Larval ddaE neurons expressing Hsap\ATXN130Q.UAS under the control of Scer\GAL4221 do not show significant changes in growing microtubules within dendrites, as compared to neurons in controls.
Flies expressing high levels of Hsap\ATX130Q.Scer\UAS under the control of Scer\GAL4GMR.PF have a moderate external eye phenotype, with mild ommatidial disorganisation. These flies show a reduction in retinal depth.
Expression of Hsap\ATX130Q.Scer\UAS when driven by Scer\GAL4GMR.PF leads to degeneration of the retina. An increase in the temperature at which the flies are raised, or a doubling of the does, leads to a strengthening of the eye phenotype. Expression driven by Scer\GAL4VNC.ap leads to very mild neuronal loss.