx2^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PU are exacerbated further when the two transgenes are co-expressed. The eye defects in Hsap\ATXN1^82Q.Scer\UAS expressing flies are partially suppressed by combination with a single copy of Atx2^X1. This suppression of the eye phenotype can be reverted (and the phenotype worsened again) by combination with Atx2^Scer\UAS.cSa.

The age-progressive locomotor impairment and shorter adult life span characteristic for flies expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^nrv2.PU as well as the loss of macrochaeta observed in flies expressing Hsap\ATXN1^82Q.Scer\UAS under the Scer\GAL4^sca-109-68 driver are significantly improved by combination with a Atx2^X1 in a heterozygous state.

The mild loss of macrochate observed in flies expressing Hsap\ATXN1^82Q.Scer\UAS under the control of Scer\GAL4^sca-109-68 is strongly exacerbated by co-expression of Atx2^Scer\UAS.cSa.

(Al-Ramahi et al., 2007)

Co-expression of Hsap\STUB1^Scer\UAS.cAa suppresses the eye phenotype caused by expression of Hsap\ATX1^82Q.Scer\UAS under the control of Scer\GAL4^GMR.PF, with the degree of suppression depending on the level of Hsap\STUB1^Scer\UAS.cAa expression.

(Al-Ramahi et al., 2006)

Coexpression of cic^Scer\UAS.cLa and Hsap\ATX1^82Q.Scer\UAS, both under the control of Scer\GAL4^GMR.PF, results in a milder eye phenotype than expression of Hsap\ATX1^82Q.Scer\UAS alone; there is less ommatidial disorganization and fusion and the interommatidial bristles are partially restored.

A cic^D49/+ background causes worsened ommatidial disorganization of Scer\GAL4^GMR.PF>Hsap\ATX1^82Q.Scer\UAS-expressing eyes, when flies are raised at room temperature.

Scer\GAL4^C5-driven expression of Hsap\ATX1^82Q.Scer\UAS in a cic^D49/+ background results in more prominent L3 vein thickening and increased ectopic wing vein formation in the posterior part of the interveins compared to expression of Hsap\ATX1^82Q.Scer\UAS in a wild-type background.

Coexpression of cic^Scer\UAS.cLa and Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^C5, results in restoration of the posterior crossvein, which is missing in flies expressing either transgene separately.

(Lam et al., 2006)

The addition of 14-3-3ε^Scer\UAS.cCa enhances the eye phenotypes seen in Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF animals alone. They have profoundly disordered ommatidia, a thin and disorganised retina layer, and grossly abnormal rhabdomeres. Animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} and Hsap\ATX1^82Q.Scer\UAS (under the control of Scer\GAL4^GMR.PF) have a much stronger eye phenotype than seen in either Akt1^{Scer\UAS.T:Ivir\HA1} or Hsap\ATX1^82Q.Scer\UAS on their own. Profoundly disorganised ommatidia and numerous necrotic spots are seen, as well a severely disorganised retina with missing or malformed rhabdomeres. The addition of Dp(3;Y)L58 to animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^GMR.PF) enhances the eye neurodegeneration phenotype. The addition of Pi3K92E^{Scer\UAS.T:Hsap\MYC} (driven by Scer\GAL4^GMR.PF) dramatically worsens the Hsap\ATX1^82Q.Scer\UAS neurodegeneration phenotype in the eye. the addition of Pk61C^EP3553 (driven by Scer\GAL4^GMR.PF) has no effect on the neurodegeneration phenotype in the eye. The addition of Akt1⁰⁴²²⁶ to animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^GMR.PF) suppresses the eye neurodegeneration phenotype.

(Chen et al., 2003)

Expression of Hsap\ATX1^30Q.Scer\UAS when driven by Scer\GAL4^GMR.PF can lead to a severe degeneration of the retina. When driven by Scer\GAL4^VNC.ap, a progressive elimination of the cell bodies and axonal projections of interneurons. The addition of DnaJ-1^EP411 to Hsap\ATX1^82Q.Scer\UAS flies produces a suppression of the eye phenotype, revealing less disrupted ommatidia and improved retinal thickness.

(Fernandez-Funez et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33818

w¹¹¹⁸; P{UAS-Hsap\ATX1.82Q}M6

39740

P{UAS-Hsap\ATX1.82Q}F7, y¹ w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\ATX1^82Q.Scer\UAS

Hsap\ATXN1^82Q.Scer\UAS

Hsap\ATXN1^82Q.UAS

Name Synonyms

Secondary FlyBase IDs

References (43)

Report Sections

Open Close