Allele Hsap\ATX1^82Q.Scer\UAS

General Information
Symbol	Hsap\ATX1^82Q.Scer\UAS	Species	H. sapiens
Name		FlyBase ID	FBal0119474
Feature type	allele	Created / Updated	2006-08-20/2006-08-20
Associated gene	Hsap\ATX1

Allele class
Mutagen	in vitro construct \| regulatory fusion
Nature of the Allele
Allele class
Mutagen	in vitro construct \| regulatory fusion (Fernandez-Funez et al., 2000)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A Hsap\ATX1 cDNA containing 82 CAG repeats is driven by Scer\UAS sequences. (Fernandez-Funez et al., 2000)
Assay mode	In transgenic Drosophila (allele of foreign species in genome of drosophilid) (Fernandez-Funez et al., 2000, Tsuda et al., 2005)
Carried in construct	P{UAS-Hsap\ATX1.82Q} (Tsuda et al., 2005, Fernandez-Funez et al., 2000, Chen et al., 2003, Al-Ramahi et al., 2006, Lam et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^C5 (Lam et al., 2006) visible, with Scer\GAL4^GMR.PF (Al-Ramahi et al., 2006, Lam et al., 2006)
Phenotype Manifest In
	interneuron, with Scer\GAL4^VNC.ap (Fernandez-Funez et al., 2000) interneuron & cell body, with Scer\GAL4^VNC.ap (Fernandez-Funez et al., 2000) interneuron & axon, with Scer\GAL4^VNC.ap (Fernandez-Funez et al., 2000) eye, with Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000, Chen et al., 2003) retina, with Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000, Chen et al., 2003, Al-Ramahi et al., 2006) wing vein \| ectopic, with Scer\GAL4^GMR.PF (Tsuda et al., 2005) interommatidial bristle, with Scer\GAL4^GMR.PF (Tsuda et al., 2005, Al-Ramahi et al., 2006, Lam et al., 2006) ommatidium, with Scer\GAL4^GMR.PF (Tsuda et al., 2005, Al-Ramahi et al., 2006, Lam et al., 2006) rhabdomere, with Scer\GAL4^GMR.PF (Chen et al., 2003) eye, with Scer\GAL4^ninaE.PT (Tsuda et al., 2005) eye photoreceptor cell, with Scer\GAL4^ninaE.PT (Tsuda et al., 2005) wing vein \| conditional - heat sensitive, with Scer\GAL4^C5 (Tsuda et al., 2005) wing, with Scer\GAL4^C5 (Tsuda et al., 2005, Lam et al., 2006) wing vein L3, with Scer\GAL4^C5 (Lam et al., 2006) posterior crossvein, with Scer\GAL4^C5 (Lam et al., 2006) wing vein \| ectopic, with Scer\GAL4^C5 (Lam et al., 2006) wing margin bristle, with Scer\GAL4^bbg-C96 (Tsuda et al., 2005) wing, with Scer\GAL4^bbg-C96 (Tsuda et al., 2005) metathoracic bristle, with Scer\GAL4^sca-109-68 (Tsuda et al., 2005) mesothoracic bristle, with Scer\GAL4^sca-109-68 (Tsuda et al., 2005)
Detailed Description
	Statement Reference When Hsap\ATX1^82Q.Scer\UAS is driven by Scer\GAL4^GMR.PF at 23^oC, a mild degenerative phenotype is seen in the eye with a moderate disruption of the regular external lattice, a thinner retina layer, and mildly abnormal rhabdomeres. (Chen et al., 2003) Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^ninaE.PT results in neurodegeneration in the eye. At 2 days after eclosion, no obvious morphological changes in the photoreceptor cells are observed. At 28 days, many large holes and a loss of cell integrity is observed. On average, only one or two photoreceptor cells remain out of the eight found in normal eyes. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^GMR.PF induces eye abnormalities. The external structures of the eyes exhibit disorganised ommatidia and a loss of interommatidial bristles. They also exhibit a loss of rhabdomeres and tissue integrity. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^GMR.PF also generates extra wing-vein tissue. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^C5 in the wing pouch at 27^oC results in several vein abnormalities and wing atrophy. Overexpression of Hsap\ATX1^82Q.Scer\UAS, under the control of Scer\GAL4^C96 in the wing margin causes bristle abnormalities including patterning defects and bristle loss. Overexpression of Hsap\ATX1^82Q.Scer\UAS in the sensory organ precursor cells under the control of Scer\GAL4^sca-109-68 causes a loss of thoracic bristles. (Tsuda et al., 2005) Flies expressing Hsap\ATX1[82Q.Scer\UAS] under the control of Scer\GAL4[GMR.PF] have a severe external eye phenotype with disorganised and fused ommatidia and loss of interommatidial bristles. There is severe retinal degeneration, as evident by reduction in depth of the retina. (Al-Ramahi et al., 2006) Expression of Hsap\ATX1[82Q.Scer\UAS] in the eye, under the control of Scer\GAL4[GMR.PF], causes ommatidial disorganization and fusion, as well as interommatidial bristle loss. Expression of Hsap\ATX1[82Q.Scer\UAS] in the wing pouch, driven by Scer\GAL4[C5], results in the production of smaller wings which have a thicker L3 vein, a missing posterior crossvein, and ectopic vein formation. These phenotypes are most prominent in the posterior part of the wing, where transgene expression is highest. Males showing high levels of Hsap\ATX1[82Q.Scer\UAS] expression, when the transgene is inserted in the X chromosome, have atrophic wings. (Lam et al., 2006)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by cic[+]/cic^D49 (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^C5 has visible phenotype, enhanceable by cic[+]/cic^D49 (Lam et al., 2006)
Suppressed by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by cic^Scer\UAS.cLa, Scer\GAL4^GMR.PF (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\STUB1^Scer\UAS.cAa, Scer\GAL4^GMR.PF (Al-Ramahi et al., 2006)
Other
Statement Reference Akt1^{Scer\UAS.T:Ivir\HA1}, Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has melanotic necrosis phenotype (Chen et al., 2003, Chen et al., 2003) 14-3-3ε^Scer\UAS.cCa, Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4[-] has lethal phenotype (Chen et al., 2003, Chen et al., 2003) 14-3-3ε^Scer\UAS.cCa, Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has lethal phenotype (Chen et al., 2003, Chen et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by 14-3-3ε^Scer\UAS.cCa, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by 14-3-3ε^Scer\UAS.cCa, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by 14-3-3ε^Scer\UAS.cCa, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Akt1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Akt1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Akt1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pi3K92E^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Pi3K92E^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Pi3K92E^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Rpd3^EP3672, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Rpd3^EP3672, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Sir2^EP2300, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sir2^EP2300, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Ubc-E2H^EP1303, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Ubc-E2H^EP1303, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by YT521-B^EP3725, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by YT521-B^EP3725, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by cpo^EP3378, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by cpo^EP3378, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff⁵¹⁷⁸², Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff^EP674, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff^EP674, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by pum^EP3461, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by tara^EP3463, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dp(3;Y)L58 (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Dp(3;Y)L58 (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, enhanceable by Dp(3;Y)L58 (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CtBP⁰³⁴⁶³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CtBP⁰³⁴⁶³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CtBP^87De-10 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CtBP^87De-10 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by GstS1⁰⁶²⁵³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by GstS1⁰⁶²⁵³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by GstS1^k09303 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by GstS1^k09303 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsrω⁰⁵²⁴¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsrω⁰⁵²⁴¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsrω^neo55 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsrω^neo55 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pros26^unspecified (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Pros26^unspecified (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Sc2⁰⁵⁶³⁴ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sc2⁰⁵⁶³⁴ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Sin3A⁰⁸²⁶⁹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Sin3A⁰⁸²⁶⁹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Uch-L3^j2B8 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Uch-L3^j2B8 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff⁸ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff⁸ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^pap-53 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^pap-53 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^pap-1 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^pap-1 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by skd^L7062 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by skd^L7062 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by eff⁵¹⁷⁸² (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by cic[+]/cic^D49 (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^C5 has wing vein L3 phenotype, enhanceable by cic[+]/cic^D49 (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^C5 has wing vein \| ectopic phenotype, enhanceable by cic[+]/cic^D49 (Lam et al., 2006)
NOT Enhanced by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Pk61C^EP3553, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-enhanceable by Pk61C^EP3553, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS has retina phenotype, non-enhanceable by Pk61C^EP3553/Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by pum¹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by pum¹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Sir2^05327a (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Sir2^05327a (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cpo¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by cpo¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by cpo^l1 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by cpo^l1 (Fernandez-Funez et al., 2000)
Suppressed by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by GstE1^EP2231, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by GstE1^EP2231, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by mub^EP3623, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nup44A^EP2417, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Nup44A^EP2417, Scer\GAL4^GMR.PF (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Akt1⁰⁴²²⁶ (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Akt1⁰⁴²²⁶ (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by Akt1⁰⁴²²⁶ (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible \| partially by cic^Scer\UAS.cLa, Scer\GAL4^GMR.PF (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has interommatidial bristle phenotype, suppressible \| partially by cic^Scer\UAS.cLa, Scer\GAL4^GMR.PF (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^C5 has posterior crossvein phenotype, suppressible by cic^Scer\UAS.cLa (Lam et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by Hsap\STUB1^Scer\UAS.cAa, Scer\GAL4^GMR.PF (Al-Ramahi et al., 2006) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\STUB1^Scer\UAS.cAa, Scer\GAL4^GMR.PF (Al-Ramahi et al., 2006)
NOT suppressed by
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Pk61C^EP3553, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Pk61C^EP3553, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-suppressible by Pk61C^EP3553, Scer\GAL4^GMR.PF (Chen et al., 2003) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by pum¹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by pum¹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sir2^05327a (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Sir2^05327a (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cpo¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by cpo¹ (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cpo^l1 (Fernandez-Funez et al., 2000) Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by cpo^l1 (Fernandez-Funez et al., 2000)
Enhancer of
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Akt1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Chen et al., 2003)
NOT Enhancer of
Statement Reference Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of eye phenotype of pum¹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of retina phenotype of pum¹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of retina phenotype of Sir2^05327a (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of eye phenotype of Sir2^05327a (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of eye phenotype of mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of retina phenotype of mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of eye phenotype of cpo¹ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of retina phenotype of cpo¹ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of eye phenotype of cpo^l1 (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-enhancer of retina phenotype of cpo^l1 (Fernandez-Funez et al., 2000)
Suppressor of
Statement Reference Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^C5 is a suppressor of posterior crossvein phenotype of Scer\GAL4^C5, cic^Scer\UAS.cLa (Lam et al., 2006)
NOT Suppressor of
Statement Reference Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of eye phenotype of pum¹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of retina phenotype of pum¹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of eye phenotype of Sir2^05327a (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of retina phenotype of Sir2^05327a (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of eye phenotype of mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of retina phenotype of mub⁰⁴⁰⁹³ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of eye phenotype of cpo¹ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of retina phenotype of cpo¹ (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of eye phenotype of cpo^l1 (Fernandez-Funez et al., 2000) Scer\GAL4^GMR.PF/Hsap\ATX1^82Q.Scer\UAS is a non-suppressor of retina phenotype of cpo^l1 (Fernandez-Funez et al., 2000)
Other
Statement Reference Akt1^{Scer\UAS.T:Ivir\HA1}, Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has ommatidium phenotype (Chen et al., 2003, Chen et al., 2003) GstE1^EP2231, Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF has ommatidium phenotype (Fernandez-Funez et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Coexpression of sens^Scer\UAS.cNa with Hsap\ATX1^82Q.Scer\UAS (both under the control of Scer\GAL4^sca-109-68) abolishes the loss of thoracic bristles phenotype of Hsap\ATX1^82Q.Scer\UAS overexpression, although the number of extra bristles is decreased compared to sens^Scer\UAS.cNa expression alone. (Tsuda et al., 2005)
Xenogenetic Interactions
Statement Reference Expression of Hsap\ATX1^30Q.Scer\UAS when driven by Scer\GAL4^GMR.PF can lead to a severe degeneration of the retina. When driven by Scer\GAL4^VNC.ap, a progressive elimination of the cell bodies and axonal projections of interneurons. The addition of DnaJ-1^EP411 to Hsap\ATX1^82Q.Scer\UAS flies produces a suppression of the eye phenotype, revealing less disrupted ommatidia and improved retinal thickness. (Fernandez-Funez et al., 2000) The addition of 14-3-3ε^Scer\UAS.cCa enhances the eye phenotypes seen in Hsap\ATX1^82Q.Scer\UAS, Scer\GAL4^GMR.PF animals alone. They have profoundly disordered ommatidia, a thin and disorganised retina layer, and grossly abnormal rhabdomeres. Animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} and Hsap\ATX1^82Q.Scer\UAS (under the control of Scer\GAL4^GMR.PF) have a much stronger eye phenotype than seen in either Akt1^{Scer\UAS.T:Ivir\HA1} or Hsap\ATX1^82Q.Scer\UAS on their own. Profoundly disorganised ommatidia and numerous necrotic spots are seen, as well a severely disorganised retina with missing or malformed rhabdomeres. The addition of Dp(3;Y)L58 to animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^GMR.PF) enhances the eye neurodegeneration phenotype. The addition of Pi3K92E^{Scer\UAS.T:Hsap\MYC} (driven by Scer\GAL4^GMR.PF) dramatically worsens the Hsap\ATX1^82Q.Scer\UAS neurodegeneration phenotype in the eye. the addition of Pk61C^EP3553 (driven by Scer\GAL4^GMR.PF) has no effect on the neurodegeneration phenotype in the eye. The addition of Akt1⁰⁴²²⁶ to animals expressing Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^GMR.PF) suppresses the eye neurodegeneration phenotype. (Chen et al., 2003) Co-expression of Hsap\STUB1[Scer\UAS.cAa] suppresses the eye phenotype caused by expression of Hsap\ATX1[82Q.Scer\UAS] under the control of Scer\GAL4[GMR.PF], with the degree of suppression depending on the level of Hsap\STUB1[Scer\UAS.cAa] expression. (Al-Ramahi et al., 2006) Coexpression of cic[Scer\UAS.cLa] and Hsap\ATX1[82Q.Scer\UAS], both under the control of Scer\GAL4[GMR.PF], results in a milder eye phenotype than expression of Hsap\ATX1[82Q.Scer\UAS] alone; there is less ommatidial disorganization and fusion and the interommatidial bristles are partially restored. A cic[D49]/+ background causes worsened ommatidial disorganization of Scer\GAL4[GMR.PF]>Hsap\ATX1[82Q.Scer\UAS]-expressing eyes, when flies are raised at room temperature. Scer\GAL4[C5]-driven expression of Hsap\ATX1[82Q.Scer\UAS] in a cic[D49]/+ background results in more prominent L3 vein thickening and increased ectopic wing vein formation in the posterior part of the interveins compared to expression of Hsap\ATX1[82Q.Scer\UAS] in a wild-type background. Coexpression of cic[Scer\UAS.cLa] and Hsap\ATX1[82Q.Scer\UAS], under the control of Scer\GAL4[C5], results in restoration of the posterior crossvein, which is missing in flies expressing either transgene separately. (Lam et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\ATX1^82Q.Scer\UAS
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Al-Ramahi et al., 2006, J. Biol. Chem. 281(36): 26714--26724 CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. [FBrf0192832] Lam et al., 2006, Cell 127(7): 1335--1347 ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. [FBrf0193611] Tsuda et al., 2005, Cell 122(4): 633--644 The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. [FBrf0187241] Chen et al., 2003, Cell 113(4): 457--468 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. [FBrf0159690] Fernandez-Funez et al., 2000, Nature 408(6808): 101--106 Identification of genes that modify ataxin-1-induced neurodegeneration. [FBrf0131287]

Allele Hsap\ATX182Q.Scer\UAS

Allele Hsap\ATX1^82Q.Scer\UAS